PRSD_RHIME
ID PRSD_RHIME Reviewed; 582 AA.
AC Q7ANN4; O33678;
DT 25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT 25-JAN-2012, sequence version 2.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Type I secretion system ATP-binding protein PrsD;
GN Name=prsD; OrderedLocusNames=RB1292; ORFNames=SM_b21466;
OS Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS meliloti).
OG Plasmid pSymB (megaplasmid 2).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX NCBI_TaxID=266834;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBUNIT.
RC STRAIN=1021;
RX PubMed=11902715; DOI=10.1046/j.1365-2958.1997.4481804.x;
RA York G.M., Walker G.C.;
RT "The Rhizobium meliloti exoK gene and prsD/prsE/exsH genes encode
RT components of independent degradative pathways which contribute to
RT production of low-molecular-weight succinoglycan.";
RL Mol. Microbiol. 25:117-134(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11481431; DOI=10.1073/pnas.161294698;
RA Finan T.M., Weidner S., Wong K., Buhrmester J., Chain P., Vorhoelter F.J.,
RA Hernandez-Lucas I., Becker A., Cowie A., Gouzy J., Golding B., Puehler A.;
RT "The complete sequence of the 1,683-kb pSymB megaplasmid from the N2-fixing
RT endosymbiont Sinorhizobium meliloti.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:9889-9894(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11474104; DOI=10.1126/science.1060966;
RA Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA Wong K., Yeh K.-C., Batut J.;
RT "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL Science 293:668-672(2001).
CC -!- FUNCTION: Mediates secretion of glycanase ExsH.
CC {ECO:0000269|PubMed:11902715}.
CC -!- SUBUNIT: Part of a type I secretion system composed of PrsD and PrsE.
CC {ECO:0000305|PubMed:11902715}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAC49692.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; U89163; AAB64091.1; -; Genomic_DNA.
DR EMBL; AL591985; CAC49692.2; ALT_INIT; Genomic_DNA.
DR PIR; D96003; D96003.
DR RefSeq; NP_437832.2; NC_003078.1.
DR RefSeq; WP_027991853.1; NC_003078.1.
DR AlphaFoldDB; Q7ANN4; -.
DR SMR; Q7ANN4; -.
DR STRING; 266834.SM_b21466; -.
DR EnsemblBacteria; CAC49692; CAC49692; SM_b21466.
DR GeneID; 61601215; -.
DR KEGG; sme:SM_b21466; -.
DR PATRIC; fig|266834.11.peg.6215; -.
DR eggNOG; COG4618; Bacteria.
DR HOGENOM; CLU_000604_95_6_5; -.
DR Proteomes; UP000001976; Plasmid pSymB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030256; C:type I protein secretion system complex; IEA:InterPro.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0030253; P:protein secretion by the type I secretion system; IEA:InterPro.
DR Gene3D; 1.20.1560.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR010128; ATPase_T1SS_PrtD-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24222:SF0; PTHR24222:SF0; 1.
DR Pfam; PF00664; ABC_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF90123; SSF90123; 1.
DR TIGRFAMs; TIGR01842; type_I_sec_PrtD; 1.
DR PROSITE; PS50929; ABC_TM1F; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW Nucleotide-binding; Plasmid; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..582
FT /note="Type I secretion system ATP-binding protein PrsD"
FT /id="PRO_0000415267"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 22..301
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 332..568
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 366..373
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 582 AA; 62120 MW; 102FEF388C9ED6BA CRC64;
MATSKGRNAD PAAALRDCRA AFIGVGVASA LVNLLYLTGS FFMLEVYDRI LPSRSIPSLI
ALSLLALLLY AFQGAFELIR GRMLVRIAGA LDESLNGRIY RAIVKAPLKL RMQGDGLQAL
RDFDQVRSFL SGVGPAALFD LPWLPFYIAI CFLFHPVIGL IAIIGGLILT LLTYLTNRGT
QAPAKKASEA GGLRNVFAQA SQRNAEVVHA MGMSARLTAL WERRNTEFRD ENRRTSDIGN
GYGALSKVFR MALQSGVLAA GAVLVIRGEA SPGIIIAGSI LTARALAPVE LAIGNWRGLV
AARQSWQRLK ELLNALPEAD APLQLPDPHE RLTVEGLASG PPAAQRLVVS DVNFTVRAGG
AVGVIGPSAS GKSSLARAIL GIWPAYRGSV RLDGAALDQW DSDALGKHVG YLPQDVELFA
GTIAQNICRF AEDATSEAIV AAAKAARVND LILRLPNGYD TEIGDGGMTL SAGQRQRVAL
ARALYGDPFL VVLDEPNSNL DAEGEQALSE AIMSVRSRGG IVIVVAHRPS ALASVDLVLM
MNEGRMQAFG PKEQVLGQVL RPQQVERQNA LKVVAEGQEA KQ
