ID   PRVA_TRISE              Reviewed;         109 AA.
AC   P30563;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Parvalbumin alpha;
OS   Triakis semifasciata (Leopard shark).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Triakidae;
OC   Triakis.
OX   NCBI_TaxID=30493;
RN   [1]
RP   X-RAY CRYSTALLOGRAPHY (1.54 ANGSTROMS).
RC   TISSUE=Muscle;
RX   PubMed=1542115; DOI=10.1016/0022-2836(92)90985-s;
RA   Roquet F., Declercq J.-P., Tinant B., Rambaud J., Parello J.;
RT   "Crystal structure of the unique parvalbumin component from muscle of the
RT   leopard shark (Triakis semifasciata). The first X-ray study of an alpha-
RT   parvalbumin.";
RL   J. Mol. Biol. 223:705-720(1992).
CC   -!- FUNCTION: In muscle, parvalbumin is thought to be involved in
CC       relaxation after contraction. It binds two calcium ions.
CC   -!- SIMILARITY: Belongs to the parvalbumin family. {ECO:0000305}.
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DR   PDB; 5PAL; X-ray; 1.54 A; A=1-109.
DR   PDB; 5ZGM; X-ray; 1.40 A; A/B=1-109.
DR   PDBsum; 5PAL; -.
DR   PDBsum; 5ZGM; -.
DR   AlphaFoldDB; P30563; -.
DR   SMR; P30563; -.
DR   EvolutionaryTrace; P30563; -.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR008080; Parvalbumin.
DR   PANTHER; PTHR11653; PTHR11653; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   SMART; SM00054; EFh; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   1: Evidence at protein level;
KW   3D-structure; Calcium; Metal-binding; Muscle protein; Repeat.
FT   CHAIN           1..109
FT                   /note="Parvalbumin alpha"
FT                   /id="PRO_0000073601"
FT   DOMAIN          38..73
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          77..109
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         51
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         53
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         55
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         62
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         90
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         92
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         94
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         96
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         101
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   HELIX           2..4
FT                   /evidence="ECO:0007829|PDB:5ZGM"
FT   HELIX           8..17
FT                   /evidence="ECO:0007829|PDB:5ZGM"
FT   HELIX           26..32
FT                   /evidence="ECO:0007829|PDB:5ZGM"
FT   HELIX           40..50
FT                   /evidence="ECO:0007829|PDB:5ZGM"
FT   STRAND          55..58
FT                   /evidence="ECO:0007829|PDB:5ZGM"
FT   HELIX           60..64
FT                   /evidence="ECO:0007829|PDB:5ZGM"
FT   HELIX           66..70
FT                   /evidence="ECO:0007829|PDB:5ZGM"
FT   HELIX           79..89
FT                   /evidence="ECO:0007829|PDB:5ZGM"
FT   STRAND          94..97
FT                   /evidence="ECO:0007829|PDB:5ZGM"
FT   HELIX           99..108
FT                   /evidence="ECO:0007829|PDB:5ZGM"
SQ   SEQUENCE   109 AA;  11931 MW;  AED1E240174CF80E CRC64;
     PMTKVLKADD INKAISAFKD PGTFDYKRFF HLVGLKGKTD AQVKEVFEIL DKDQSGFIEE
     EELKGVLKGF SAHGRDLNDT ETKALLAAGD SDHDGKIGAD EFAKMVAQA