AAC3_DICDI
ID AAC3_DICDI Reviewed; 478 AA.
AC P14197; Q552A2; Q75JM2;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 25-MAY-2022, entry version 127.
DE RecName: Full=WD repeat-containing protein AAC3;
DE AltName: Full=AAC-rich mRNA clone AAC3 protein;
GN Name=AAC3; ORFNames=DDB_G0276031;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 42-478, AND DEVELOPMENTAL STAGE.
RX PubMed=2511421; DOI=10.1007/bf00332409;
RA Shaw D.R., Richter H., Giorda R., Ohmachi T., Ennis H.L.;
RT "Nucleotide sequences of Dictyostelium discoideum developmentally regulated
RT cDNAs rich in (AAC) imply proteins that contain clusters of asparagine,
RT glutamine, or threonine.";
RL Mol. Gen. Genet. 218:453-459(1989).
CC -!- DEVELOPMENTAL STAGE: The concentration of AAC-rich mRNAs is low in
CC dormant spores and growing cells, but increases during spore-
CC germination and multicellular development.
CC {ECO:0000269|PubMed:2511421}.
CC -!- MISCELLANEOUS: Several proteins derive from AAC-rich mRNA, which, due
CC to a frameshift also have ACA and CAA codons and thus are Asn-, Thr- or
CC Gln-rich.
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DR EMBL; AAFI02000014; EAL69315.1; -; Genomic_DNA.
DR EMBL; X16524; CAA34531.1; -; mRNA.
DR PIR; S05357; S05357.
DR RefSeq; XP_643326.1; XM_638234.1.
DR AlphaFoldDB; P14197; -.
DR SMR; P14197; -.
DR STRING; 44689.DDB0185151; -.
DR PaxDb; P14197; -.
DR EnsemblProtists; EAL69315; EAL69315; DDB_G0276031.
DR GeneID; 8620373; -.
DR KEGG; ddi:DDB_G0276031; -.
DR dictyBase; DDB_G0276031; -.
DR eggNOG; KOG1407; Eukaryota.
DR HOGENOM; CLU_045202_0_0_1; -.
DR InParanoid; P14197; -.
DR OMA; YQHEINE; -.
DR PhylomeDB; P14197; -.
DR PRO; PR:P14197; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0000445; C:THO complex part of transcription export complex; IBA:GO_Central.
DR GO; GO:0006406; P:mRNA export from nucleus; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR040132; Tex1/THOC3.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR22839; PTHR22839; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..478
FT /note="WD repeat-containing protein AAC3"
FT /id="PRO_0000050830"
FT REPEAT 163..202
FT /note="WD 1"
FT REPEAT 226..268
FT /note="WD 2"
FT REPEAT 270..307
FT /note="WD 3"
FT REPEAT 310..349
FT /note="WD 4"
FT REPEAT 357..396
FT /note="WD 5"
FT REPEAT 399..438
FT /note="WD 6"
FT REPEAT 440..478
FT /note="WD 7"
FT REGION 33..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 106..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 478 AA; 53771 MW; 6B67D7BFDDED38EA CRC64;
MGSRLNPSSN MYIPMNGPRG GYYGMPSMGQ LQHPLFNYQF PPGGFQHLQQ QQQQQQQQQQ
QQQQQQQQQT QVQQLHNQLH QQHNQQIQQQ AQATQQHLQT QQYLQSQIHQ QSQQSQLSNN
LNSNSKESTN IPKTNTQYTN FDSKNLDLAS RYFSECSTKD FIGNKKKSTS VAWNANGTKI
ASSGSDGIVR VWNFDPLGNS NNNNNSNNTS SNSKNNNIKE TIELKGHDGS IEKISWSPKN
NDLLASAGTD KVIKIWDVKI GKCIGTVSTN SENIDVRWSP DGQFIVACTR DDHLALIDLP
TIKTLKIYKF NGEELNQVGW DNNGDLILMA NSMGNIEAYK FLPKSTTHVK HLKTLYGHTA
SIYCMEFDPT GKYLAAGSAD SIVSLWDIED MMCVKTFIKS TFPCRSVSFS FDGQFIAASS
FESTIEIFHI ESSQPIHTIE CSGVSSLMWH PTLPLLAYAP EINENNKDPS IRVFGYHS