PRTT_ASPOR
ID PRTT_ASPOR Reviewed; 641 AA.
AC A7BJS7; Q2UJH4; Q2UJH5;
DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 1.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Transcriptional activator of proteases prtT;
DE AltName: Full=Zn(2)-C6 zinc finger-containing protein prtT;
GN Name=prtT; Synonyms=prtR; ORFNames=AO090003001211/AO090003001212;
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40;
RA Gomi K., Matsuura T.;
RT "A novel transcription activator, PrtR, involved in expression of major
RT proteolytic genes in Aspergillus oryzae.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40;
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
RN [3]
RP FUNCTION.
RX PubMed=18930158; DOI=10.1016/j.fgb.2008.09.007;
RA Punt P.J., Schuren F.H., Lehmbeck J., Christensen T., Hjort C.,
RA van den Hondel C.A.;
RT "Characterization of the Aspergillus niger prtT, a unique regulator of
RT extracellular protease encoding genes.";
RL Fungal Genet. Biol. 45:1591-1599(2008).
CC -!- FUNCTION: Transcription factor required for protein utilization and
CC degradation. Regulates transcription of major secreted proteases
CC including a serine alkaline protease (alp1) and a metalloprotease
CC (NpI). {ECO:0000269|PubMed:18930158}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC -!- SIMILARITY: Belongs to the prtT family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE58290.1; Type=Erroneous gene model prediction; Note=The predicted genes AO090003001211 and AO090003001212 have been merged.; Evidence={ECO:0000305};
CC Sequence=BAE58291.1; Type=Erroneous gene model prediction; Note=The predicted genes AO090003001211 and AO090003001212 have been merged.; Evidence={ECO:0000305};
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DR EMBL; AB333776; BAF74781.1; -; Genomic_DNA.
DR EMBL; AP007155; BAE58290.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP007155; BAE58291.1; ALT_SEQ; Genomic_DNA.
DR AlphaFoldDB; A7BJS7; -.
DR Proteomes; UP000006564; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:UniProtKB.
DR GO; GO:0042176; P:regulation of protein catabolic process; IMP:UniProtKB.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..641
FT /note="Transcriptional activator of proteases prtT"
FT /id="PRO_0000407034"
FT DNA_BIND 52..81
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
SQ SEQUENCE 641 AA; 72655 MW; 5FC8D5EA26849C26 CRC64;
MTRTTVEPIK YEAPSWEHKS VHVSDDHRRI IPNVGDDATR PKGRIRRSMT ACNTCRKLKT
RCDLDPRGHA CRRCLSLRID CQLPETSERF QDSTPMWSDA TTAIPSIEER LTSLERSMRE
MTGMLRQILN QSPSVSNISV PPLARSVHTE ETASIEGNSF GPFLPKPVRL IQDLQSEFFG
ETNRIPVESP FLGNSFEKGI LDSKLSLKLV QLFVDNFGPL VSINNQSDFH NEMRNTDSLL
YSTACLLASR YVPGIPPPIV HTMNLQVRHK AVNLLWEKPP LKYESLQALA LLCLWPAAGQ
KEFPIDGWLL SGTAINHALV SFDFLNHVPS ELLIDNDIAA QLRLWNAFCL TQLHFAVGNA
RPFHLPQRYL DYCPRLLEHP AATVEDGKVV AEIQLYLITL RLQANEQRMR FAEVEYEEIE
RWKVEWAHLL GKVKQRGPSR INANYSTAGD ENSTFELSLW FCQILLHRTA MRFQAESERL
TSEILQGSRL IISKFLQLRF VTALRVVDQA YFIVGYAALN LCDFNFLDPL IDQIQMFLLH
LSPNEDHIAY RFSCMIAEFK RRCAECNDPC SAVDGSQCSF GDARKMSMEQ VQFVPPLVDS
MIGGYSALEQ LIPEVMPHSF PESVISGMAV TEAIPVGSAP Y