ID   PRT1B_HUMAN             Reviewed;         263 AA.
AC   A0A1B0GWB2;
DT   28-FEB-2018, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2016, sequence version 1.
DT   03-AUG-2022, entry version 22.
DE   RecName: Full=Proline rich transmembrane protein 1B {ECO:0000305};
GN   Name=PRRT1B {ECO:0000312|HGNC:HGNC:53642};
GN   Synonyms=IFITMD8 {ECO:0000312|HGNC:HGNC:53642};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the CD225/Dispanin family. {ECO:0000305}.
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DR   EMBL; AL160276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A1B0GWB2; -.
DR   BioMuta; ENSG00000283526; -.
DR   MassIVE; A0A1B0GWB2; -.
DR   PeptideAtlas; A0A1B0GWB2; -.
DR   Ensembl; ENST00000636672.1; ENSP00000490857.1; ENSG00000283526.1.
DR   MANE-Select; ENST00000636672.2; ENSP00000490857.1; NM_001395643.1; NP_001382572.1.
DR   GeneCards; PRRT1B; -.
DR   HGNC; HGNC:53642; PRRT1B.
DR   HPA; ENSG00000283526; Tissue enhanced (fallopian tube, lung, pancreas).
DR   neXtProt; NX_A0A1B0GWB2; -.
DR   VEuPathDB; HostDB:ENSG00000283526; -.
DR   GeneTree; ENSGT00940000163383; -.
DR   OMA; FPFPVYN; -.
DR   Pharos; A0A1B0GWB2; Tdark.
DR   PRO; PR:A0A1B0GWB2; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; A0A1B0GWB2; protein.
DR   Bgee; ENSG00000283526; Expressed in right uterine tube and 33 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   InterPro; IPR007593; CD225/Dispanin_fam.
DR   Pfam; PF04505; CD225; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..263
FT                   /note="Proline rich transmembrane protein 1B"
FT                   /id="PRO_0000443109"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..46
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   263 AA;  26769 MW;  3A334EC0397F8D33 CRC64;
     MEAGAGGAGS DTKGGGSPAT PEDPRSPAKP AAPEDPQMPA QPALPQLPRR PRTLDEDGAP
     SEDGAAGGSE PAPEDAPAQA AGEAGPVSKA AAGGAPHIGF VGEPPPYAPP DPKAAPLLYP
     PFPQVPVVLQ PAPSALFPPP AQLYPAAPTP PALFSPPAGA AFPFPVYNGP MAGVPGPATV
     EHRPLPKDYM MESVLVTLFC CLLTGLIAIV YSHEARAALG RGDLAQAEEA SRKARSLVLF
     SLLFGVFVST SWVIYVVVAL YLP