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PRVB2_MERAP
ID   PRVB2_MERAP             Reviewed;         108 AA.
AC   P86750;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 1.
DT   03-AUG-2022, entry version 24.
DE   RecName: Full=Parvalbumin beta 2 {ECO:0000303|PubMed:20586483};
OS   Merluccius australis polylepis (Southern hake) (Gadus australis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Zeiogadaria; Gadariae; Gadiformes; Gadoidei; Merlucciidae; Merluccius.
OX   NCBI_TaxID=307685;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, AND ACETYLATION AT ALA-1.
RC   TISSUE=Muscle {ECO:0000269|PubMed:20586483};
RX   PubMed=20586483; DOI=10.1021/pr100163e;
RA   Carrera M., Canas B., Vazquez J., Gallardo J.M.;
RT   "Extensive de novo sequencing of new parvalbumin isoforms using a novel
RT   combination of bottom-up proteomics, accurate molecular mass measurement by
RT   FTICR-MS, and selected MS/MS ion monitoring.";
RL   J. Proteome Res. 9:4393-4406(2010).
CC   -!- FUNCTION: In muscle, parvalbumin is thought to be involved in
CC       relaxation after contraction. It binds two calcium ions (By
CC       similarity). {ECO:0000250|UniProtKB:P02622,
CC       ECO:0000250|UniProtKB:P02624}.
CC   -!- MASS SPECTROMETRY: Mass=11354.806; Mass_error=0.0164;
CC       Method=Electrospray; Evidence={ECO:0000269|PubMed:20586483};
CC   -!- MISCELLANEOUS: Is regarded as an important allergen.
CC       {ECO:0000250|UniProtKB:P02622, ECO:0000269|PubMed:20586483}.
CC   -!- MISCELLANEOUS: On the 2D-gel the determined pI of this protein is:
CC       4.14, its MW is: 11.55 kDa. {ECO:0000269|PubMed:20586483}.
CC   -!- SIMILARITY: Belongs to the parvalbumin family. {ECO:0000255}.
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DR   AlphaFoldDB; P86750; -.
DR   SMR; P86750; -.
DR   iPTMnet; P86750; -.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR008080; Parvalbumin.
DR   PANTHER; PTHR11653; PTHR11653; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   SMART; SM00054; EFh; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   1: Evidence at protein level;
KW   Acetylation; Allergen; Calcium; Direct protein sequencing; Metal-binding;
KW   Muscle protein; Repeat.
FT   CHAIN           1..108
FT                   /note="Parvalbumin beta 2"
FT                   /id="PRO_0000399410"
FT   DOMAIN          38..73
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          77..108
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         51
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P02621,
FT                   ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         53
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P02621,
FT                   ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         55
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P02621,
FT                   ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         57
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P02621"
FT   BINDING         59
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P02621"
FT   BINDING         62
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P02621,
FT                   ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         90
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P02621,
FT                   ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         92
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P02621,
FT                   ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         94
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P02621,
FT                   ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         96
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P02621"
FT   BINDING         101
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P02621,
FT                   ECO:0000255|PROSITE-ProRule:PRU00448"
FT   MOD_RES         1
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          5
FT                   /note="I or L"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          6
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          11
FT                   /note="I or L"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          15
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          16
FT                   /note="K or Q"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          27
FT                   /note="K or Q"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          32
FT                   /note="K or Q"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          35
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          38
FT                   /note="K or Q"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          43
FT                   /note="I or L"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          44
FT                   /note="K or Q"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          45
FT                   /note="K or Q"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          50
FT                   /note="I or L"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          52
FT                   /note="Q or K"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          54
FT                   /note="K or Q"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          58
FT                   /note="I or L"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          63
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          64
FT                   /note="K or Q"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          65
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          67
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          68
FT                   /note="Q or K"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          77
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          83
FT                   /note="K or Q"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          86
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          87
FT                   /note="K or Q"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          97
FT                   /note="I or L"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          105
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          107
FT                   /note="K or Q"
FT                   /evidence="ECO:0000269|PubMed:20586483"
SQ   SEQUENCE   108 AA;  11320 MW;  DBA2AE6C2F5A01B6 CRC64;
     AFSGILAEAD IAAALKACEA ADSFNYKAFF AKVGLSAKSA DDIKKAFFVI DQDKSGFIEE
     DELKLFLQVF SAGARALTDA ETKAFLKAGD SDGDGAIGVD EFAVLVKA
 
 
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