ID   PRTT_PENRW              Reviewed;         637 AA.
AC   B6HRH5;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Transcriptional activator of proteases prtT;
DE   AltName: Full=Zn(2)-C6 zinc finger-containing protein prtT;
GN   Name=prtT; ORFNames=Pc22g12330;
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS   54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255;
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA   van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA   Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- FUNCTION: Transcription factor required for protein utilization and
CC       degradation. Regulates transcription of major secreted proteases (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the prtT family. {ECO:0000305}.
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DR   EMBL; AM920437; CAP98521.1; -; Genomic_DNA.
DR   RefSeq; XP_002565177.1; XM_002565131.1.
DR   AlphaFoldDB; B6HRH5; -.
DR   PRIDE; B6HRH5; -.
DR   EnsemblFungi; CAP98521; CAP98521; PCH_Pc22g12330.
DR   GeneID; 8309568; -.
DR   KEGG; pcs:Pc22g12330; -.
DR   VEuPathDB; FungiDB:PCH_Pc22g12330; -.
DR   eggNOG; ENOG502QU5T; Eukaryota.
DR   HOGENOM; CLU_030102_0_0_1; -.
DR   OMA; EMTSMMR; -.
DR   OrthoDB; 429712at2759; -.
DR   BioCyc; PCHR:PC22G12330-MON; -.
DR   Proteomes; UP000000724; Contig Pc00c22.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..637
FT                   /note="Transcriptional activator of proteases prtT"
FT                   /id="PRO_0000407036"
FT   DNA_BIND        47..76
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          127..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   637 AA;  70953 MW;  CB3245B3F75C54A4 CRC64;
     MTRTGPPINP ISWDTKTIVP DDGSRIDSVA CQDARPKGRI RRSMTACHTC RKLKTRCDVD
     PRGHSCRRCL SLRLDCELPE TTERFQDNAS TWSDATAVPS IEERLVSLER GMGEMIHLMR
     QIVKSSPSMP CSPTFQTRNH SIDGTSSSDS MSSSFYPLKP AQLIRDLQAE CFGERAHFSD
     ADILGDIVTQ GIVDSKLSVK LIELFVEHFG HWVSINHSSS LQRSNTLLFN TACLLASRYM
     PGLPQHTVRD ISLYVQHAVA KVLWKPPPMT SDMLQALTLL CLYSTSIHKE GLMDDWLLSG
     ISINHALISF NFLNTLPGDN LSPDELLAQL RLWNTLCATQ LHSALANGRT VNIQQQYINQ
     CPRILEHAGA TPEDGRIVAE IQLYRIALRL QHSQSRLQFA ESEYEELERW RMEWAHLLTT
     NGDSTLNLNL WFCQLLLHRT AARLQPDSER LLPEICGTAR LIITQFLQTR FTSAPALIDH
     VYFIVGYAAL TLCDYTLTDP LINQVRGFLL HLAPGGDNLS YRIACIVGEV QRRYSEATAV
     VAAGSHSSSP VAEVKGAQMF GSSHHHRTGM ELSQLMSSPE GLDSLVEGYN CLEQMMPGYA
     ASQPAFEAPD LFHHSPTTGV TGGAMPIGLV PRALHDW