PRTG_RAT
ID PRTG_RAT Reviewed; 1193 AA.
AC Q2VWP9;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Protogenin;
DE AltName: Full=Protein Shen-Dan;
DE Flags: Precursor;
GN Name=Prtg {ECO:0000250|UniProtKB:Q2EY15};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000312|EMBL:AAU05739.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Neural tube {ECO:0000312|EMBL:AAU05739.1};
RA Wong Y.-H., Chang C., Chen P.-H., Yu J.-Y., Wang Y.-C., Lee C.-M.,
RA Lin W.-J., Tsai T.-F., Wang A.-G., Fann M.-J.;
RT "Shen-Dan is a novel receptor for embryonic stem cells and developing
RT neurons.";
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in anteroposterior axis elongation.
CC {ECO:0000250|UniProtKB:Q2EY15}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. DCC family.
CC {ECO:0000255}.
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DR EMBL; AY630256; AAU05739.1; -; mRNA.
DR RefSeq; NP_001032740.1; NM_001037651.1.
DR AlphaFoldDB; Q2VWP9; -.
DR SMR; Q2VWP9; -.
DR STRING; 10116.ENSRNOP00000036541; -.
DR GlyGen; Q2VWP9; 3 sites.
DR PaxDb; Q2VWP9; -.
DR GeneID; 315806; -.
DR KEGG; rno:315806; -.
DR UCSC; RGD:1307157; rat.
DR CTD; 283659; -.
DR RGD; 1307157; Prtg.
DR eggNOG; KOG4221; Eukaryota.
DR InParanoid; Q2VWP9; -.
DR OrthoDB; 1010015at2759; -.
DR PhylomeDB; Q2VWP9; -.
DR PRO; PR:Q2VWP9; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0038023; F:signaling receptor activity; ISO:RGD.
DR GO; GO:0007411; P:axon guidance; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0050768; P:negative regulation of neurogenesis; ISO:RGD.
DR CDD; cd00063; FN3; 5.
DR Gene3D; 2.60.40.10; -; 9.
DR InterPro; IPR043204; Basigin-like.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR033011; Protogenin.
DR PANTHER; PTHR10075; PTHR10075; 1.
DR PANTHER; PTHR10075:SF75; PTHR10075:SF75; 1.
DR Pfam; PF00041; fn3; 5.
DR Pfam; PF07679; I-set; 3.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF48726; SSF48726; 4.
DR SUPFAM; SSF49265; SSF49265; 3.
DR PROSITE; PS50853; FN3; 5.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 2: Evidence at transcript level;
KW Developmental protein; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..1193
FT /note="Protogenin"
FT /evidence="ECO:0000255"
FT /id="PRO_0000317048"
FT TOPO_DOM 24..944
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 945..965
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 966..1193
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 24..124
FT /note="Ig-like 1"
FT /evidence="ECO:0000255"
FT DOMAIN 126..217
FT /note="Ig-like 2"
FT /evidence="ECO:0000255"
FT DOMAIN 230..317
FT /note="Ig-like 3"
FT /evidence="ECO:0000255"
FT DOMAIN 322..406
FT /note="Ig-like 4"
FT /evidence="ECO:0000255"
FT DOMAIN 416..510
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 512..608
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 613..712
FT /note="Fibronectin type-III 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 719..812
FT /note="Fibronectin type-III 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 817..912
FT /note="Fibronectin type-III 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REGION 974..1018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1078..1193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 974..991
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1078..1109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1110..1130
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1131..1152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 84
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 238
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 625
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 54..107
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 150..200
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 251..299
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 343..390
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 1193 AA; 131080 MW; 8936A811894236C8 CRC64;
MAPPVRPGML PLLLLLLLPP LGSVPGVWSF SELFFMKEPQ DATVTRKDPV FLDCQAHGEG
PIKVTWLKNG AKLSENKRIQ VLSNGSLYIS EAEGRRGEQS DEGFYQCLAV NKYGAILSQK
AHLTLSTISA FEVHPVSTEV PEGGVARFSC KISSTPPAVI TWEFNRTALP MTMDSRVTAL
PSGVLQIYDA GPEDAGKYRC VAATHAHKRK SMEASLTIVP ANETRSFYMP TIIASPQNVT
ASLHQTVVLE CMATGYPKPI ISWSRLDHKS IDVFNTRVLG NGNLIISDVK LQHAGVYVCR
ATTPGTRNFT VAMATLTVLA PPSFVEWPES LTRPRAGTAR FVCQAEGIPS PKMSWLKNGR
RIHSNGRIKM YNSKLVINQI IPEDDAIYQC MAENSQGSVL SRARLTVVMS EDRPSAPYNV
HAETMSSSAI LLAWERPLYN SDKVIAYSVH YMKAEGLNNE EYQVVLGNDT THYIIDDLEP
DSNYTFYIVA YMPMGASQMS DHVTQNTLED VPLRPPEISL TSRSPTDILI SWLPIPAKYR
RGQVVLYRLS FRLSTENSIQ VVELPGTVHE YLLEGLEPDS VYLVRITAAT RVGLGESSVW
TSHRTPKATS VKAPKSPELH LEPLNCTTIS VRWLQDTEDP AAIRGYKLFY KEEGQQEHGP
IFLDTGDLLY TLSGLDPRRK YHVRLLAYNN LEDGYQADQT VSTPGCVSVR DRMVPPPPPP
HHLYAKANTS SSIFLHWRRP AFTTAQVINY TIRCNPVGLQ NASLVLYLQT SETHMLVQGL
EPNTKYEFAV RLHVDQLSSP WSPVVYHTTL PEAPTGPPVG VKVTLIEDDT ALVSWKPPDG
PETVVTRYTI LYASRKAWIA GEWQVLHREG AITMALLENL VAGNVYIVKI SASNEVGEGP
FPNSVELAVL PKDASESNQR PKRLDSSDAK VYSGYYHLDQ KSMTGIAVGV GIALTCILIC
VLILIYRSKA RKSSASKTTQ SGTQPLSRAS ASVAAGSDMG KNLERATENE ESSVPMMPSC
FIDAKGGTDL IINSYGPIIK NNPKKKWRFF QDTKKIKVEQ TQRRITQTVC FYQPGTTVLI
SDEDSPSSPG QTTSFPRPFG PTTLDTEHSA NSEGSHETGD SGRFSHESND EIHLSSVISS
TPPTSNSLTC GDSDGDAAPK KHGDPAQPLP AEQTSAPQPT PAGLRHAAES VPV
