PRSR3_MOUSE
ID PRSR3_MOUSE Reviewed; 634 AA.
AC Q7TSA6; Q8C786;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Proline and serine-rich protein 3;
GN Name=Proser3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Embryo;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-588, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7TSA6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7TSA6-2; Sequence=VSP_027704, VSP_027705, VSP_027706;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK052345; BAC34947.1; -; mRNA.
DR EMBL; BC053749; AAH53749.1; -; mRNA.
DR CCDS; CCDS21096.1; -. [Q7TSA6-1]
DR RefSeq; NP_899144.1; NM_183321.1. [Q7TSA6-1]
DR AlphaFoldDB; Q7TSA6; -.
DR STRING; 10090.ENSMUSP00000103800; -.
DR iPTMnet; Q7TSA6; -.
DR PhosphoSitePlus; Q7TSA6; -.
DR EPD; Q7TSA6; -.
DR MaxQB; Q7TSA6; -.
DR PaxDb; Q7TSA6; -.
DR PeptideAtlas; Q7TSA6; -.
DR PRIDE; Q7TSA6; -.
DR ProteomicsDB; 291756; -. [Q7TSA6-1]
DR ProteomicsDB; 291757; -. [Q7TSA6-2]
DR Antibodypedia; 44565; 40 antibodies from 12 providers.
DR DNASU; 333193; -.
DR Ensembl; ENSMUST00000062708; ENSMUSP00000059135; ENSMUSG00000036864. [Q7TSA6-1]
DR Ensembl; ENSMUST00000108165; ENSMUSP00000103800; ENSMUSG00000036864. [Q7TSA6-1]
DR GeneID; 333193; -.
DR KEGG; mmu:333193; -.
DR UCSC; uc009get.1; mouse. [Q7TSA6-1]
DR UCSC; uc009geu.1; mouse. [Q7TSA6-2]
DR CTD; 148137; -.
DR MGI; MGI:2681861; Proser3.
DR VEuPathDB; HostDB:ENSMUSG00000036864; -.
DR eggNOG; ENOG502S6GS; Eukaryota.
DR GeneTree; ENSGT00390000001986; -.
DR HOGENOM; CLU_022718_0_0_1; -.
DR InParanoid; Q7TSA6; -.
DR OrthoDB; 1610316at2759; -.
DR PhylomeDB; Q7TSA6; -.
DR TreeFam; TF337513; -.
DR BioGRID-ORCS; 333193; 6 hits in 72 CRISPR screens.
DR ChiTaRS; Proser3; mouse.
DR PRO; PR:Q7TSA6; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q7TSA6; protein.
DR Bgee; ENSMUSG00000036864; Expressed in undifferentiated genital tubercle and 62 other tissues.
DR ExpressionAtlas; Q7TSA6; baseline and differential.
DR InterPro; IPR037646; PROSER3.
DR PANTHER; PTHR22045; PTHR22045; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..634
FT /note="Proline and serine-rich protein 3"
FT /id="PRO_0000299483"
FT REGION 1..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 81..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 185..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 368..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 472..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..414
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 588
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 115
FT /note="L -> LA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027704"
FT VAR_SEQ 222..224
FT /note="APG -> GKG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027705"
FT VAR_SEQ 225..634
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027706"
SQ SEQUENCE 634 AA; 67263 MW; A81B3C419E16E264 CRC64;
MFPKVDNPLG HQETRTGATR SQRPQAPKAT AASSDELSEE SWPSSSWTPS PASTTEGQST
SPPCNLIDNE DSIVAKYINR FRQAQPTSRE DRQPAGPTSA DFWWLQPTAD SSGHLAAGAG
EPTGRSAVTG PSPTGVSSTS LASAPLQKVK QSLNSWNSSL LDLETLSLQS RAARLLKRSK
ASLNDASSSS FPISSDGLSP SSVTFNPDSN KSSNPKEPVL GAPGPSQAIP APRPASSQAT
LKPEDDILYQ WRQRRKLEQS LQGAGDGTWV LPRMPALTTQ TPPVSAVNLG SQDTQPNCTA
PCGSVAQPPP SQAFYMERPP LSGPSPHIWA PGTHGVLWAP QANPWVSFGM LPTTLLTSTL
APLASFPVPP TSTSTTPAPT PTPQVCIPGP PTSAPPPCAS TPASTLPLPD TPQGPAIPEL
SSSIQPKKVG PKPRRVSTSS HQKTTVPDTT AFEGPCSQLR GALSQVVTAR LFPDSPEDTP
PSEADFRKVQ AIPSQAKVLR PPPESRRGSK TESRKSQVTL PADAGDPQPA TAPKASTLLE
VQPREFKMSA PRMGAGDPLT IVPPASSHAP SEDLLSQATK LLQAAEDSDG SEFQEDPVLQ
LLRAQRAELR QQKRWMPSYL SSWTTLKTRD LRLL
