PRSR2_MOUSE
ID PRSR2_MOUSE Reviewed; 471 AA.
AC Q8C5R2; Q3V1L9; Q8R017; Q8R2Z9;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Proline and serine-rich protein 2;
GN Name=Proser2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II, and FVB/N; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-220 AND SER-223, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH26904.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK077380; BAC36776.1; -; mRNA.
DR EMBL; AK132370; BAE21131.1; -; mRNA.
DR EMBL; AL928735; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466542; EDL07978.1; -; Genomic_DNA.
DR EMBL; BC023193; AAH23193.1; -; mRNA.
DR EMBL; BC025867; AAH25867.1; -; mRNA.
DR EMBL; BC026904; AAH26904.1; ALT_INIT; mRNA.
DR CCDS; CCDS15671.1; -.
DR RefSeq; NP_001153129.1; NM_001159657.1.
DR RefSeq; NP_659132.2; NM_144883.4.
DR RefSeq; XP_011237278.1; XM_011238976.2.
DR AlphaFoldDB; Q8C5R2; -.
DR SMR; Q8C5R2; -.
DR STRING; 10090.ENSMUSP00000060780; -.
DR iPTMnet; Q8C5R2; -.
DR PhosphoSitePlus; Q8C5R2; -.
DR MaxQB; Q8C5R2; -.
DR PaxDb; Q8C5R2; -.
DR PRIDE; Q8C5R2; -.
DR ProteomicsDB; 291535; -.
DR Antibodypedia; 52497; 54 antibodies from 12 providers.
DR Ensembl; ENSMUST00000054254; ENSMUSP00000060780; ENSMUSG00000045319.
DR Ensembl; ENSMUST00000114942; ENSMUSP00000110592; ENSMUSG00000045319.
DR GeneID; 227545; -.
DR KEGG; mmu:227545; -.
DR UCSC; uc008ige.2; mouse.
DR CTD; 254427; -.
DR MGI; MGI:2442238; Proser2.
DR VEuPathDB; HostDB:ENSMUSG00000045319; -.
DR eggNOG; ENOG502QWQ9; Eukaryota.
DR GeneTree; ENSGT00940000154315; -.
DR HOGENOM; CLU_050385_0_0_1; -.
DR InParanoid; Q8C5R2; -.
DR OMA; YEHRQPD; -.
DR OrthoDB; 1060512at2759; -.
DR TreeFam; TF335482; -.
DR BioGRID-ORCS; 227545; 1 hit in 70 CRISPR screens.
DR ChiTaRS; Proser2; mouse.
DR PRO; PR:Q8C5R2; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8C5R2; protein.
DR Bgee; ENSMUSG00000045319; Expressed in epithelium of lens and 171 other tissues.
DR ExpressionAtlas; Q8C5R2; baseline and differential.
DR Genevisible; Q8C5R2; MM.
PE 1: Evidence at protein level;
KW Methylation; Phosphoprotein; Reference proteome.
FT CHAIN 1..471
FT /note="Proline and serine-rich protein 2"
FT /id="PRO_0000089793"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 310..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 383..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..183
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 43
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86WR7"
FT MOD_RES 45
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q86WR7"
FT MOD_RES 187
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86WR7"
FT MOD_RES 220
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 223
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 263
FT /note="Asymmetric dimethylarginine; alternate"
FT /evidence="ECO:0000250|UniProtKB:Q86WR7"
FT MOD_RES 263
FT /note="Omega-N-methylarginine; alternate"
FT /evidence="ECO:0000250|UniProtKB:Q86WR7"
FT MOD_RES 431
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86WR7"
FT MOD_RES 450
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q86WR7"
FT CONFLICT 222
FT /note="T -> I (in Ref. 4; AAH23193/AAH25867)"
FT /evidence="ECO:0000305"
FT CONFLICT 249
FT /note="V -> M (in Ref. 2; AAH26904)"
FT /evidence="ECO:0000305"
FT CONFLICT 347
FT /note="C -> R (in Ref. 2; AAH26904)"
FT /evidence="ECO:0000305"
FT CONFLICT 443
FT /note="I -> N (in Ref. 2; AAH26904)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 471 AA; 50421 MW; 01EB8C7414789AD6 CRC64;
MPGNQQKPES LETDSDTSPS CGLSDLSRGG SLESRCSSSR SRSFTMDDES LKHLTHEEKD
VILFFEETLD SLEYDFDEPA LCDSGIHCHS PQSLEESPSS HSEPEDVIDL VQPAPASGEA
ESLPDMPQVT GAPSDTKHGT PFLEGGKQAA ENSLPPPDSR GPEVFPLPPS LPVPAPSAPR
KELMSPSPPA EHPKLLRSVP TPLVIAQKIS EKLAGNEALS PTSPSKEGRP GEWRTPTSPA
SRNGDHVGVW HRHTTQSAPK VHRFPSNISV TNSAGKDFNK TISKAAVNVQ ERKAQVLANI
NGMSFIAAGD TSSEERWQKA EEQRSGSADG ARTLGRAGMA GEPGAPCAGV PARAQQSRAV
QTEQPPALAN GFQSVHEALR SEPSSFVPTS KTITFRPDPA VTGKLARQNA SRSLYEPRPD
GSQDARKRTG SLPRAVGFRP QGITVQFSGR GSTEEARREA LRKLGLLKEN L
