PRUN2_MOUSE
ID PRUN2_MOUSE Reviewed; 3084 AA.
AC Q52KR3; Q501M3; Q6A079; Q8BW65; Q8BYM6; Q9D217;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Protein prune homolog 2;
DE AltName: Full=BNIP2 motif-containing molecule at the C-terminal region 1;
GN Name=Prune2; Synonyms=Bmcc1, Kiaa0367;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Fetal brain;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2724-3084 (ISOFORM 6).
RC STRAIN=C57BL/6J, and NOD;
RC TISSUE=Bone marrow, Hypothalamus, Oviduct, and Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1874-3084 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain, and Embryonic stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP INDUCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=16288218; DOI=10.1038/sj.onc.1209225;
RA Machida T., Fujita T., Ooo M.L., Ohira M., Isogai E., Mihara M., Hirato J.,
RA Tomotsune D., Hirata T., Fujimori M., Adachi W., Nakagawara A.;
RT "Increased expression of proapoptotic BMCC1, a novel gene with the BNIP2
RT and Cdc42GAP homology (BCH) domain, is associated with favorable prognosis
RT in human neuroblastomas.";
RL Oncogene 25:1931-1942(2006).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play an important role in regulating differentiation,
CC survival and aggressiveness of the tumor cells. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q52KR3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q52KR3-2; Sequence=VSP_022905, VSP_022906, VSP_022908;
CC Name=3;
CC IsoId=Q52KR3-3; Sequence=VSP_022905, VSP_022908;
CC Name=4;
CC IsoId=Q52KR3-4; Sequence=VSP_022905, VSP_039358;
CC Name=5;
CC IsoId=Q52KR3-5; Sequence=VSP_039356, VSP_039357;
CC Name=6;
CC IsoId=Q52KR3-6; Sequence=VSP_039358;
CC -!- DEVELOPMENTAL STAGE: In the embryo specifically expressed in neural
CC tube and neural crest-related tissues. At 10.5 dpc, highly expressed in
CC neural tube and pharyngeal arches which are derived from neural crest.
CC Expression is more restricted in the later stages of development. At
CC 12.5 dpc, expressed in spinal cord, hindbrain, midbrain, forebrain and
CC dorsal root ganglia (DRG). Although the expression at 14.5 dpc is
CC similar to those in 12.5 dpc, the regions expressing in hindbrain,
CC spinal cord and forebrain at 14.5 dpc are more dorsally restricted than
CC at 12.5 dpc. {ECO:0000269|PubMed:16288218}.
CC -!- INDUCTION: Down-regulated after nerve growth factor (NGF)-induced
CC differentiation, and up-regulated during the NGF-depletion-induced
CC apoptosis. {ECO:0000269|PubMed:16288218}.
CC -!- SIMILARITY: Belongs to the PPase class C family. Prune subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH94224.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAD32217.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAE41506.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK172939; BAD32217.1; ALT_INIT; mRNA.
DR EMBL; AK020727; BAB32192.1; -; mRNA.
DR EMBL; AK038997; BAC30198.1; -; mRNA.
DR EMBL; AK054190; BAC35688.1; -; mRNA.
DR EMBL; AK165582; BAE38273.1; -; mRNA.
DR EMBL; AK170001; BAE41506.1; ALT_INIT; mRNA.
DR EMBL; AC126674; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC128703; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC147026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC094224; AAH94224.1; ALT_INIT; mRNA.
DR EMBL; BC095978; AAH95978.1; -; mRNA.
DR CCDS; CCDS50400.1; -. [Q52KR3-1]
DR RefSeq; NP_851993.3; NM_181348.4. [Q52KR3-1]
DR RefSeq; XP_006527217.1; XM_006527154.2. [Q52KR3-6]
DR SMR; Q52KR3; -.
DR BioGRID; 237273; 10.
DR IntAct; Q52KR3; 1.
DR STRING; 10090.ENSMUSP00000084977; -.
DR iPTMnet; Q52KR3; -.
DR PhosphoSitePlus; Q52KR3; -.
DR jPOST; Q52KR3; -.
DR MaxQB; Q52KR3; -.
DR PaxDb; Q52KR3; -.
DR PeptideAtlas; Q52KR3; -.
DR PRIDE; Q52KR3; -.
DR ProteomicsDB; 291683; -. [Q52KR3-1]
DR ProteomicsDB; 291684; -. [Q52KR3-2]
DR ProteomicsDB; 291685; -. [Q52KR3-3]
DR ProteomicsDB; 291686; -. [Q52KR3-4]
DR ProteomicsDB; 291687; -. [Q52KR3-5]
DR ProteomicsDB; 291688; -. [Q52KR3-6]
DR Antibodypedia; 27288; 114 antibodies from 28 providers.
DR Ensembl; ENSMUST00000087689; ENSMUSP00000084977; ENSMUSG00000039126. [Q52KR3-1]
DR Ensembl; ENSMUST00000223920; ENSMUSP00000153418; ENSMUSG00000039126. [Q52KR3-4]
DR Ensembl; ENSMUST00000225351; ENSMUSP00000153135; ENSMUSG00000039126. [Q52KR3-3]
DR GeneID; 353211; -.
DR KEGG; mmu:353211; -.
DR UCSC; uc008gxf.2; mouse. [Q52KR3-4]
DR UCSC; uc008gxg.2; mouse. [Q52KR3-1]
DR CTD; 158471; -.
DR MGI; MGI:1925004; Prune2.
DR VEuPathDB; HostDB:ENSMUSG00000039126; -.
DR eggNOG; KOG4129; Eukaryota.
DR GeneTree; ENSGT00940000154422; -.
DR HOGENOM; CLU_227259_0_0_1; -.
DR InParanoid; Q52KR3; -.
DR OMA; WMDAKQP; -.
DR OrthoDB; 1545660at2759; -.
DR PhylomeDB; Q52KR3; -.
DR TreeFam; TF323914; -.
DR BioGRID-ORCS; 353211; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Prune2; mouse.
DR PRO; PR:Q52KR3; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q52KR3; protein.
DR Bgee; ENSMUSG00000039126; Expressed in facial nucleus and 185 other tissues.
DR ExpressionAtlas; Q52KR3; baseline and differential.
DR Genevisible; Q52KR3; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0016462; F:pyrophosphatase activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IBA:GO_Central.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.10.310.20; -; 1.
DR Gene3D; 3.40.525.10; -; 1.
DR InterPro; IPR022181; Bcl2-/adenovirus-E1B.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR038763; DHH_sf.
DR InterPro; IPR004097; DHHA2.
DR InterPro; IPR038222; DHHA2_dom_sf.
DR Pfam; PF12496; BNIP2; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF02833; DHHA2; 1.
DR SMART; SM01131; DHHA2; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF52087; SSF52087; 1.
DR SUPFAM; SSF64182; SSF64182; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Apoptosis; Cytoplasm;
KW Reference proteome.
FT CHAIN 1..3084
FT /note="Protein prune homolog 2"
FT /id="PRO_0000274881"
FT DOMAIN 2879..3040
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT REGION 394..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 500..536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 672..733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 811..837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 861..907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 947..1080
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1224..1316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1338..1395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1502..1543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1600..1652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1776..1799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1836..1886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1961..1980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2071..2196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2410..2782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2797..2816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2825..2859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 109..111
FT /note="DHH motif"
FT /evidence="ECO:0000250"
FT COMPBIAS 430..444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..529
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 811..834
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 865..895
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 947..974
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 981..1001
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1007..1022
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1033..1073
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1266..1298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1361..1387
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1522..1543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1618..1635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1836..1871
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1964..1980
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2075..2090
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2091..2105
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2117..2135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2154..2191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2413..2439
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2450..2471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2487..2523
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2536..2554
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2564..2619
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2673..2687
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2703..2718
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2719..2754
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2836..2851
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q8WUY3"
FT VAR_SEQ 1..2749
FT /note="Missing (in isoform 2, isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:15368895,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:16141072"
FT /id="VSP_022905"
FT VAR_SEQ 252..263
FT /note="DYLLHGNITSDL -> VRKSGHSPLARG (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_039356"
FT VAR_SEQ 264..3084
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_039357"
FT VAR_SEQ 2893
FT /note="G -> GGDS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15368895"
FT /id="VSP_022906"
FT VAR_SEQ 3034..3075
FT /note="KYDEEKSFKRSVRLDEELREASEAAKTSCLYNDPEMSSMEKD -> N (in
FT isoform 4 and isoform 6)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_039358"
FT VAR_SEQ 3035..3046
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15368895,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_022908"
FT CONFLICT 132
FT /note="E -> K (in Ref. 2; BAB32192)"
FT /evidence="ECO:0000305"
FT CONFLICT 146
FT /note="S -> F (in Ref. 2; BAB32192)"
FT /evidence="ECO:0000305"
FT CONFLICT 156
FT /note="A -> V (in Ref. 2; BAB32192)"
FT /evidence="ECO:0000305"
FT CONFLICT 2724
FT /note="M -> L (in Ref. 2; BAE41506)"
FT /evidence="ECO:0000305"
FT CONFLICT 2740
FT /note="L -> P (in Ref. 2; BAE41506)"
FT /evidence="ECO:0000305"
FT CONFLICT 2939
FT /note="A -> V (in Ref. 4; AAH95978)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 3084 AA; 339516 MW; FAF4C3D4DFC6893A CRC64;
MEEFLQRAKS KLDRSKQLEQ VHAVIGPKSC DLDSLISAFT YAYFLDKVSP PGVLCLPVLN
IPRTEFNYFT ETRFILEELN IPESFHIFRD EINLHQLNDE GKLSITLVGS HVLGSEDRTL
ESAVVRVINP GEQSDGELGF PETSSSLVLK ELLREAPELI TQQLAHLLRG SILFTWMSMD
PELPEKQEEI LSILEEQFPN LPPRDDIINV LQESQLSAQG LSLEQTMLKD LKELSDGEIK
VAISTVNMTL EDYLLHGNIT SDLKAFTDKF GFDVLILISS FTWEEQQRQQ IAVYSQNLEL
CSQICCELEE SQNPCLELEP FECGCDEILV YQQEDPSVTS DQVFLLLKEV INRRCAEMVS
NSRTSSTEAV AGSAPLSQGS SGIMELYGSD IEPQPSSVNF IENPPELNDS NQAQADGNID
LVSPDSGLAT IRSSRSSKES SVFLSDDSPV GDGGAPHHSL LPGFDSYSPI PEGIVAEEHA
HSGEHSEHFD LFNFDSAPIA SEQSQPSSHS ADYSPEDDFP NSDSSEGNLS AGPKGLGEMG
INMSNYSSSS LLSEAGKDSL VEFDEEFIQR QESSGDNSER NLSLTCFAGE EPSSPERLKN
PGKMIPPTPM NSFVEISPSN EEPTPLYPED IIQNAIDTGH LGPPQARARC RSWWGGLEID
SKNVVDTWNA SEQESVFQSP EPWKDPKPEP VERRTSDSTF QPKSLEFSKS DPWESEFGQP
ELGNKEAQDQ KEESLQYQHL PTVRPHLTDA SPHGTNHLIE DFAALWHSGH SPTTMPEPWG
NPTDAGEAAV TMSFPTWGAF DKEEDNADTL KNTWNLHPTN NETPSGQEPS EWAMGQSGFS
FPAADLLDNP LIEVNKDAAP EIWGKNNSSK DTSLTSGSPT SDLGQTWNNS KLPGEDQNGL
VDPKATGKVY EKEGSWSLFE ESAKKRGADV LAPWEDSFLS YKCSDYSASN IGEDSVPSPL
DTNYSTSDSY TSPTYAGDEK EIANKPVDKD NGFEAKDAEF PAEGLEVLAT SSQQSQRNRI
GSGPGNLDMW ALPHTEDKPE GNDAHHPDSD ALKTEHAEDK NASMEDDVRE SSPSSYDDPS
MMRLYEANRQ LTLLHSNTNS RQAAPDSLDT WNRVTLEDTQ STATISDMDN DLDWDDCSGG
VAISGDGQAE GYIAANSEPE TRFSVKQLEP WGTEHQEANQ VDWDLSASAE PTGDPGPSEY
QTLNEKTGQL IANSIWDSVM GDKNMPSFRL PSPPNTVDME HGTWPSESPR HSNGKDSHML
EASRLSESGG LTSQPVNQDT WGDSQGDTAS SVTGLASPEH FAQSDPWTGH TYGQSESEIE
GLVASDCEHL DKEAALGSGV NGAPWAFGKK PRDQEFSSSD AFEHQDISSA SGKISSLSVT
SSPQSEEPGE ALEVEKEPFI LDSLAVQTET FTWDLQSKDT HEESLVDHRN LGEANTTLDR
INPMKNRPLS GMELEKTEAC TILKPERANG KLLYESSQDF GVWDGPMDSD VWDSHISYET
AMNSTGQRTE ERSLEALSPG NYDRDSLSSG CTHSSASSPD LHDSSVALSS WTYGPSAEHQ
KENHDDANKQ IHQESELFTT EAHVDVITEM KDFVENREDG FGKMSNQEDP QFPEIPNDPF
NSGPSSSSSS LGADKYSEYS HAYQEGDLTT KRQEENELGF LEIVEPEGTR IISTSSGSGN
DSGGDEELLE KELHLATVAQ SEAGACTSLH EPAFSATEHS KPEFSVFVGS LESIEKENKS
SPFSDSQQSS PGQWILSPLM QADTQDTCKE ETRAAETGTM DTTWHGSAST EAKNGDPDKL
EMLGFSADST EWWNAGAQEG RANAGMSAEE LSNSEGELEP TSPVFQNAGP WSLPIQNDSE
PVDTGSTNPF RGKLKSPVLD SHGDKSQEKL WNIQPKQLDS DANQLSQLVI LDQMKDKDSG
QQTAMSPAAG DLPAETLTQG QGRESMLSVW DRAEPALTHR DENGCVSTGV SPTECQQENQ
WEPEKPYLSH VTHSSTPTEN ALESNAPTQL MRKLDSDWNS PSPSEPQHNF VPDILHGNFE
EGGQLASASP DLWMDVKQPF SFKVDSENPD ILTHCDHDSN SQASSSPDVC HDSEGEQKME
KHTAVYLGLE VEPSEFSLTE PNMNDEPTWE PEQESLPHNS ELHSEHAMPL PPIDSQNDIN
NSSKPASSRS SPEPSDMRGD NNTSVTSMEE DTNPEVEAVD SVTIPGHFPR SEDADTFEAH
QEVSVEVDDS WVSKDLCPES QTGTRALLDC EQPFASESPA VLTDIFLTSD TCLDVSEAAL
DHSFSDASGL NTSTGTIDDM SKLTLSEGHP ETPVDGDAGK QDVCSSEASW GDFEYDAMGQ
NIDEELMREP EHFLYGGDLP SEESALKQSL TPYTPPFDLS YLTEPTGCTE TAQGAESPGD
ESLGSDAAEM LLSALPDHRE EDKAETNIRK PRYQMTVLHI HEDPEALSSP VGGTGSNNES
SPSNIDWEIE TDNSDSPAGG DMKPPNGKEI LELEEDEKVI PTKGPKQTEL EYKEEKQPEQ
SEDHQVLAVD YILVSHEKDS PLKPEAREAR ENIPELEQLS IGSRETGLPE TQLSGTPDTC
QSEFLNDVKV HSAERMSSSS NHESASLENP AQDQSWMVLS HSEVGDPPTE TRDSGPESPG
RTPEPFLSLS LDKGPKSQVL ERNKPLNSLA LEEVAGLSSQ SRNIERQGQA GLDAVPTQAA
THDNEWEMLS PQLSRKNRNP PQEMEEETQC PEPGPRKPRL KGPPSEDEGM DIHFEEGVLS
PSAADMRPEP PNSLDLNGSH PRRIKLTAPN INLSLDQSEG SILSDDNLDS PDEIDINVDE
LDTPDEADSF EYTNHEDPTA NKSSGQESES IPEYTAEEER EDNRLWRTVV IGEQEQRIDM
KVIEPYRRVI SHGGYYGDGL NAIIVFAACF LPDSSRADYH YVMENLFLYV ISTLELMVAE
DYMIVYLNGA TPRRKMPGLG WMKKCYQMID RRLRKNLKSF IIVHPSWFIR TILAVTRPFI
SSKFSSKIKY VTSLSELSGL IPMDCIHIPE SIIKYDEEKS FKRSVRLDEE LREASEAAKT
SCLYNDPEMS SMEKDIDMKL KEKP
