ID   PRS7_XENLA              Reviewed;         433 AA.
AC   P46472; Q5D088;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=26S proteasome regulatory subunit 7;
DE   AltName: Full=26S proteasome AAA-ATPase subunit RPT1;
DE   AltName: Full=Proteasome 26S subunit ATPase 2;
DE   AltName: Full=xMSS1 {ECO:0000303|PubMed:7711076};
GN   Name=psmc2; Synonyms=mss1 {ECO:0000303|PubMed:7711076};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RX   PubMed=7711076; DOI=10.1016/0167-4781(95)00022-9;
RA   Nacken W.K.F., Kingsman A., Kingsman S., Sablitzky F., Sorg C.;
RT   "A homologue of the human MSS1 gene, a positive modulator of HIV-1 gene
RT   expression, is massively expressed in Xenopus oocytes.";
RL   Biochim. Biophys. Acta 1261:293-295(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The 26S proteasome is involved in the ATP-dependent
CC       degradation of ubiquitinated proteins. The regulatory (or ATPase)
CC       complex confers ATP dependency and substrate specificity to the 26S
CC       complex (By similarity). {ECO:0000250|UniProtKB:P35998}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P35998}. Nucleus
CC       {ECO:0000250|UniProtKB:P35998}.
CC   -!- SIMILARITY: Belongs to the AAA ATPase family. {ECO:0000305}.
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DR   EMBL; X80157; CAA56438.1; -; mRNA.
DR   EMBL; BC054143; AAH54143.1; -; mRNA.
DR   PIR; S53709; S53709.
DR   RefSeq; NP_001084136.1; NM_001090667.1.
DR   AlphaFoldDB; P46472; -.
DR   SMR; P46472; -.
DR   BioGRID; 100652; 2.
DR   DNASU; 399327; -.
DR   GeneID; 399327; -.
DR   KEGG; xla:399327; -.
DR   CTD; 399327; -.
DR   Xenbase; XB-GENE-1000023; psmc2.L.
DR   OMA; INGYKKF; -.
DR   OrthoDB; 571919at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 399327; Expressed in muscle tissue and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0022624; C:proteasome accessory complex; ISS:UniProtKB.
DR   GO; GO:0000502; C:proteasome complex; ISS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0036402; F:proteasome-activating activity; ISS:UniProtKB.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
DR   Gene3D; 2.40.50.140; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR005937; 26S_Psome_P45-like.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041569; AAA_lid_3.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR035245; PSMC2.
DR   PANTHER; PTHR23073:SF13; PTHR23073:SF13; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF17862; AAA_lid_3; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01242; 26Sp45; 1.
DR   PROSITE; PS00674; AAA; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cytoplasm; Nucleotide-binding; Nucleus; Proteasome;
KW   Reference proteome.
FT   CHAIN           1..433
FT                   /note="26S proteasome regulatory subunit 7"
FT                   /id="PRO_0000084712"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         216..223
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   433 AA;  48664 MW;  F272881521C1B2B4 CRC64;
     MPDYLGADQR KTKEEEKEDK PIRSLDEGDI ALLKTYGQST YSRQIKQVED DIQQLLKKIN
     ELTGIKESDT GLAPPALWDL AADKQTLQSE QPLQVARCTK IINADSEDPK YIINVKQFAK
     FVVDLSDQVA PTDIEEGMRV GVDRNKYQIH IPLPPKIDPT VTMMQVEEKP DVTYSDVGGC
     KEQIEKLREV VETPLLHPER FVNLGIEPPK GVLLFGPPGT GKTLCARAVA NRTDACFIRV
     IGSELVQKYV GEGARMVREL FEMARTKKAC LIFFDEIDAI GGARFDDGAG GDNEVQRTML
     ELINQLDGFD PRGNIKVLMA TNRPDTLDPA LMRPGRLDRK IEFSLPDLEG RTHIFKIHAR
     SMSVERDIRF ELLARLCPNS TGAEIRSVCT EAGMFAIRAR RKVATEKDFL EAVNKVIKSY
     AKFSATPRYM TYN