ID   PRTE_DICNO              Reviewed;         448 AA.
AC   P19577;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Extracellular serine protease;
DE            EC=3.4.21.-;
DE   Flags: Precursor; Fragment;
GN   Name=prvA;
OS   Dichelobacter nodosus (Bacteroides nodosus).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Cardiobacteriales;
OC   Cardiobacteriaceae; Dichelobacter.
OX   NCBI_TaxID=870;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=VCS 1001 / A198;
RX   PubMed=2666262; DOI=10.1016/0378-1119(89)90070-x;
RA   Moses E.K., Rood J.I., Yong W.K., Riffkin G.G.;
RT   "Molecular analysis of one of multiple protease-encoding genes from the
RT   prototype virulent strain of Bacteroides nodosus.";
RL   Gene 77:219-228(1989).
CC   -!- FUNCTION: This enzyme is a chymotrypsin-like serine protease. Degrades
CC       a variety of substrates present in the skin and hoof of the sheep,
CC       including elastin, keratin, fibrinogen and collagen. It seems to play
CC       an important role in the pathogenesis of sheep footrot.
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC   -!- SIMILARITY: Belongs to the peptidase S17 family. {ECO:0000305}.
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DR   EMBL; M26969; AAA72773.1; -; Genomic_DNA.
DR   PIR; S69783; S69783.
DR   AlphaFoldDB; P19577; -.
DR   MEROPS; X21.001; -.
DR   PRIDE; P19577; -.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Protease; Serine protease; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           21..>448
FT                   /note="Extracellular serine protease"
FT                   /id="PRO_0000028518"
FT   REGION          87..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         448
SQ   SEQUENCE   448 AA;  48154 MW;  BE52BC38441C3132 CRC64;
     MKLSHLSLAI ISAITLAACG GGNDDKPMPQ DPDNGALVEQ RNEAIKKKAT AYLEDKDGKA
     PALTKDEEAT LSQIDENLFN EYKKKQKELE NQASDDEVDP TKTGVVGNLD LGKQASQGTT
     QYVRGTKSSF DAENNPKEVS SATAILGVEA KTQNPWLTNI VLARKVRADG TVSIMQYLGN
     DGSDAADFTN VKSLQAQNDH NVVKFSDLKT NKPLDEAKLE AQKKQVDLII KLYEKIDSSE
     ITTEEKEELE KFVALKEELN AIDIKSPEGY VGLDEKAHKL FSETGASGSD DIIFGDDVPT
     NNSVLGTADT GSGAIPPVKP IYTSGKPGAD ATGAGALGLV GMNFKVGGTQ EAIQGTEEKS
     QSSTRVFGRQ YNTQSRAERK FNSYADAAVL ALSSEKDLAN AIAGITDQSE LANITADMKN
     AKINYHLAVK PQKLDYVQYG RVTGNLDP