ID   PRTR_PSEAE              Reviewed;         256 AA.
AC   Q06553;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=HTH-type transcriptional regulator PrtR;
DE   AltName: Full=Pyocin repressor protein;
GN   Name=prtR; OrderedLocusNames=PA0611;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8444788; DOI=10.1128/jb.175.5.1257-1263.1993;
RA   Matsui H., Sano Y., Ishihara H., Shinomiya T.;
RT   "Regulation of pyocin genes in Pseudomonas aeruginosa by positive (prtN)
RT   and negative (prtR) regulatory genes.";
RL   J. Bacteriol. 175:1257-1263(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1, and PML14;
RA   Nakayama K., Takashima K., Ishihara H., Shinomiya T., Kageyama M.,
RA   Kanaya S., Ohnishi M., Murata T., Terawaki Y., Mori H., Hayashi T.;
RT   "Genetic relationship between bacteriocins and bacteriophages.";
RL   Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Represses the promoter activity of the prtN gene.
CC   -!- INDUCTION: Inactivated by the activated RecA protein after UV
CC       irradiation.
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DR   EMBL; D12706; BAA02198.1; -; Genomic_DNA.
DR   EMBL; AB030825; BAA83146.1; -; Genomic_DNA.
DR   EMBL; AB030826; BAA83132.1; -; Genomic_DNA.
DR   EMBL; AE004091; AAG04000.1; -; Genomic_DNA.
DR   PIR; A47062; A47062.
DR   RefSeq; NP_249302.1; NC_002516.2.
DR   RefSeq; WP_003113202.1; NZ_QZGE01000010.1.
DR   AlphaFoldDB; Q06553; -.
DR   STRING; 287.DR97_3580; -.
DR   PaxDb; Q06553; -.
DR   PRIDE; Q06553; -.
DR   EnsemblBacteria; AAG04000; AAG04000; PA0611.
DR   GeneID; 879679; -.
DR   KEGG; pae:PA0611; -.
DR   PATRIC; fig|208964.12.peg.647; -.
DR   PseudoCAP; PA0611; -.
DR   HOGENOM; CLU_066192_1_4_6; -.
DR   InParanoid; Q06553; -.
DR   OMA; HVNNWFK; -.
DR   PhylomeDB; Q06553; -.
DR   BioCyc; PAER208964:G1FZ6-618-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030152; P:bacteriocin biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:1900377; P:negative regulation of secondary metabolite biosynthetic process; IMP:PseudoCAP.
DR   CDD; cd00093; HTH_XRE; 1.
DR   CDD; cd06529; S24_LexA-like; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR039418; LexA-like.
DR   InterPro; IPR036286; LexA/Signal_pep-like_sf.
DR   InterPro; IPR015927; Peptidase_S24_S26A/B/C.
DR   Pfam; PF01381; HTH_3; 1.
DR   Pfam; PF00717; Peptidase_S24; 1.
DR   SMART; SM00530; HTH_XRE; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF51306; SSF51306; 1.
DR   PROSITE; PS50943; HTH_CROC1; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic biosynthesis; Bacteriocin biosynthesis; DNA-binding;
KW   Reference proteome; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..256
FT                   /note="HTH-type transcriptional regulator PrtR"
FT                   /id="PRO_0000149730"
FT   DOMAIN          16..69
FT                   /note="HTH cro/C1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT   DNA_BIND        27..46
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
SQ   SEQUENCE   256 AA;  28112 MW;  C4555438B3162637 CRC64;
     MDKSTQIPPD SFAARLKQAM AMRNLKQETL AEAAGVSQNT IHKLTSGKAQ STRKLIEIAA
     ALGVSPVWLQ TGEGAPAARS AVSVADGSPL VLEPLHPWDS DTPLDEDEVE LPLYKEVEMS
     AGAGRTAVRE IEGRKLRFSY ATLRASGVDP SAAICAQLTG NSMEPLIMDG STIGVDTATT
     HITDGEIYAL EHDGMLRVKF VYRLPGGGIR LRSFNREEYP DEEYSPEDMR SRQISMIGWV
     FWWSTVRHRR GPSLVR