PRSA1_BACAN
ID PRSA1_BACAN Reviewed; 287 AA.
AC Q81U45; Q6I2D3; Q6KW60;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 118.
DE RecName: Full=Foldase protein PrsA 1;
DE EC=5.2.1.8;
DE Flags: Precursor;
GN Name=prsA1; Synonyms=prsA-1; OrderedLocusNames=BA_1041, GBAA_1041, BAS0974;
OS Bacillus anthracis.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=1392;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames / isolate Porton;
RX PubMed=12721629; DOI=10.1038/nature01586;
RA Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T.,
RA Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R.,
RA Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M.,
RA Kolonay J.F., Beanan M.J., Dodson R.J., Brinkac L.M., Gwinn M.L.,
RA DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C.,
RA Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y.,
RA Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M.,
RA Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E.,
RA White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M.,
RA Hanna P.C., Kolstoe A.-B., Fraser C.M.;
RT "The genome sequence of Bacillus anthracis Ames and comparison to closely
RT related bacteria.";
RL Nature 423:81-86(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames ancestor;
RX PubMed=18952800; DOI=10.1128/jb.01347-08;
RA Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D.,
RA Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.;
RT "The complete genome sequence of Bacillus anthracis Ames 'Ancestor'.";
RL J. Bacteriol. 191:445-446(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sterne;
RA Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K.,
RA Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R.,
RA Richardson P., Rubin E., Tice H.;
RT "Complete genome sequence of Bacillus anthracis Sterne.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP CHARACTERIZATION.
RX PubMed=12606539; DOI=10.1074/jbc.m301244200;
RA Williams R.C., Rees M.L., Jacobs M.F., Pragai Z., Thwaite J.E.,
RA Baillie L.W., Emmerson P.T., Harwood C.R.;
RT "Production of Bacillus anthracis protective antigen is dependent on the
RT extracellular chaperone, PrsA.";
RL J. Biol. Chem. 278:18056-18062(2003).
CC -!- FUNCTION: Plays a major role in protein secretion by helping the post-
CC translocational extracellular folding of several secreted proteins.
CC Important for the secretion of the protective antigen. The three PsrA
CC proteins in this organism show different but overlapping substrate
CC specificities.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC ChEBI:CHEBI:83834; EC=5.2.1.8;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PrsA family. {ECO:0000305}.
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DR EMBL; AE016879; AAP25027.1; -; Genomic_DNA.
DR EMBL; AE017334; AAT30143.1; -; Genomic_DNA.
DR EMBL; AE017225; AAT53298.1; -; Genomic_DNA.
DR RefSeq; NP_843541.1; NC_003997.3.
DR RefSeq; WP_000710050.1; NZ_WXXJ01000044.1.
DR RefSeq; YP_027247.1; NC_005945.1.
DR PDB; 6XD8; X-ray; 1.52 A; A/B=129-221.
DR PDBsum; 6XD8; -.
DR AlphaFoldDB; Q81U45; -.
DR SMR; Q81U45; -.
DR STRING; 261594.GBAA_1041; -.
DR PRIDE; Q81U45; -.
DR DNASU; 1088973; -.
DR EnsemblBacteria; AAP25027; AAP25027; BA_1041.
DR EnsemblBacteria; AAT30143; AAT30143; GBAA_1041.
DR GeneID; 45021076; -.
DR KEGG; ban:BA_1041; -.
DR KEGG; bar:GBAA_1041; -.
DR KEGG; bat:BAS0974; -.
DR PATRIC; fig|198094.11.peg.1030; -.
DR eggNOG; COG0760; Bacteria.
DR HOGENOM; CLU_034646_6_1_9; -.
DR OMA; TMKGSTI; -.
DR Proteomes; UP000000427; Chromosome.
DR Proteomes; UP000000594; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006457; P:protein folding; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:InterPro.
DR Gene3D; 1.10.3120.10; -; 1.
DR Gene3D; 3.10.50.40; -; 1.
DR HAMAP; MF_01145; Foldase_PrsA; 1.
DR InterPro; IPR023059; Foldase_PrsA.
DR InterPro; IPR046357; PPIase_dom_sf.
DR InterPro; IPR000297; PPIase_PpiC.
DR InterPro; IPR023058; PPIase_PpiC_CS.
DR InterPro; IPR037041; Trigger_fac_C_sf.
DR InterPro; IPR027304; Trigger_fact/SurA_dom_sf.
DR SUPFAM; SSF109998; SSF109998; 1.
DR PROSITE; PS01096; PPIC_PPIASE_1; 1.
DR PROSITE; PS50198; PPIC_PPIASE_2; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Isomerase; Lipoprotein; Membrane; Palmitate;
KW Reference proteome; Rotamase; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..287
FT /note="Foldase protein PrsA 1"
FT /id="PRO_0000029291"
FT DOMAIN 130..220
FT /note="PpiC"
FT LIPID 19
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT LIPID 19
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255"
FT STRAND 133..142
FT /evidence="ECO:0007829|PDB:6XD8"
FT HELIX 143..152
FT /evidence="ECO:0007829|PDB:6XD8"
FT TURN 153..156
FT /evidence="ECO:0007829|PDB:6XD8"
FT HELIX 159..166
FT /evidence="ECO:0007829|PDB:6XD8"
FT HELIX 170..173
FT /evidence="ECO:0007829|PDB:6XD8"
FT TURN 174..177
FT /evidence="ECO:0007829|PDB:6XD8"
FT STRAND 178..182
FT /evidence="ECO:0007829|PDB:6XD8"
FT HELIX 189..195
FT /evidence="ECO:0007829|PDB:6XD8"
FT STRAND 207..209
FT /evidence="ECO:0007829|PDB:6XD8"
FT STRAND 212..221
FT /evidence="ECO:0007829|PDB:6XD8"
SQ SEQUENCE 287 AA; 32456 MW; 2A62D3358FC53685 CRC64;
MKKAMLALAA TSVIALSACG TSSSDKIVTS KAGDITKDEF YEQMKTQAGK QVLNNMVMEK
VLIKNYKVED KEVDKKYDEM KKQYGDQFDT LLKQQGIKEE TLKTGVRAQL AQEKAIEKTI
TDKELKDNYK PEIKASHILV KDEATAKKVK EELGQGKSFE ELAKQYSEDT GSKEKGGDLG
FFGAGKMVKE FEDAAYKLKK DEVSEPVKSQ FGYHIIKVTD IKEPEKSFEQ SKADIKKELV
AKKSQDGEFM NDLMMKEIKK ADVKVDDKDL KDLFEEKKAD AKKEEKK
