PRVB1_ONCMY
ID PRVB1_ONCMY Reviewed; 108 AA.
AC P86431;
DT 09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT 09-FEB-2010, sequence version 1.
DT 03-AUG-2022, entry version 33.
DE RecName: Full=Parvalbumin beta 1 {ECO:0000250|UniProtKB:Q91482, ECO:0000303|Ref.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY, ALLERGEN, AND ACETYLATION AT
RP ALA-1.
RC TISSUE=Muscle {ECO:0000269|Ref.1};
RA Kostadinova M., Bublin M., Radauer C., Briza P., Breiteneder H.;
RT "Detection of parvalbumins in fish protein extracts and fish containing
RT products with scFv-antibodies.";
RL Submitted (DEC-2009) to UniProtKB.
CC -!- FUNCTION: In muscle, parvalbumin is thought to be involved in
CC relaxation after contraction. It binds two calcium ions.
CC {ECO:0000269|Ref.1}.
CC -!- MASS SPECTROMETRY: Mass=11781; Method=MALDI;
CC Evidence={ECO:0000269|Ref.1};
CC -!- ALLERGEN: Causes an allergic reaction in human. {ECO:0000269|Ref.1}.
CC -!- SIMILARITY: Belongs to the parvalbumin family. {ECO:0000255}.
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DR Allergome; 8150; Onc m 1.
DR Allergome; 9514; Onc m 1.0101.
DR GO; GO:0016528; C:sarcoplasm; IDA:AgBase.
DR GO; GO:0005509; F:calcium ion binding; IDA:AgBase.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR008080; Parvalbumin.
DR PANTHER; PTHR11653; PTHR11653; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 1: Evidence at protein level;
KW Acetylation; Allergen; Calcium; Direct protein sequencing; Metal-binding;
KW Muscle protein; Repeat.
FT CHAIN 1..108
FT /note="Parvalbumin beta 1"
FT /id="PRO_0000391421"
FT DOMAIN 38..73
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 77..108
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 51
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 53
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 55
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 57
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02621"
FT BINDING 59
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02621"
FT BINDING 62
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 90
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 92
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 94
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 96
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 101
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT MOD_RES 1
FT /note="N-acetylalanine"
FT /evidence="ECO:0000269|Ref.1"
FT UNSURE 5
FT /note="L or I"
FT /evidence="ECO:0000269|Ref.1"
FT UNSURE 11
FT /note="L or I"
FT /evidence="ECO:0000269|Ref.1"
FT UNSURE 15
FT /note="L or I"
FT /evidence="ECO:0000269|Ref.1"
FT UNSURE 33
FT /note="L or I"
FT /evidence="ECO:0000269|Ref.1"
FT UNSURE 50
FT /note="L or I"
FT /evidence="ECO:0000269|Ref.1"
FT UNSURE 58
FT /note="L or I"
FT /evidence="ECO:0000269|Ref.1"
FT UNSURE 63
FT /note="L or I"
FT /evidence="ECO:0000269|Ref.1"
FT UNSURE 65
FT /note="L or I"
FT /evidence="ECO:0000269|Ref.1"
FT UNSURE 67
FT /note="L or I"
FT /evidence="ECO:0000269|Ref.1"
FT UNSURE 77
FT /note="L or I"
FT /evidence="ECO:0000269|Ref.1"
FT UNSURE 86
FT /note="L or I"
FT /evidence="ECO:0000269|Ref.1"
FT UNSURE 97
FT /note="L or I"
FT /evidence="ECO:0000269|Ref.1"
FT UNSURE 99
FT /note="L or I"
FT /evidence="ECO:0000269|Ref.1"
FT UNSURE 105
FT /note="L or I"
FT /evidence="ECO:0000269|Ref.1"
SQ SEQUENCE 108 AA; 11800 MW; EB4D4F5CFA36F34B CRC64;
ACAHLCKEAD LKTALEACKA ADSFNFKTFF HTLGFASKXX DDVKKXXXVL DQDASGFLEV
EELKLFLQNF CPKXXXLTDA ETKAFLKAGD ADGDGMLGLD EFAVLVKQ
