PRSR2_HUMAN
ID PRSR2_HUMAN Reviewed; 435 AA.
AC Q86WR7; D3DRR8; Q5W0J9; Q5W0K0; Q5W0K1; Q5W0K2; Q6PJC8; Q8N317;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2005, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Proline and serine-rich protein 2;
GN Name=PROSER2; Synonyms=C10orf47;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP VAL-412.
RC TISSUE=Blood, and Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROTEIN SEQUENCE OF 41-52; 174-186; 190-218; 250-268; 319-330; 338-364;
RP 381-387; 398-414 AND 428-435, PHOSPHORYLATION AT SER-43; SER-179 AND
RP SER-212, METHYLATION AT ARG-252 AND ARG-320, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC TISSUE=Ovarian carcinoma;
RA Bienvenut W.V., Dozynkiewicz M., Norman J.C.;
RL Submitted (JAN-2010) to UniProtKB.
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Platelet;
RX PubMed=18088087; DOI=10.1021/pr0704130;
RA Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,
RA Schuetz C., Walter U., Gambaryan S., Sickmann A.;
RT "Phosphoproteome of resting human platelets.";
RL J. Proteome Res. 7:526-534(2008).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43; THR-146; THR-167 AND
RP SER-212, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43 AND SER-212, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43; SER-179; SER-212 AND
RP SER-215, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-8; SER-43; THR-45; SER-179;
RP SER-212; SER-215; SER-312 AND SER-400, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166 AND SER-179, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [12]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-252; ARG-320; ARG-378 AND
RP ARG-414, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Colon carcinoma;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- INTERACTION:
CC Q86WR7; Q9NUX5: POT1; NbExp=2; IntAct=EBI-2880603, EBI-752420;
CC Q86WR7-2; O95833: CLIC3; NbExp=5; IntAct=EBI-13089670, EBI-10192241;
CC Q86WR7-2; Q92993: KAT5; NbExp=3; IntAct=EBI-13089670, EBI-399080;
CC Q86WR7-2; Q9BUL8: PDCD10; NbExp=3; IntAct=EBI-13089670, EBI-740195;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q86WR7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86WR7-2; Sequence=VSP_014955;
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DR EMBL; AL138898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471072; EAW86336.1; -; Genomic_DNA.
DR EMBL; CH471072; EAW86339.1; -; Genomic_DNA.
DR EMBL; BC017269; AAH17269.1; -; mRNA.
DR EMBL; BC029134; AAH29134.2; -; mRNA.
DR EMBL; BC048800; AAH48800.1; -; mRNA.
DR CCDS; CCDS7085.1; -. [Q86WR7-1]
DR RefSeq; NP_694988.3; NM_153256.3. [Q86WR7-1]
DR RefSeq; XP_011517740.1; XM_011519438.2. [Q86WR7-1]
DR RefSeq; XP_016871517.1; XM_017016028.1. [Q86WR7-1]
DR AlphaFoldDB; Q86WR7; -.
DR SMR; Q86WR7; -.
DR BioGRID; 129035; 53.
DR IntAct; Q86WR7; 37.
DR STRING; 9606.ENSP00000277570; -.
DR GlyGen; Q86WR7; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q86WR7; -.
DR PhosphoSitePlus; Q86WR7; -.
DR BioMuta; PROSER2; -.
DR DMDM; 73620073; -.
DR EPD; Q86WR7; -.
DR jPOST; Q86WR7; -.
DR MassIVE; Q86WR7; -.
DR MaxQB; Q86WR7; -.
DR PaxDb; Q86WR7; -.
DR PeptideAtlas; Q86WR7; -.
DR PRIDE; Q86WR7; -.
DR ProteomicsDB; 70193; -. [Q86WR7-1]
DR ProteomicsDB; 70194; -. [Q86WR7-2]
DR Antibodypedia; 52497; 54 antibodies from 12 providers.
DR DNASU; 254427; -.
DR Ensembl; ENST00000277570.10; ENSP00000277570.5; ENSG00000148426.13. [Q86WR7-1]
DR Ensembl; ENST00000622831.4; ENSP00000484913.1; ENSG00000148426.13. [Q86WR7-2]
DR GeneID; 254427; -.
DR KEGG; hsa:254427; -.
DR MANE-Select; ENST00000277570.10; ENSP00000277570.5; NM_153256.4; NP_694988.3.
DR UCSC; uc001ikx.3; human. [Q86WR7-1]
DR CTD; 254427; -.
DR DisGeNET; 254427; -.
DR GeneCards; PROSER2; -.
DR HGNC; HGNC:23728; PROSER2.
DR HPA; ENSG00000148426; Tissue enhanced (liver).
DR neXtProt; NX_Q86WR7; -.
DR OpenTargets; ENSG00000148426; -.
DR PharmGKB; PA134910296; -.
DR VEuPathDB; HostDB:ENSG00000148426; -.
DR eggNOG; ENOG502QWQ9; Eukaryota.
DR GeneTree; ENSGT00940000154315; -.
DR HOGENOM; CLU_050385_0_0_1; -.
DR InParanoid; Q86WR7; -.
DR OMA; YEHRQPD; -.
DR OrthoDB; 1060512at2759; -.
DR PhylomeDB; Q86WR7; -.
DR TreeFam; TF335482; -.
DR PathwayCommons; Q86WR7; -.
DR SignaLink; Q86WR7; -.
DR BioGRID-ORCS; 254427; 14 hits in 1082 CRISPR screens.
DR ChiTaRS; PROSER2; human.
DR GenomeRNAi; 254427; -.
DR Pharos; Q86WR7; Tdark.
DR PRO; PR:Q86WR7; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q86WR7; protein.
DR Bgee; ENSG00000148426; Expressed in pancreatic ductal cell and 141 other tissues.
DR ExpressionAtlas; Q86WR7; baseline and differential.
DR Genevisible; Q86WR7; HS.
PE 1: Evidence at protein level;
KW Alternative splicing; Direct protein sequencing; Methylation;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..435
FT /note="Proline and serine-rich protein 2"
FT /id="PRO_0000089792"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 92..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..175
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 8
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 43
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|Ref.4, ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 45
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 146
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 166
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 167
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 179
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|Ref.4, ECO:0007744|PubMed:18088087,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163,
FT ECO:0007744|PubMed:24275569"
FT MOD_RES 212
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|Ref.4, ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 215
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 252
FT /note="Asymmetric dimethylarginine; alternate"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 252
FT /note="Omega-N-methylarginine; alternate"
FT /evidence="ECO:0000269|Ref.4"
FT MOD_RES 312
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 320
FT /note="Dimethylated arginine; alternate"
FT /evidence="ECO:0000269|Ref.4"
FT MOD_RES 320
FT /note="Omega-N-methylarginine; alternate"
FT /evidence="ECO:0000269|Ref.4, ECO:0007744|PubMed:24129315"
FT MOD_RES 378
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 400
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 414
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT VAR_SEQ 245..338
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_014955"
FT VARIANT 412
FT /note="A -> V (in dbSNP:rs12253554)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_023097"
FT CONFLICT 323
FT /note="P -> R (in Ref. 3; AAH48800)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 435 AA; 45802 MW; 223F949909100AA1 CRC64;
MPVTHRKSDA SDMNSDTSPS CRLRAFSRGG SLESRSSSSR SRSFTLDDES LKYLTHEEKD
VLLFFEETID SLDEDFEEPV LCDGGVCCLC SPSLEESTSS PSEPEDVIDL VQPAPGAGEA
EGLPEGTQAA GPAPAGKEHR KQDAETPPPP DPPAPETLLA PPPLPSTPDP PRRELRAPSP
PVEHPRLLRS VPTPLVMAQK ISERMAGNEA LSPTSPFREG RPGEWRTPAA RGPRSGDPGP
GPSHPAQPKA PRFPSNIIVT NGAAREPRRT LSRAAVSVQE RRAQVLATIH GHAGAFPAAG
DAGEGAPGGG SSPERVARGR GLPGPAESLR AGGQAPRGPA LANGFPSAHE ALKSAPSSFA
PAGKSLCFRP GPALPSTRAR QSFPGPRQPN GAQDWRRADS LPRPQGITVQ FAGRGSSEEA
RREALRKLGL LRESS
