ID   PRU1_PRUAV              Reviewed;         160 AA.
AC   O24248;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Major allergen Pru av 1;
DE   AltName: Full=Allergen Pru a 1;
DE   AltName: Allergen=Pru av 1;
GN   Name=PRUA1;
OS   Prunus avium (Cherry) (Cerasus avium).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Amygdaleae; Prunus.
OX   NCBI_TaxID=42229;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9393965; DOI=10.1016/s0161-5890(97)00072-2;
RA   Scheurer S., Metzner K., Haustein D., Vieths S.;
RT   "Molecular cloning, expression and characterization of Pru a 1, the major
RT   cherry allergen.";
RL   Mol. Immunol. 34:619-629(1997).
RN   [2]
RP   STRUCTURE BY NMR.
RX   PubMed=11287426; DOI=10.1074/jbc.m101657200;
RA   Neudecker P., Schweimer K., Nerkamp J., Scheurer S., Vieths S., Sticht H.,
RA   Rosch P.;
RT   "Allergic cross-reactivity made visible. Solution structure of the major
RT   cherry allergen Pru av 1.";
RL   J. Biol. Chem. 276:22756-22763(2001).
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE and
CC       induces a strong histamine release.
CC   -!- SIMILARITY: Belongs to the BetVI family. {ECO:0000305}.
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DR   EMBL; U66076; AAC02632.1; -; mRNA.
DR   PDB; 1E09; NMR; -; A=2-160.
DR   PDB; 1H2O; NMR; -; A=2-160.
DR   PDBsum; 1E09; -.
DR   PDBsum; 1H2O; -.
DR   AlphaFoldDB; O24248; -.
DR   BMRB; O24248; -.
DR   SMR; O24248; -.
DR   Allergome; 1316; Pru av 1.0101.
DR   Allergome; 597; Pru av 1.
DR   EnsemblPlants; Pav_sc0000174.1_g1420.1.mk:mrna; Pav_sc0000174.1_g1420.1.mk:mrna; Pav_sc0000174.1_g1420.1.mk.
DR   Gramene; Pav_sc0000174.1_g1420.1.mk:mrna; Pav_sc0000174.1_g1420.1.mk:mrna; Pav_sc0000174.1_g1420.1.mk.
DR   EvolutionaryTrace; O24248; -.
DR   Proteomes; UP000515124; Unplaced.
DR   GO; GO:0010427; F:abscisic acid binding; IEA:InterPro.
DR   GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:InterPro.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0009738; P:abscisic acid-activated signaling pathway; IEA:InterPro.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.530.20; -; 1.
DR   InterPro; IPR000916; Bet_v_I/MLP.
DR   InterPro; IPR024949; Bet_v_I_allergen.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   Pfam; PF00407; Bet_v_1; 1.
DR   PRINTS; PR00634; BETALLERGEN.
DR   PROSITE; PS00451; PATHOGENESIS_BETVI; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Allergen; Pathogenesis-related protein; Plant defense;
KW   Reference proteome.
FT   CHAIN           1..160
FT                   /note="Major allergen Pru av 1"
FT                   /id="PRO_0000154202"
FT   STRAND          3..14
FT                   /evidence="ECO:0007829|PDB:1E09"
FT   HELIX           16..23
FT                   /evidence="ECO:0007829|PDB:1E09"
FT   TURN            24..26
FT                   /evidence="ECO:0007829|PDB:1E09"
FT   HELIX           27..34
FT                   /evidence="ECO:0007829|PDB:1E09"
FT   TURN            36..38
FT                   /evidence="ECO:0007829|PDB:1E09"
FT   STRAND          39..50
FT                   /evidence="ECO:0007829|PDB:1E09"
FT   STRAND          54..59
FT                   /evidence="ECO:0007829|PDB:1E09"
FT   STRAND          62..64
FT                   /evidence="ECO:0007829|PDB:1E09"
FT   STRAND          66..75
FT                   /evidence="ECO:0007829|PDB:1E09"
FT   TURN            77..79
FT                   /evidence="ECO:0007829|PDB:1E09"
FT   STRAND          81..86
FT                   /evidence="ECO:0007829|PDB:1E09"
FT   TURN            90..92
FT                   /evidence="ECO:0007829|PDB:1E09"
FT   HELIX           93..95
FT                   /evidence="ECO:0007829|PDB:1E09"
FT   STRAND          96..105
FT                   /evidence="ECO:0007829|PDB:1E09"
FT   STRAND          111..123
FT                   /evidence="ECO:0007829|PDB:1E09"
FT   HELIX           131..154
FT                   /evidence="ECO:0007829|PDB:1E09"
FT   TURN            156..159
FT                   /evidence="ECO:0007829|PDB:1H2O"
SQ   SEQUENCE   160 AA;  17660 MW;  4CED0AF76310A893 CRC64;
     MGVFTYESEF TSEIPPPRLF KAFVLDADNL VPKIAPQAIK HSEILEGDGG PGTIKKITFG
     EGSQYGYVKH KIDSIDKENY SYSYTLIEGD ALGDTLEKIS YETKLVASPS GGSIIKSTSH
     YHTKGNVEIK EEHVKAGKEK ASNLFKLIET YLKGHPDAYN