ID   PRUN2_PONAB             Reviewed;         323 AA.
AC   Q5R4Q8;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Protein prune homolog 2;
DE   AltName: Full=BNIP2 motif-containing molecule at the C-terminal region 1;
GN   Name=PRUNE2; Synonyms=BMCC1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play an important role in regulating differentiation,
CC       survival and aggressiveness of the tumor cells. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; CR861187; CAH93258.1; -; mRNA.
DR   RefSeq; NP_001126916.1; NM_001133444.1.
DR   AlphaFoldDB; Q5R4Q8; -.
DR   STRING; 9601.ENSPPYP00000021627; -.
DR   GeneID; 100173933; -.
DR   KEGG; pon:100173933; -.
DR   CTD; 158471; -.
DR   eggNOG; KOG3308; Eukaryota.
DR   InParanoid; Q5R4Q8; -.
DR   OrthoDB; 1545660at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   CDD; cd00170; SEC14; 1.
DR   Gene3D; 3.40.525.10; -; 1.
DR   InterPro; IPR022181; Bcl2-/adenovirus-E1B.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   Pfam; PF12496; BNIP2; 1.
DR   Pfam; PF13716; CRAL_TRIO_2; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SUPFAM; SSF52087; SSF52087; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; Reference proteome.
FT   CHAIN           1..323
FT                   /note="Protein prune homolog 2"
FT                   /id="PRO_0000274882"
FT   DOMAIN          130..291
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT   REGION          1..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          79..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..56
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        79..94
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   323 AA;  36838 MW;  9079AE2D436AB4AE CRC64;
     MDIPFEEGVL SPSAADMRPE PPNSLDLNDT HPRRIKLTAP NINLSLDQSE GSILSDDNLD
     SPDEIDINVD ELDTPDEADS FEYAGHEDPT ANKDSGQESE SIPEYTAEEE REDNRLWRTV
     VIGEQEQRID MKVIEPYRRV ISHGGYYGDG LNAIIVFAAC FLPDSSRADY HYVMENLFLY
     VISTLELMVA EDYMIVYLNG ATPRRRMPGL GWMKKCYQMI DRRLRKNLKS FIIVHPSWFI
     RTILAATRPF ISSKFSSKIK YVNSLSELSG LIPMDCIHIP ESIIKLDEEL REASEAAKTS
     CLYNDPEMSS MEKDIDLKLK EKP