ID   PRTT_ASPFU              Reviewed;         696 AA.
AC   Q4WPQ8;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Transcriptional activator of proteases prtT;
DE   AltName: Full=Zn(2)-C6 zinc finger-containing protein prtT;
GN   Name=prtT; ORFNames=AFUA_4G10120;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
RN   [2]
RP   FUNCTION.
RX   PubMed=19564390; DOI=10.1128/iai.00425-09;
RA   Bergmann A., Hartmann T., Cairns T., Bignell E.M., Krappmann S.;
RT   "A regulator of Aspergillus fumigatus extracellular proteolytic activity is
RT   dispensable for virulence.";
RL   Infect. Immun. 77:4041-4050(2009).
RN   [3]
RP   FUNCTION.
RX   PubMed=19564385; DOI=10.1128/iai.00426-09;
RA   Sharon H., Hagag S., Osherov N.;
RT   "Transcription factor PrtT controls expression of multiple secreted
RT   proteases in the human pathogenic mold Aspergillus fumigatus.";
RL   Infect. Immun. 77:4051-4060(2009).
CC   -!- FUNCTION: Transcription factor required for protein utilization and
CC       degradation. Regulates transcription of major secreted proteases
CC       including a serine alkaline protease (alk1), a metalloprotease (mep),
CC       an aspergillopepsin (pep1), a sedolisin (sed2) and two dipeptidyl-
CC       peptidases (dppIV and dppV). However, it is not a virulence determinant
CC       in leukopenic mice. {ECO:0000269|PubMed:19564385,
CC       ECO:0000269|PubMed:19564390}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the prtT family. {ECO:0000305}.
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DR   EMBL; AAHF01000005; EAL89776.1; -; Genomic_DNA.
DR   RefSeq; XP_751814.1; XM_746721.1.
DR   AlphaFoldDB; Q4WPQ8; -.
DR   STRING; 746128.CADAFUBP00006543; -.
DR   EnsemblFungi; EAL89776; EAL89776; AFUA_4G10120.
DR   GeneID; 3509345; -.
DR   KEGG; afm:AFUA_4G10120; -.
DR   VEuPathDB; FungiDB:Afu4g10120; -.
DR   eggNOG; ENOG502QU5T; Eukaryota.
DR   HOGENOM; CLU_030102_0_0_1; -.
DR   InParanoid; Q4WPQ8; -.
DR   OMA; EMTSMMR; -.
DR   OrthoDB; 429712at2759; -.
DR   PHI-base; PHI:2809; -.
DR   PHI-base; PHI:2828; -.
DR   Proteomes; UP000002530; Chromosome 4.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:UniProtKB.
DR   GO; GO:0030163; P:protein catabolic process; IMP:AspGD.
DR   GO; GO:0042176; P:regulation of protein catabolic process; IMP:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..696
FT                   /note="Transcriptional activator of proteases prtT"
FT                   /id="PRO_0000407032"
FT   DNA_BIND        136..165
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          106..126
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        109..123
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   696 AA;  78951 MW;  2FE4E040917CB289 CRC64;
     MMHIQTLRKI TILDVQDKQR CLSTNQNVPD NVFQLIACWC YFPPFLSIAK IKPLIALKAG
     ISENPVLIGC RRIKMAHCPY SEAMTRTTSV EDVKFEIPAW DNSNVDVADG SGRPESSTSG
     DTIRPKGRIR RSMTACNTCR KLKTRCDLDP RGHACRRCLS LRIECKLPET AERFQDNASM
     WSDATAAIPS IEERLISLER SMTEMTSMMR RMMDRSPSIS GSSVSMLTRS GITDETASIE
     GSQSSSFAPR PIRLFQDLQS DFTGEANVLP ADSRSLGDLF TKGIIDPKLS QKLIQLFVDH
     FGIWISVDNP SDIHNELRAT DPLLYSTACL LASRYVPGIP LSVIHAMYLQ IRHATVNVLW
     NKTPLKHETL QALALLALWP TAVQKETPMD SWLLSGISIN HAIISFDFLN HAPSDLIVDN
     DMVAKLRVWN ALCLTQLQSA IGNARPFHIQ QRYLEHCPRL LEHPAATFED GKIVAEIQLY
     LIALKLQNFS HRMRLGDFEY EEIERWKMEW AHLLKLSLWY CQLLLYRTAM RFHWESEHLI
     SEILRNSRLI LSKFLLVRFP NALAFPDQIY YIVGYAALNL CDFSPMDPLI DQVQTFLLHL
     SPNEDHIAYR FSYTITELKR RCATGPNPHN VVKGAFGDTR KLSMGQQIPF MNPLMDTMMG
     EYGGLEHLIP EVPPNSLPDM LTSVAGELQA FRTAIL