PRV2_DANRE
ID PRV2_DANRE Reviewed; 109 AA.
AC Q9I8V0; Q567L1;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Parvalbumin-2;
DE AltName: Full=Parvalbumin beta;
GN Name=pvalb2; Synonyms=pvalb, pvalbl;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11002340;
RX DOI=10.1002/1097-0177(2000)9999:9999<::aid-dvdy1043>3.3.co;2-9;
RA Xu Y., He J., Wang X., Lim T.M., Gong Z.;
RT "Asynchronous activation of 10 muscle-specific protein (MSP) genes during
RT zebrafish somitogenesis.";
RL Dev. Dyn. 219:201-215(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Larva;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In muscle, parvalbumin is thought to be involved in
CC relaxation after contraction. It binds two calcium ions (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the parvalbumin family. {ECO:0000305}.
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DR EMBL; AF180888; AAF78471.1; -; mRNA.
DR EMBL; BC093135; AAH93135.1; -; mRNA.
DR RefSeq; NP_571591.1; NM_131516.2.
DR AlphaFoldDB; Q9I8V0; -.
DR SMR; Q9I8V0; -.
DR STRING; 7955.ENSDARP00000115580; -.
DR PaxDb; Q9I8V0; -.
DR PRIDE; Q9I8V0; -.
DR Ensembl; ENSDART00000010144; ENSDARP00000020027; ENSDARG00000002768.
DR Ensembl; ENSDART00000143534; ENSDARP00000115580; ENSDARG00000002768.
DR Ensembl; ENSDART00000181742; ENSDARP00000149083; ENSDARG00000114085.
DR GeneID; 58028; -.
DR KEGG; dre:58028; -.
DR CTD; 58028; -.
DR ZFIN; ZDB-GENE-000322-4; pvalb2.
DR eggNOG; KOG0027; Eukaryota.
DR GeneTree; ENSGT00940000163144; -.
DR HOGENOM; CLU_157356_0_0_1; -.
DR InParanoid; Q9I8V0; -.
DR OMA; NHKQFFA; -.
DR OrthoDB; 1524081at2759; -.
DR PhylomeDB; Q9I8V0; -.
DR TreeFam; TF332342; -.
DR PRO; PR:Q9I8V0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 12.
DR Bgee; ENSDARG00000002768; Expressed in larva and 20 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR008080; Parvalbumin.
DR PANTHER; PTHR11653; PTHR11653; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 3: Inferred from homology;
KW Calcium; Metal-binding; Muscle protein; Reference proteome; Repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..109
FT /note="Parvalbumin-2"
FT /id="PRO_0000073605"
FT DOMAIN 39..74
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 78..109
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 52
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 54
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 56
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 58
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02621"
FT BINDING 60
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02621"
FT BINDING 63
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 91
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 93
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 95
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 97
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 102
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ SEQUENCE 109 AA; 11622 MW; BFD3F9F9A0FC59C0 CRC64;
MAFAGILKDE DVAAALKDCA AADSFNYKNF FAKVGLSAKS PDDIKKAFFV IDQDKSGFIE
EDELKLFLQN FSAGARALTD AETKAFLSAG DSDGDGKIGV DEFALLVKA
