ID   PRTT_SERMA              Reviewed;        1045 AA.
AC   P29805;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Extracellular serine protease;
DE            EC=3.4.21.-;
DE   Flags: Precursor;
OS   Serratia marcescens.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Serratia.
OX   NCBI_TaxID=615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=RH1;
RA   Lee S., Kim J., Kho Y., Rho H.M.;
RL   Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000305}.
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DR   EMBL; X59719; CAA42236.1; -; Genomic_DNA.
DR   PIR; S19882; SUSEMM.
DR   AlphaFoldDB; P29805; -.
DR   SMR; P29805; -.
DR   MEROPS; S08.094; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019867; C:outer membrane; IEA:InterPro.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd04848; Peptidases_S8_Autotransporter_serine_protease_like; 1.
DR   Gene3D; 2.40.128.130; -; 1.
DR   Gene3D; 3.40.50.200; -; 1.
DR   InterPro; IPR005546; Autotransporte_beta.
DR   InterPro; IPR036709; Autotransporte_beta_dom_sf.
DR   InterPro; IPR013425; Autotrns_rpt.
DR   InterPro; IPR006315; OM_autotransptr_brl.
DR   InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR034061; Peptidases_S8_Autotransporter.
DR   Pfam; PF03797; Autotransporter; 1.
DR   Pfam; PF12951; PATR; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SMART; SM00869; Autotransporter; 1.
DR   SUPFAM; SSF103515; SSF103515; 1.
DR   SUPFAM; SSF51126; SSF51126; 1.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   TIGRFAMs; TIGR01414; autotrans_barl; 1.
DR   TIGRFAMs; TIGR02601; autotrns_rpt; 1.
DR   PROSITE; PS51208; AUTOTRANSPORTER; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Protease; Secreted; Serine protease; Signal; Zymogen.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000250"
FT   CHAIN           28..645
FT                   /note="Extracellular serine protease"
FT                   /id="PRO_0000027146"
FT   PROPEP          646..1045
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000027147"
FT   DOMAIN          49..396
FT                   /note="Peptidase S8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT   DOMAIN          769..1045
FT                   /note="Autotransporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00556"
FT   ACT_SITE        76
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        112
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        341
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
SQ   SEQUENCE   1045 AA;  112729 MW;  A71E938506EEA39A CRC64;
     MILNKKLKLA YCVFLGCYGL SLHSSLAAYR EPGQLGSPDS WKNAEFNRQW GLEAISAEFA
     YARAYTGKGV TIGVIDDAIL SHPEFAGKLT RLDNGSYNFS YDKQDNMSFG THGTHVAGIA
     AAKRDGSGMH GVAYDADIIG TKLNDYGNRN GREELIQSAA RVINNSWGIR PDIRRDAKGD
     IIWLPNGRPD YVAWVKTDVI NEVMRNKSNL EWGSEQPVPT GGHSAMATLL RAAKHGKLIV
     FSAGNYNNYN IPEAQKSLPY AFPEVLNNYL IVTNLSNNDK LSVSSTSCGH TASFLACQPG
     SSIYSSVGEL VSNTGGAVNR EAYNKGELTV KPDYGNMSGT SMAPDVTGFA AVLMQRFPYM
     SAAQISAVIK TTATDLGEVG IDHLFGWGRV NLRDAINGPK MFITQEDIPQ EFYVPGSYSE
     KQFVVNIPGL GNIVEAGTPV ERRCTSGECD FDSWSNDIRG HGGLTKTGAG TLAVLGNNTY
     SGDTWVKQGV LAYNGSVASN VYIENSGTVA GDRTVGAFRA VRGCEHGDAG NGYGTLHVLL
     DAVFDRGSQY NVELADKGRS DKLAARRAFL NGGSMNVSLD RSQKLMSQNE AELLVGNNYT
     ILTTLDGVTG RFDNANPSYP FVKVALDYRG NDTGLGITKT DATFDSLAST ENDKEVARAV
     ETLNATEPVT ETAKRSVSIP ASEEANLQQS DAGAAQAVNE EASIVAGHPI YESFLGFTTA
     RELQQATRQL SGQIHADMAS AQINESRYLR DTATERLRQA DGRRTASDIK ADDNGAWAKL
     LGNWGHASGN DNATGYQTST YGVLLGLDSE LFDDGRLGVM TGYTRTSLVG GLQSVVHSDT
     THLGLYGDKR FGALALPAGG TYTWHRIDTS RSVNYGAQAD REKARYNART GQLFIESGYD
     WSNDVVNLEP FANLAYTHYR NEGINEQGGA AALRGDKQSQ SATASTLGLR ADTQWQTDSV
     AIALPGELGW QHQYGKLERK TQLMFKRSDV AFDVNSVPVS RDGAILKAGV DVSINKNVVL
     SLGYGGQLSS NHQDNSVNAG LTWRF