ID   PRTB_MUGCE              Reviewed;          33 AA.
AC   P08130;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1988, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Protamine-M6/M7;
DE   AltName: Full=Mugiline beta;
OS   Mugil cephalus (Flathead mullet) (Mugil japonicus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Mugilomorphae; Mugilidae; Mugil.
OX   NCBI_TaxID=48193;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Sperm;
RX   PubMed=3301825; DOI=10.1093/oxfordjournals.jbchem.a121943;
RA   Okamoto Y., Muta E., Ota S.;
RT   "Primary structures of M6 and M7 of mugiline beta (Mugil japonicus).";
RL   J. Biochem. 101:1017-1024(1987).
CC   -!- FUNCTION: Protamines substitute for histones in the chromatin of sperm
CC       during the haploid phase of spermatogenesis. They compact sperm DNA
CC       into a highly condensed, stable and inactive complex.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC   -!- TISSUE SPECIFICITY: Testis.
CC   -!- MISCELLANEOUS: The sequence of component M6 is shown.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; A26762; A26762.
DR   PIR; B26762; B26762.
DR   AlphaFoldDB; P08130; -.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Chromosome; Developmental protein; Differentiation;
KW   Direct protein sequencing; DNA condensation; DNA-binding; Nucleosome core;
KW   Nucleus; Spermatogenesis.
FT   PEPTIDE         1..33
FT                   /note="Protamine-M6/M7"
FT                   /id="PRO_0000044833"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         6
FT                   /note="E -> Q (in protamine-M7)"
FT   VARIANT         22
FT                   /note="I -> M"
SQ   SEQUENCE   33 AA;  4473 MW;  4B407DE638A0D29E CRC64;
     PRRRRETSRP IRRRRRARRA PIRRRRRVVR RRR