ID   PRSW_OCEIH              Reviewed;         215 AA.
AC   Q8EQA1;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Protease PrsW;
DE            EC=3.4.-.-;
DE   AltName: Full=Protease responsible for activating sigma-W;
GN   Name=prsW; OrderedLocusNames=OB1807;
OS   Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC
OS   3954 / HTE831).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Oceanobacillus.
OX   NCBI_TaxID=221109;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831;
RX   PubMed=12235376; DOI=10.1093/nar/gkf526;
RA   Takami H., Takaki Y., Uchiyama I.;
RT   "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge
RT   and its unexpected adaptive capabilities to extreme environments.";
RL   Nucleic Acids Res. 30:3927-3935(2002).
CC   -!- FUNCTION: Involved in the degradation of specific anti-sigma factors.
CC       Responsible for Site-1 cleavage of the RsiW anti-sigma factor. This
CC       results, after two other proteolytic steps catalyzed by the RasP and
CC       ClpXP proteases, in the release of SigW and the transcription
CC       activation of the genes under the control of the sigma-W factor (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the protease PrsW family. {ECO:0000305}.
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DR   EMBL; BA000028; BAC13763.1; -; Genomic_DNA.
DR   RefSeq; WP_011066205.1; NC_004193.1.
DR   AlphaFoldDB; Q8EQA1; -.
DR   STRING; 221109.22777491; -.
DR   MEROPS; M82.001; -.
DR   EnsemblBacteria; BAC13763; BAC13763; BAC13763.
DR   KEGG; oih:OB1807; -.
DR   eggNOG; COG2339; Bacteria.
DR   HOGENOM; CLU_081250_0_0_9; -.
DR   OMA; DEPYDGI; -.
DR   OrthoDB; 1626415at2; -.
DR   PhylomeDB; Q8EQA1; -.
DR   Proteomes; UP000000822; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR023596; Peptidase_PrsW_arch/bac.
DR   InterPro; IPR026898; PrsW.
DR   PANTHER; PTHR36844; PTHR36844; 1.
DR   Pfam; PF13367; PrsW-protease; 1.
DR   PIRSF; PIRSF016933; PrsW; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrolase; Membrane; Protease; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..215
FT                   /note="Protease PrsW"
FT                   /id="PRO_0000248138"
FT   TRANSMEM        1..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        24..29
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        53..98
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..128
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        151..178
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        202..215
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   215 AA;  24855 MW;  0AAC5451E15785A8 CRC64;
     MLSILSAGIA PALALLSYIY LKDKITEPIW LIIRMFILGA LLVLPIMFIQ YAISSEFNYD
     SIFIEAFFQI ALLEEFFKWF VFMFVIYQHE EFDNHYDGIV YASSLSLGFA SIENILYLIT
     NGIEYAFLRA VFPVSSHALF GIIMGYYLGK AKTHTNYKKK NLTLAFLLPF LLHGIYNFIL
     KGFSSFTLIL TPFMVLLWII ALYRLKRANE NTIIN