PRSR1_MOUSE
ID PRSR1_MOUSE Reviewed; 913 AA.
AC Q5PRE5; Q3UGD1; Q6PFH9; Q80WX5; Q8BYT2;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Proline and serine-rich protein 1;
GN Name=Proser1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hypothalamus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye, Fetal brain, and Head;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC29986.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK038404; BAC29986.1; ALT_INIT; mRNA.
DR EMBL; AK147998; BAE28278.1; -; mRNA.
DR EMBL; BC051453; AAH51453.1; -; mRNA.
DR EMBL; BC057544; AAH57544.1; -; mRNA.
DR EMBL; BC086674; AAH86674.1; -; mRNA.
DR CCDS; CCDS17346.1; -.
DR RefSeq; NP_775558.2; NM_173382.1.
DR AlphaFoldDB; Q5PRE5; -.
DR BioGRID; 229294; 2.
DR IntAct; Q5PRE5; 2.
DR STRING; 10090.ENSMUSP00000055253; -.
DR iPTMnet; Q5PRE5; -.
DR PhosphoSitePlus; Q5PRE5; -.
DR EPD; Q5PRE5; -.
DR jPOST; Q5PRE5; -.
DR MaxQB; Q5PRE5; -.
DR PaxDb; Q5PRE5; -.
DR PeptideAtlas; Q5PRE5; -.
DR PRIDE; Q5PRE5; -.
DR ProteomicsDB; 291755; -.
DR ABCD; Q5PRE5; 1 sequenced antibody.
DR Antibodypedia; 67457; 62 antibodies from 16 providers.
DR DNASU; 212127; -.
DR Ensembl; ENSMUST00000058577; ENSMUSP00000055253; ENSMUSG00000049504.
DR GeneID; 212127; -.
DR KEGG; mmu:212127; -.
DR UCSC; uc008pev.1; mouse.
DR CTD; 80209; -.
DR MGI; MGI:1919933; Proser1.
DR VEuPathDB; HostDB:ENSMUSG00000049504; -.
DR eggNOG; ENOG502QSVH; Eukaryota.
DR GeneTree; ENSGT00730000111188; -.
DR HOGENOM; CLU_018622_0_0_1; -.
DR InParanoid; Q5PRE5; -.
DR OMA; YNSTHKV; -.
DR OrthoDB; 395841at2759; -.
DR PhylomeDB; Q5PRE5; -.
DR TreeFam; TF331494; -.
DR BioGRID-ORCS; 212127; 1 hit in 57 CRISPR screens.
DR ChiTaRS; Proser1; mouse.
DR PRO; PR:Q5PRE5; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q5PRE5; protein.
DR Bgee; ENSMUSG00000049504; Expressed in ear vesicle and 223 other tissues.
DR Genevisible; Q5PRE5; MM.
DR InterPro; IPR028011; DUF4476.
DR InterPro; IPR042616; PROSER1.
DR PANTHER; PTHR14880; PTHR14880; 1.
DR Pfam; PF14771; DUF4476; 2.
PE 1: Evidence at protein level;
KW Acetylation; Reference proteome.
FT CHAIN 1..913
FT /note="Proline and serine-rich protein 1"
FT /id="PRO_0000274310"
FT REGION 233..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 592..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 888..913
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 892..913
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q86XN7"
SQ SEQUENCE 913 AA; 91978 MW; 86F0D0210DCF6DAC CRC64;
MDKKSFETVL DEIRKAVLTE YKLKAIEYVH GYFSSEQVVD LLRYFSWAEP QLKAMKALQH
KMVAVHPAEV VSILSCFTFS KDKLAALELL ASNIVDAQNS RPIEDLFRIN MSEKKRCKRV
LEQASKAGCK APHAMISSCG TFPGNPYPKG KPSRINGIFP GTPLKKDGEE ITNEGKGIAA
RILGPSKPPP STYNPHKPVP YPIPPCRPHA TIAPSAYNNA GLVPLANVIA PGVPPPPPYT
PNPAGTDNED LSSQSKPTQS QTFSTPASQL FSPHGSSNPS TPAATPVPAV SPAKAVNHPS
VSAAATGAGM SATNTALAVF PTPQPNTPNP TVIRTPSVPA TPVTSTHSTT PTPVPSVFSG
LVPLPGLSAT PTLPTQASSI SRVTLASSET FASTCAPFSG HSSASSTAGS ASNPITAPLS
SVFAGLPLPF PPASHSIATP TPSVIASAAG PHGVNSPLLS ALKGFLTSND THLINSSALP
SAVTSGLASL SSLPNRNSDS PASATNKCYP PAAVPAAQRS STPGLAMFPG LQSPVASATS
VAPTLPAQSP LATPSTAVPV SCGSSGSLLH GPHAGGISSA PAAATMPVMI KSEPTSPPPS
AFKGPAHPGT PVRGTLGLSG ALGRGYPTTS VPISVSTCLN PALSGLSSLS TPLAGSMSLP
PHASSTPIAP VFTALPPFTS LTNSFPLPGS PSLNPAVSLA GSSTTTTSAA VHPSSATVRS
VLPTSNASPA AFPLNLSTAV PSLFAVTQGP LPTSNPSYPG FPVSSAPSGA PTLPSFPGLQ
APSTVAVTPL PVAASAPSPA PVLPGFASAF SSNFNSALVA QAGLSSGLQA AGSSVFPGLL
SLPGIPGFSQ APPQSSLQEL QHSAAAQSAL LQQVHSASAL ESYPAQADGF PSYPSTPGTP
FSLQTGLSQS GWQ
