ID   PRTZ2_SCYCA             Reviewed;          45 AA.
AC   P06841;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Protamine Z2;
DE   AltName: Full=Scylliorhinine Z2;
OS   Scyliorhinus canicula (Small-spotted catshark) (Squalus canicula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC   Scyliorhinus.
OX   NCBI_TaxID=7830;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RX   PubMed=3769930; DOI=10.1111/j.1432-1033.1986.tb09972.x;
RA   Berlot-Picard F., Vodjdani G., Doly J.;
RT   "Nucleotide sequence of a cDNA clone encoding Scylliorhinus caniculus
RT   protamine Z2.";
RL   Eur. J. Biochem. 160:305-310(1986).
RN   [2]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Testis;
RA   Martinage A., Gusse M., Belaiche D., Sautiere P., Chevaillier P.;
RT   "Amino acid sequence of a cysteine-rich, arginine-rich sperm protamine of
RT   the dog-fish Scylliorhinus caniculus.";
RL   Biochim. Biophys. Acta 831:172-178(1985).
RN   [3]
RP   PROTEIN SEQUENCE OF 1-5.
RX   PubMed=6615852; DOI=10.1016/0167-4838(83)90031-6;
RA   Gusse M., Sautiere P., Chauviere M., Chevaillier P.;
RT   "Extraction, purification and characterization of the sperm protamines of
RT   the dog-fish Scylliorhinus caniculus.";
RL   Biochim. Biophys. Acta 748:93-98(1983).
CC   -!- FUNCTION: Protamines substitute for histones in the chromatin of sperm
CC       during the haploid phase of spermatogenesis. They compact sperm DNA
CC       into a highly condensed, stable and inactive complex.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC   -!- TISSUE SPECIFICITY: Testis.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X04517; CAA28202.1; -; mRNA.
DR   PIR; A18865; A18865.
DR   AlphaFoldDB; P06841; -.
DR   SMR; P06841; -.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Chromosome; Developmental protein; Differentiation;
KW   Direct protein sequencing; DNA condensation; DNA-binding; Nucleosome core;
KW   Nucleus; Spermatogenesis.
FT   CHAIN           1..45
FT                   /note="Protamine Z2"
FT                   /id="PRO_0000106630"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        45
FT                   /note="P -> PR (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   45 AA;  5579 MW;  3FA948591F41C697 CRC64;
     MKCGRKRRRR RRHACKRKKR ACKQRSSTIV RAHLVHRRRA ARRCP