ID   PRTZ_CLUHA              Reviewed;          31 AA.
AC   P69010; P02336;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Protamine-Z;
DE   AltName: Full=Clupeine-Z;
OS   Clupea harengus (Atlantic herring).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Clupei; Clupeiformes; Clupeoidei;
OC   Clupeidae; Clupea.
OX   NCBI_TaxID=7950;
RN   [1]
RP   PROTEIN SEQUENCE.
RA   Chang W.J., Nukushina M., Ishii S., Nakahara C., Ando T.;
RL   Submitted (AUG-1970) to the PIR data bank.
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
RX   PubMed=1772633; DOI=10.1107/s010876819100842x;
RA   Balschmidt P., Hansen F.B., Dodson E., Dodson G., Korber F.;
RT   "Structure of porcine insulin cocrystallized with clupeine Z.";
RL   Acta Crystallogr. B 47:975-986(1991).
CC   -!- FUNCTION: Protamines substitute for histones in the chromatin of sperm
CC       during the haploid phase of spermatogenesis. They compact sperm DNA
CC       into a highly condensed, stable and inactive complex.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC   -!- TISSUE SPECIFICITY: Testis.
CC   -!- MISCELLANEOUS: Clupeine Z is probably the result of a crossover between
CC       the genes for clupeines YI and YII.
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DR   PIR; A37576; CLHRZA.
DR   PDB; 7INS; X-ray; 2.00 A; G=-.
DR   PDBsum; 7INS; -.
DR   AlphaFoldDB; P69010; -.
DR   EvolutionaryTrace; P69010; -.
DR   Proteomes; UP000515152; Genome assembly.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   3D-structure; Chromosome; Developmental protein; Differentiation;
KW   Direct protein sequencing; DNA condensation; DNA-binding; Nucleosome core;
KW   Nucleus; Reference proteome; Spermatogenesis.
FT   PEPTIDE         1..31
FT                   /note="Protamine-Z"
FT                   /id="PRO_0000044827"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   31 AA;  4165 MW;  092CCBF7F3AFC050 CRC64;
     ARRRRSRRAS RPVRRRRPRR VSRRRRARRR R