ID   PRT_ANTGR               Reviewed;         132 AA.
AC   P17502;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Protamine;
OS   Anthonomus grandis (Mexican cotton boll weevil) (Anthonomus thurberiae).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Curculionidae; Curculioninae; Anthonomini; Anthonomus.
OX   NCBI_TaxID=7044;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RX   PubMed=2362819; DOI=10.1093/nar/18.12.3646;
RA   Trewitt P.M., Heilmann L.J., Kumaran A.K.;
RT   "Boll weevil testis-specific cDNA.";
RL   Nucleic Acids Res. 18:3646-3646(1990).
CC   -!- FUNCTION: Protamines substitute for histones in the chromatin of sperm
CC       during the haploid phase of spermatogenesis. They compact sperm DNA
CC       into a highly condensed, stable and inactive complex.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC   -!- TISSUE SPECIFICITY: Testis.
CC   -!- SIMILARITY: Belongs to the UPF0771 family. {ECO:0000305}.
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DR   EMBL; X52058; CAA36282.1; -; mRNA.
DR   PIR; S10305; S10305.
DR   AlphaFoldDB; P17502; -.
DR   SMR; P17502; -.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   GO; GO:0035092; P:sperm DNA condensation; IEA:InterPro.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR024460; Protamine-like.
DR   Pfam; PF06382; Protamine_like; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; Developmental protein; Differentiation; DNA condensation;
KW   DNA-binding; Nucleosome core; Nucleus; Spermatogenesis.
FT   CHAIN           1..132
FT                   /note="Protamine"
FT                   /id="PRO_0000106644"
FT   REGION          17..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          96..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..45
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..115
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   132 AA;  16280 MW;  8AC65334FCECE00D CRC64;
     MGLGFKCRHI PPSVYCGGKK RRRRRSKRRR SRCGRSRRRK SCRGGRKTNN PFLNYLRVFR
     KKHCGWPQCR IAIEGAKCWC KMSGRDRKKY YNQACSMLKK RGRRRRRRSC RRRRRSCRRR
     RRRRRSCNTC PK