PRTZ_THUTH
ID PRTZ_THUTH Reviewed; 34 AA.
AC P02322;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 25-MAY-2022, entry version 61.
DE RecName: Full=Protamine-Z1/Z2;
DE AltName: Full=Thynnin-Z1/Z2;
OS Thunnus thynnus (Atlantic bluefin tuna) (Scomber thynnus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Pelagiaria; Scombriformes; Scombridae; Thunnus.
OX NCBI_TaxID=8237;
RN [1]
RP PROTEIN SEQUENCE (Z1).
RX PubMed=4803475;
RA Bretzel G.;
RT "Thynnin, the protamine of the tuna fish: amino acid sequence of thynnin
RT Z1. XIII. Communication on the structure of protamines from the studies of
RT E. Waldschmidt-Leitz and coworkers.";
RL Hoppe-Seyler's Z. Physiol. Chem. 354:312-320(1973).
RN [2]
RP PROTEIN SEQUENCE (Z2).
RX PubMed=4609881;
RA Bretzel G.;
RT "Thynnin, the protamine of the tuna fish: the amino acid sequence of
RT thynnin Z2. XIV. Communication on the structure of the protamines described
RT by E. Waldschmidt-Leitz et al.";
RL Hoppe-Seyler's Z. Physiol. Chem. 354:543-549(1973).
CC -!- FUNCTION: Protamines substitute for histones in the chromatin of sperm
CC during the haploid phase of spermatogenesis. They compact sperm DNA
CC into a highly condensed, stable and inactive complex.
CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC -!- TISSUE SPECIFICITY: Testis.
CC -!- MISCELLANEOUS: The protamine-Z1 sequence is shown.
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DR PIR; A91656; TYTUZ1.
DR PIR; A91657; A91657.
DR AlphaFoldDB; P02322; -.
DR IntAct; P02322; 1.
DR MINT; P02322; -.
DR iPTMnet; P02322; -.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Chromosome; Developmental protein; Differentiation;
KW Direct protein sequencing; DNA condensation; DNA-binding; Nucleosome core;
KW Nucleus; Spermatogenesis.
FT PEPTIDE 1..34
FT /note="Protamine-Z1/Z2"
FT /id="PRO_0000044853"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 22
FT /note="V -> A (in protamine-Z2)"
SQ SEQUENCE 34 AA; 4641 MW; EEF72CED0158C3DE CRC64;
PRRRRRSSRP VRRRRRYRRS TVARRRRRVV RRRR
