ID   PRTT_EMENI              Reviewed;         660 AA.
AC   Q5B8L0; C8VIK0;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Transcriptional activator of proteases prtT;
DE   AltName: Full=Zn(2)-C6 zinc finger-containing protein prtT;
GN   Name=prtT; ORFNames=AN3120;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- FUNCTION: Transcription factor required for protein utilization and
CC       degradation. Regulates transcription of major secreted proteases (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the prtT family. {ECO:0000305}.
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DR   EMBL; AACD01000051; EAA63691.1; -; Genomic_DNA.
DR   EMBL; BN001306; CBF83371.1; -; Genomic_DNA.
DR   RefSeq; XP_660724.1; XM_655632.1.
DR   AlphaFoldDB; Q5B8L0; -.
DR   EnsemblFungi; CBF83371; CBF83371; ANIA_03120.
DR   EnsemblFungi; EAA63691; EAA63691; AN3120.2.
DR   GeneID; 2873801; -.
DR   KEGG; ani:AN3120.2; -.
DR   eggNOG; ENOG502QW6D; Eukaryota.
DR   HOGENOM; CLU_011003_0_1_1; -.
DR   InParanoid; Q5B8L0; -.
DR   OMA; ETLNRCY; -.
DR   OrthoDB; 659306at2759; -.
DR   Proteomes; UP000000560; Chromosome VI.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..660
FT                   /note="Transcriptional activator of proteases prtT"
FT                   /id="PRO_0000407035"
FT   DNA_BIND        38..67
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          112..163
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        112..140
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   660 AA;  73604 MW;  8ADD1F689C0B5E7A CRC64;
     MKRSSFDAGL DGRQQDRRHS AVPDERPTPL KISKARACAE CKRHKIRCEF RPGETSCTKC
     LRSGIKCVVN DFSQKFVDDD GVWKARASAT IQQLQAAVSH LLRQNGLPEL STYTVGDSPN
     GPSPAAPSYH TGNRHSMNGS PSDVKPDGPG LVVTREPSQE PDLQDRELVP APMRSLYEVT
     KLRDLRHNHI EQPKSTLLEE DFLSRGLISL QEAEELFAYF SRTMNQLLWG GIILVHRDLT
     SVRRASSLLA AAVLTVAALH IPNRTETLNL CYSEYVSLVS SMSLTRAHTL DDVRALCVGA
     FWLSELSWKL SGHAVRIATE LGLHQSYQKM IRGHSDQYER AQLWYLLYVC DHHFSIAYGR
     PPVIHEDQAI KNYETFLQAP MVVPGDIRLL AQVALFMILT EAYRTFGSDT EQALTEEDFG
     QLRVFNVAID QWRLLWQPRS EYLTLAAADS PYVRTYPSKG VVLHYHFAKF QLNSLSLRAL
     SPTNTPVFSM DRKESANIAI SSAMACLNMV LEEQDIRDAI VGVPIFTHTM VTFSALFLLK
     VAVNWNSAYL SLDSGLVRSL VERVIELLNC VSAGERHLTR HIARGLSKML ERFDSWDMSN
     GVPAGTVGER AGSGVPGGAN AMAQGFPPPD LIYDMVGTYG FGLDENLLDP SMANFEYLAQ