ID   PRTY_THUTH              Reviewed;          34 AA.
AC   P02321;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Protamine-Y1/Y2;
DE   AltName: Full=Thynnin-Y1/Y2;
OS   Thunnus thynnus (Atlantic bluefin tuna) (Scomber thynnus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Pelagiaria; Scombriformes; Scombridae; Thunnus.
OX   NCBI_TaxID=8237;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=4559647;
RA   Bretzel G.;
RT   "Thynnin, the protamine of tuna fish. Complete amino acid sequence of
RT   thynnin Y2. XI. Report on the structure of protamines described by E.
RT   Waldschmidt-Leitz et al.";
RL   Hoppe-Seyler's Z. Physiol. Chem. 353:933-943(1972).
RN   [2]
RP   PROTEIN SEQUENCE OF THERMOLYSIN PEPTIDES.
RX   PubMed=5027704;
RA   Bretzel G.;
RT   "Thynnin, the protamine of tuna fish: isolation and characterisation of the
RT   peptides obtained from thynnin Y2 by the action of thermolysin. X.
RT   Communications on the structure of protamines from the studies of
RT   Waldschmidt-Leitz and coworkers.";
RL   Hoppe-Seyler's Z. Physiol. Chem. 353:209-216(1972).
CC   -!- FUNCTION: Protamines substitute for histones in the chromatin of sperm
CC       during the haploid phase of spermatogenesis. They compact sperm DNA
CC       into a highly condensed, stable and inactive complex.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC   -!- TISSUE SPECIFICITY: Testis.
CC   -!- MISCELLANEOUS: The protamine-Y2 sequence is shown.
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DR   PIR; A02663; TYTUY2.
DR   AlphaFoldDB; P02321; -.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Chromosome; Developmental protein; Differentiation;
KW   Direct protein sequencing; DNA condensation; DNA-binding; Nucleosome core;
KW   Nucleus; Spermatogenesis.
FT   PEPTIDE         1..34
FT                   /note="Protamine-Y1/Y2"
FT                   /evidence="ECO:0000269|PubMed:5027704"
FT                   /id="PRO_0000044852"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         6
FT                   /note="Q -> E (in protamine-Y1)"
SQ   SEQUENCE   34 AA;  4569 MW;  EEF72CFE31D1F0DE CRC64;
     PRRRRQASRP VRRRRRYRRS TAARRRRRVV RRRR