PRSR3_HUMAN
ID PRSR3_HUMAN Reviewed; 480 AA.
AC Q2NL68; Q8NDI3; Q8WWC8; Q96NL4;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-FEB-2006, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Proline and serine-rich protein 3;
GN Name=PROSER3; Synonyms=C19orf55;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
RC TISSUE=Prostate, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q2NL68; Q8IYE0: CCDC146; NbExp=3; IntAct=EBI-11336487, EBI-10749669;
CC Q2NL68; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-11336487, EBI-10961624;
CC Q2NL68; Q8TD31-3: CCHCR1; NbExp=5; IntAct=EBI-11336487, EBI-10175300;
CC Q2NL68; Q9UJX2: CDC23; NbExp=3; IntAct=EBI-11336487, EBI-396137;
CC Q2NL68; Q4KMZ1: IQCC; NbExp=3; IntAct=EBI-11336487, EBI-12206419;
CC Q2NL68; Q9Y5B8: NME7; NbExp=5; IntAct=EBI-11336487, EBI-744782;
CC Q2NL68; Q96ES7: SGF29; NbExp=3; IntAct=EBI-11336487, EBI-743117;
CC Q2NL68; Q96N95-3: ZNF396; NbExp=5; IntAct=EBI-11336487, EBI-12328453;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q2NL68-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q2NL68-2; Sequence=VSP_027698, VSP_027701, VSP_027702,
CC VSP_027703;
CC Name=3;
CC IsoId=Q2NL68-3; Sequence=VSP_027698, VSP_027699, VSP_027700;
CC Name=4;
CC IsoId=Q2NL68-4; Sequence=VSP_027699, VSP_027700;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH17947.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK055219; BAB70878.1; -; mRNA.
DR EMBL; AL833894; CAD38750.2; -; mRNA.
DR EMBL; AC002398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC017947; AAH17947.1; ALT_INIT; mRNA.
DR EMBL; BC110893; AAI10894.1; -; mRNA.
DR CCDS; CCDS46056.2; -. [Q2NL68-1]
DR RefSeq; NP_001034976.2; NM_001039887.2. [Q2NL68-1]
DR RefSeq; XP_011524838.1; XM_011526536.2. [Q2NL68-2]
DR AlphaFoldDB; Q2NL68; -.
DR BioGRID; 127121; 17.
DR IntAct; Q2NL68; 12.
DR STRING; 9606.ENSP00000380116; -.
DR GlyGen; Q2NL68; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q2NL68; -.
DR PhosphoSitePlus; Q2NL68; -.
DR BioMuta; PROSER3; -.
DR DMDM; 121941602; -.
DR EPD; Q2NL68; -.
DR jPOST; Q2NL68; -.
DR MassIVE; Q2NL68; -.
DR MaxQB; Q2NL68; -.
DR PaxDb; Q2NL68; -.
DR PeptideAtlas; Q2NL68; -.
DR PRIDE; Q2NL68; -.
DR ProteomicsDB; 61420; -. [Q2NL68-1]
DR ProteomicsDB; 61421; -. [Q2NL68-2]
DR ProteomicsDB; 61422; -. [Q2NL68-3]
DR ProteomicsDB; 61423; -. [Q2NL68-4]
DR Antibodypedia; 44565; 40 antibodies from 12 providers.
DR DNASU; 148137; -.
DR Ensembl; ENST00000396908.8; ENSP00000380116.5; ENSG00000167595.15. [Q2NL68-1]
DR Ensembl; ENST00000536950.5; ENSP00000466822.1; ENSG00000167595.15. [Q2NL68-3]
DR Ensembl; ENST00000537459.5; ENSP00000439886.2; ENSG00000167595.15. [Q2NL68-4]
DR Ensembl; ENST00000620918.4; ENSP00000482508.1; ENSG00000167595.15. [Q2NL68-2]
DR GeneID; 148137; -.
DR KEGG; hsa:148137; -.
DR UCSC; uc002obo.2; human. [Q2NL68-1]
DR CTD; 148137; -.
DR DisGeNET; 148137; -.
DR GeneCards; PROSER3; -.
DR HGNC; HGNC:25204; PROSER3.
DR HPA; ENSG00000167595; Low tissue specificity.
DR neXtProt; NX_Q2NL68; -.
DR OpenTargets; ENSG00000167595; -.
DR PharmGKB; PA162378639; -.
DR VEuPathDB; HostDB:ENSG00000167595; -.
DR eggNOG; ENOG502S6GS; Eukaryota.
DR GeneTree; ENSGT00390000001986; -.
DR HOGENOM; CLU_022718_0_0_1; -.
DR InParanoid; Q2NL68; -.
DR OMA; SPPGFFW; -.
DR OrthoDB; 1610316at2759; -.
DR PhylomeDB; Q2NL68; -.
DR PathwayCommons; Q2NL68; -.
DR SignaLink; Q2NL68; -.
DR BioGRID-ORCS; 148137; 4 hits in 226 CRISPR screens.
DR GenomeRNAi; 148137; -.
DR Pharos; Q2NL68; Tdark.
DR PRO; PR:Q2NL68; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q2NL68; protein.
DR Bgee; ENSG00000167595; Expressed in buccal mucosa cell and 103 other tissues.
DR ExpressionAtlas; Q2NL68; baseline and differential.
DR Genevisible; Q2NL68; HS.
DR InterPro; IPR037646; PROSER3.
DR PANTHER; PTHR22045; PTHR22045; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..480
FT /note="Proline and serine-rich protein 3"
FT /id="PRO_0000299482"
FT REGION 1..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 111..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 336..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 419..451
FT /evidence="ECO:0000255"
FT COMPBIAS 24..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..276
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..301
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..480
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 408
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7TSA6"
FT VAR_SEQ 145
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_027698"
FT VAR_SEQ 182..194
FT /note="NLHTWNSSLLDLE -> VTSPFTPSLGCLN (in isoform 3 and
FT isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_027699"
FT VAR_SEQ 195..480
FT /note="Missing (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_027700"
FT VAR_SEQ 210..220
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027701"
FT VAR_SEQ 320..336
FT /note="AESLKAKALPPAAGSVI -> VSRGREEPGGSWRRGWV (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027702"
FT VAR_SEQ 337..480
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027703"
FT VARIANT 302
FT /note="S -> R (in dbSNP:rs231219)"
FT /id="VAR_056845"
FT VARIANT 365
FT /note="K -> N (in dbSNP:rs231217)"
FT /id="VAR_061631"
FT CONFLICT Q2NL68-2:209
FT /note="P -> S (in Ref. 1; BAB70878)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 480 AA; 51075 MW; 68BF6EA452455363 CRC64;
MDRSLPVFSI QDSPFGDAPL GRSHYWPSQS QTWCPKTLSP SRSQRSRLPQ APKALATGPN
SPELFEESWP SSSGTPSLPS TTEGQMWASP APTLIDSGDS VVAKYINRFR QAQPTSREER
QPAGPTPADF WWLQSDSPDP SSQSAAAGAN KPEGRPHTAV PTAVNVTSAS HAVAPLQEIK
QNLHTWNSSL LDLETLSLQS RAARLLKRSK ASISSSSSLS PSDASTSSFP TSSDGLSPFS
ETFIPDSSKG LGPRAPASPA PAQAQTPTPA PAPASSQAPL RPEDDILYQW RQRRKLEQAQ
GSKGDRAWVP PLTPALRTLA ESLKAKALPP AAGSVIRKSE ATPSPGACLQ PEVPLSPAEQ
ATTVKASPPA FQVGSPEALA PPPPAADHAP SEALLAQAAL LLQAAEDSDG SEFQDDPVLQ
VLRAHRAELS RQKREADARL SFLLDQAEDL GSWSPPAGSP PRSPRRLLRR EGDSLEARRL
