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PRT31_HYDCO
ID   PRT31_HYDCO             Reviewed;          48 AA.
AC   P83266;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Sperm protamine R3 isoform 1;
OS   Hydrolagus colliei (Spotted ratfish) (Chimaera colliei).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Holocephali; Chimaeriformes; Chimaeridae; Hydrolagus.
OX   NCBI_TaxID=7873 {ECO:0000305};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   MASS SPECTROMETRY.
RC   TISSUE=Sperm;
RX   PubMed=8875866; DOI=10.1007/bf02337524;
RA   Saperas N., Buesa C., Abian J., Vandekerckhove J., Kasinsky H.E., Chiva M.;
RT   "The primary structure of a chondrichthyan protamine: a new apparent
RT   contradiction in protamine evolution.";
RL   J. Mol. Evol. 43:528-535(1996).
CC   -!- FUNCTION: Protamines substitute for histones in the chromatin of sperm
CC       during the haploid phase of spermatogenesis. They compact sperm DNA
CC       into a highly condensed, stable and inactive complex.
CC       {ECO:0000269|PubMed:8875866}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8875866}. Chromosome
CC       {ECO:0000269|PubMed:8875866}.
CC   -!- TISSUE SPECIFICITY: Testis. {ECO:0000269|PubMed:8875866}.
CC   -!- MASS SPECTROMETRY: Mass=6041.3; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:8875866};
CC   -!- MISCELLANEOUS: Two isoforms exist, a major form and a minor form. This
CC       is the major form. {ECO:0000269|PubMed:8875866}.
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DR   AlphaFoldDB; P83266; -.
DR   SMR; P83266; -.
DR   GO; GO:0000228; C:nuclear chromosome; IEA:InterPro.
DR   GO; GO:0000786; C:nucleosome; TAS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; TAS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; TAS:UniProtKB.
DR   GO; GO:0007076; P:mitotic chromosome condensation; TAS:UniProtKB.
DR   GO; GO:0006334; P:nucleosome assembly; TAS:UniProtKB.
DR   GO; GO:0035092; P:sperm DNA condensation; IEA:InterPro.
DR   GO; GO:0007283; P:spermatogenesis; TAS:UniProtKB.
DR   InterPro; IPR012601; Spermatozal_protamine_typ.
DR   Pfam; PF08188; Protamine_3; 1.
PE   1: Evidence at protein level;
KW   Chromosome; Developmental protein; Differentiation;
KW   Direct protein sequencing; DNA condensation; DNA-binding; Nucleosome core;
KW   Nucleus; Spermatogenesis.
FT   CHAIN           1..48
FT                   /note="Sperm protamine R3 isoform 1"
FT                   /id="PRO_0000106627"
FT   REGION          1..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..32
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   48 AA;  6041 MW;  003E807371BD4D79 CRC64;
     ARRRHSMKKK RKSVRRRKTR KNQRKRKNSL GRSFKQHGFL KQPPRFRP
 
 
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