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PRTG_HUMAN
ID   PRTG_HUMAN              Reviewed;        1150 AA.
AC   Q2VWP7; Q8N7D8;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Protogenin;
DE   AltName: Full=Protein Shen-Dan;
DE   Flags: Precursor;
GN   Name=PRTG {ECO:0000312|HGNC:HGNC:26373};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1] {ECO:0000312|EMBL:AAU05741.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Wong Y.-H., Chang C., Chen P.-H., Yu J.-Y., Wang Y.-C., Lee C.-M.,
RA   Lin W.-J., Tsai T.-F., Wang A.-G., Fann M.-J.;
RT   "Shen-Dan is a novel receptor for embryonic stem cells and developing
RT   neurons.";
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305, ECO:0000312|EMBL:BAC05355.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 603-1150, AND VARIANT LEU-1062.
RC   TISSUE=Testis {ECO:0000312|EMBL:BAC05355.1};
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- FUNCTION: May play a role in anteroposterior axis elongation.
CC       {ECO:0000250|UniProtKB:Q2EY15}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the immunoglobulin superfamily. DCC family.
CC       {ECO:0000255}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC05355.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AY630258; AAU05741.1; -; mRNA.
DR   EMBL; AK098622; BAC05355.1; ALT_INIT; mRNA.
DR   CCDS; CCDS42040.1; -.
DR   RefSeq; NP_776175.2; NM_173814.5.
DR   AlphaFoldDB; Q2VWP7; -.
DR   SMR; Q2VWP7; -.
DR   BioGRID; 129634; 10.
DR   IntAct; Q2VWP7; 4.
DR   MINT; Q2VWP7; -.
DR   STRING; 9606.ENSP00000373937; -.
DR   GlyGen; Q2VWP7; 5 sites, 1 O-linked glycan (1 site).
DR   iPTMnet; Q2VWP7; -.
DR   PhosphoSitePlus; Q2VWP7; -.
DR   BioMuta; PRTG; -.
DR   DMDM; 121946850; -.
DR   EPD; Q2VWP7; -.
DR   jPOST; Q2VWP7; -.
DR   MassIVE; Q2VWP7; -.
DR   PaxDb; Q2VWP7; -.
DR   PeptideAtlas; Q2VWP7; -.
DR   PRIDE; Q2VWP7; -.
DR   ProteomicsDB; 61526; -.
DR   Antibodypedia; 52034; 73 antibodies from 13 providers.
DR   DNASU; 283659; -.
DR   Ensembl; ENST00000389286.9; ENSP00000373937.4; ENSG00000166450.13.
DR   GeneID; 283659; -.
DR   KEGG; hsa:283659; -.
DR   MANE-Select; ENST00000389286.9; ENSP00000373937.4; NM_173814.6; NP_776175.2.
DR   UCSC; uc002adg.4; human.
DR   CTD; 283659; -.
DR   DisGeNET; 283659; -.
DR   GeneCards; PRTG; -.
DR   HGNC; HGNC:26373; PRTG.
DR   HPA; ENSG00000166450; Tissue enhanced (retina, thyroid gland).
DR   MIM; 613261; gene.
DR   neXtProt; NX_Q2VWP7; -.
DR   OpenTargets; ENSG00000166450; -.
DR   PharmGKB; PA142671124; -.
DR   VEuPathDB; HostDB:ENSG00000166450; -.
DR   eggNOG; KOG4221; Eukaryota.
DR   GeneTree; ENSGT00940000155943; -.
DR   HOGENOM; CLU_006906_1_0_1; -.
DR   InParanoid; Q2VWP7; -.
DR   OMA; PMNCTTI; -.
DR   OrthoDB; 1010015at2759; -.
DR   PhylomeDB; Q2VWP7; -.
DR   TreeFam; TF321506; -.
DR   PathwayCommons; Q2VWP7; -.
DR   SignaLink; Q2VWP7; -.
DR   BioGRID-ORCS; 283659; 14 hits in 1070 CRISPR screens.
DR   ChiTaRS; PRTG; human.
DR   GenomeRNAi; 283659; -.
DR   Pharos; Q2VWP7; Tbio.
DR   PRO; PR:Q2VWP7; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   RNAct; Q2VWP7; protein.
DR   Bgee; ENSG00000166450; Expressed in buccal mucosa cell and 141 other tissues.
DR   ExpressionAtlas; Q2VWP7; baseline and differential.
DR   Genevisible; Q2VWP7; HS.
DR   GO; GO:0005615; C:extracellular space; HDA:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:Ensembl.
DR   GO; GO:0050768; P:negative regulation of neurogenesis; IEA:Ensembl.
DR   CDD; cd00063; FN3; 5.
DR   Gene3D; 2.60.40.10; -; 9.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   Pfam; PF00041; fn3; 5.
DR   Pfam; PF07679; I-set; 2.
DR   SMART; SM00060; FN3; 5.
DR   SMART; SM00409; IG; 4.
DR   SMART; SM00408; IGc2; 4.
DR   SUPFAM; SSF48726; SSF48726; 4.
DR   SUPFAM; SSF49265; SSF49265; 3.
DR   PROSITE; PS50853; FN3; 5.
DR   PROSITE; PS50835; IG_LIKE; 4.
PE   2: Evidence at transcript level;
KW   Developmental protein; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW   Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000255"
FT   CHAIN           36..1150
FT                   /note="Protogenin"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000317047"
FT   TOPO_DOM        36..949
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        950..970
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        971..1150
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          36..130
FT                   /note="Ig-like 1"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          135..222
FT                   /note="Ig-like 2"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          235..322
FT                   /note="Ig-like 3"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          327..411
FT                   /note="Ig-like 4"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          421..515
FT                   /note="Fibronectin type-III 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   DOMAIN          517..613
FT                   /note="Fibronectin type-III 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   DOMAIN          618..717
FT                   /note="Fibronectin type-III 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   DOMAIN          724..817
FT                   /note="Fibronectin type-III 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   DOMAIN          822..917
FT                   /note="Fibronectin type-III 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   REGION          981..1002
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1086..1150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1086..1105
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1115..1135
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1136..1150
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        90
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        488
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        630
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        60..113
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        156..205
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        256..304
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        348..395
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   VARIANT         236
FT                   /note="T -> A (in dbSNP:rs16976466)"
FT                   /id="VAR_049916"
FT   VARIANT         826
FT                   /note="V -> L (in dbSNP:rs10518816)"
FT                   /id="VAR_049917"
FT   VARIANT         1062
FT                   /note="I -> L (in dbSNP:rs1438914)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_038467"
SQ   SEQUENCE   1150 AA;  127076 MW;  F64CBA30C0F1EC89 CRC64;
     MAPPLRPLAR LRPPGMLLRA LLLLLLLSPL PGVWCFSELS FVKEPQDVTV TRKDPVVLDC
     QAHGEVPIKV TWLKNGAKMS ENKRIEVLSN GSLYISEVEG RRGEQSDEGF YQCLAMNKYG
     AILSQKAHLA LSTISAFEVQ PISTEVHEGG VARFACKISS HPPAVITWEF NRTTLPMTMD
     RITALPTGVL QIYDVSQRDS GNYRCIAATV AHRRKSMEAS LTVIPAKESK SFHTPTIIAG
     PQNITTSLHQ TVVLECMATG NPKPIISWSR LDHKSIDVFN TRVLGNGNLM ISDVRLQHAG
     VYVCRATTPG TRNFTVAMAT LTVLAPPSFV EWPESLTRPR AGTARFVCQA EGIPSPKMSW
     LKNGRKIHSN GRIKMYNSKL VINQIIPEDD AIYQCMAENS QGSILSRARL TVVMSEDRPS
     APYNVHAETM SSSAILLAWE RPLYNSDKVI AYSVHYMKAE GLNNEEYQVV IGNDTTHYII
     DDLEPASNYT FYIVAYMPMG ASQMSDHVTQ NTLEDVPLRP PEISLTSRSP TDILISWLPI
     PAKYRRGQVV LYRLSFRLST ENSIQVLELP GTTHEYLLEG LKPDSVYLVR ITAATRVGLG
     ESSVWTSHRT PKATSVKAPK SPELHLEPLN CTTISVRWQQ DVEDTAAIQG YKLYYKEEGQ
     QENGPIFLDT KDLLYTLSGL DPRRKYHVRL LAYNNIDDGY QADQTVSTPG CVSVRDRMVP
     PPPPPHHLYA KANTSSSIFL HWRRPAFTAA QIINYTIRCN PVGLQNASLV LYLQTSETHM
     LVQGLEPNTK YEFAVRLHVD QLSSPWSPVV YHSTLPEAPA GPPVGVKVTL IEDDTALVSW
     KPPDGPETVV TRYTILYASR KAWIAGEWQV LHREGAITMA LLENLVAGNV YIVKISASNE
     VGEGPFSNSV ELAVLPKETS ESNQRPKRLD SADAKVYSGY YHLDQKSMTG IAVGVGIALT
     CILICVLILI YRSKARKSSA SKTAQNGTQQ LPRTSASLAS GNEVGKNLEG AVGNEESLMP
     MIMPNSFIDA KGGTDLIINS YGPIIKNNSK KKWFFFQDSK KIQVEQPQRR FTPAVCFYQP
     GTTVLISDED SPSSPGQTTS FSRPFGVAAD TEHSANSEGS HETGDSGRFS HESNDEIHLS
     SVISTTPPNL
 
 
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