PRSR1_HUMAN
ID PRSR1_HUMAN Reviewed; 944 AA.
AC Q86XN7; A6NJ97; Q6P2S2; Q7Z3X5; Q8N3D2; Q8N3P1; Q9H9M1;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Proline and serine-rich protein 1;
GN Name=PROSER1; Synonyms=C13orf23, KIAA2032;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RA Nagase T., Kikuno R., Ohara O.;
RT "The nucleotide sequence of a long cDNA clone isolated from human.";
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Amygdala, Colon endothelium, and Melanoma;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ALA-571.
RC TISSUE=Brain, and PNS;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 165-944 (ISOFORMS 1/2), AND
RP VARIANT ALA-571.
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [8]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q86XN7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86XN7-2; Sequence=VSP_055641;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB14204.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC67659.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB107354; BAC67659.1; ALT_INIT; mRNA.
DR EMBL; AL833854; CAD38713.1; -; mRNA.
DR EMBL; AL834435; CAD39095.1; -; mRNA.
DR EMBL; BX647471; CAH56138.1; -; mRNA.
DR EMBL; AL445590; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471075; EAX08610.1; -; Genomic_DNA.
DR EMBL; BC053566; AAH53566.1; -; mRNA.
DR EMBL; BC064348; AAH64348.1; -; mRNA.
DR EMBL; AK022723; BAB14204.1; ALT_INIT; mRNA.
DR CCDS; CCDS9368.2; -. [Q86XN7-1]
DR RefSeq; NP_079414.3; NM_025138.4. [Q86XN7-1]
DR RefSeq; XP_005266602.1; XM_005266545.3.
DR AlphaFoldDB; Q86XN7; -.
DR BioGRID; 123178; 21.
DR CORUM; Q86XN7; -.
DR IntAct; Q86XN7; 16.
DR STRING; 9606.ENSP00000332034; -.
DR GlyGen; Q86XN7; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q86XN7; -.
DR PhosphoSitePlus; Q86XN7; -.
DR BioMuta; PROSER1; -.
DR DMDM; 125950653; -.
DR EPD; Q86XN7; -.
DR jPOST; Q86XN7; -.
DR MassIVE; Q86XN7; -.
DR MaxQB; Q86XN7; -.
DR PaxDb; Q86XN7; -.
DR PeptideAtlas; Q86XN7; -.
DR PRIDE; Q86XN7; -.
DR ProteomicsDB; 1319; -.
DR ProteomicsDB; 70304; -. [Q86XN7-1]
DR ABCD; Q86XN7; 1 sequenced antibody.
DR Antibodypedia; 67457; 62 antibodies from 16 providers.
DR DNASU; 80209; -.
DR Ensembl; ENST00000352251.8; ENSP00000332034.4; ENSG00000120685.20. [Q86XN7-1]
DR Ensembl; ENST00000625998.2; ENSP00000486159.1; ENSG00000120685.20. [Q86XN7-2]
DR GeneID; 80209; -.
DR KEGG; hsa:80209; -.
DR MANE-Select; ENST00000352251.8; ENSP00000332034.4; NM_025138.5; NP_079414.3.
DR UCSC; uc001uwy.5; human. [Q86XN7-1]
DR CTD; 80209; -.
DR DisGeNET; 80209; -.
DR GeneCards; PROSER1; -.
DR HGNC; HGNC:20291; PROSER1.
DR HPA; ENSG00000120685; Low tissue specificity.
DR neXtProt; NX_Q86XN7; -.
DR OpenTargets; ENSG00000120685; -.
DR PharmGKB; PA134912550; -.
DR VEuPathDB; HostDB:ENSG00000120685; -.
DR eggNOG; ENOG502QSVH; Eukaryota.
DR GeneTree; ENSGT00730000111188; -.
DR HOGENOM; CLU_018622_0_0_1; -.
DR InParanoid; Q86XN7; -.
DR OMA; YNSTHKV; -.
DR OrthoDB; 395841at2759; -.
DR PhylomeDB; Q86XN7; -.
DR TreeFam; TF331494; -.
DR PathwayCommons; Q86XN7; -.
DR SignaLink; Q86XN7; -.
DR BioGRID-ORCS; 80209; 8 hits in 1077 CRISPR screens.
DR ChiTaRS; PROSER1; human.
DR GenomeRNAi; 80209; -.
DR Pharos; Q86XN7; Tdark.
DR PRO; PR:Q86XN7; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; Q86XN7; protein.
DR Bgee; ENSG00000120685; Expressed in secondary oocyte and 172 other tissues.
DR ExpressionAtlas; Q86XN7; baseline and differential.
DR Genevisible; Q86XN7; HS.
DR InterPro; IPR028011; DUF4476.
DR InterPro; IPR042616; PROSER1.
DR PANTHER; PTHR14880; PTHR14880; 1.
DR Pfam; PF14771; DUF4476; 2.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Reference proteome.
FT CHAIN 1..944
FT /note="Proline and serine-rich protein 1"
FT /id="PRO_0000274309"
FT REGION 233..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 608..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 912..944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 928..944
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:22814378"
FT VAR_SEQ 16..37
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_055641"
FT VARIANT 571
FT /note="V -> A (in dbSNP:rs3751379)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_030253"
FT VARIANT 847
FT /note="S -> T (in dbSNP:rs17058955)"
FT /id="VAR_030254"
FT CONFLICT 541
FT /note="L -> P (in Ref. 6; BAB14204)"
FT /evidence="ECO:0000305"
FT CONFLICT 666
FT /note="L -> S (in Ref. 6; BAB14204)"
FT /evidence="ECO:0000305"
FT CONFLICT 786
FT /note="P -> L (in Ref. 6; BAB14204)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 944 AA; 95698 MW; DC236EA48D320C2F CRC64;
MDKKSFEMVL DEIRKAVLTE YKLKAIEYVH GYFSSEQVVD LLRYFSWAEP QLKAMKALQH
KMVAVQPTEV VNILNCFTFS KDKLVALELL ASNIIDAQNS RPIEDLFRVN MSEKKRCKRI
LEQAFKGGCK APHAMISSCG TIPGNPYPKG RPSRINGIFP GTPLKKDGEE CTNEGKGIAA
RILGPSKPPP STYNPHKPVP YPIPPCRPHA TIAPSAYNNA GLVPLANVIA PPPPPYTPNP
VGTENEDLSN PSKPIQNQTF STPASQLFSP HGSNPSTPAA TPVPTASPVK AINHPSASAA
ATVSGMNLLN TVLPVFPGQV SSAVHTPQPS IPNPTVIRTP SLPTAPVTSI HSTTTTPVPS
IFSGLVSLPG PSATPTAATP TPGPTPRSTL GSSEAFASTS APFTSLPFST SSSAASTSNP
NSASLSSVFA GLPLPLPPTS QGLSNPTPVI AGGSTPSVAG PLGVNSPLLS ALKGFLTSND
TNLINSSALS SAVTSGLASL SSLTLQNSDS SASAPNKCYA PSAIPTPQRT STPGLALFPG
LPSPVANSTS TPLTLPVQSP LATAASASTS VPVSCGSSAS LLRGPHPGTS DLHISSTPAA
TTLPVMIKTE PTSPTPSAFK GPSHSGNPSH GTLGLSGTLG RAYTSTSVPI SLSACLNPAL
SGLSSLSTPL NGSNPLSSIS LPPHGSSTPI APVFTALPSF TSLTNNFPLT GNPSLNPSVS
LPGSLIATSS TAATSTSLPH PSSTAAVLSG LSASAPVSAA PFPLNLSTAV PSLFSVTQGP
LSSSNPSYPG FSVSNTPSVT PALPSFPGLQ APSTVAAVTP LPVAATAPSP APVLPGFASA
FSSNFNSALV AQAGLSSGLQ AAGSSVFPGL LSLPGIPGFP QNPSQSSLQE LQHNAAAQSA
LLQQVHSASA LESYPAQPDG FPSYPSAPGT PFSLQPSLSQ SGWQ
