PRVB2_ONCMY
ID PRVB2_ONCMY Reviewed; 107 AA.
AC P86432;
DT 09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT 09-FEB-2010, sequence version 1.
DT 03-AUG-2022, entry version 25.
DE RecName: Full=Parvalbumin beta 2 {ECO:0000250|UniProtKB:Q91483, ECO:0000303|Ref.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY, ALLERGEN, AND ACETYLATION AT
RP SER-1.
RC TISSUE=Muscle {ECO:0000269|Ref.1};
RA Kostadinova M., Bublin M., Radauer C., Briza P., Breiteneder H.;
RT "Detection of parvalbumins in fish protein extracts and fish containing
RT products with scFv-antibodies.";
RL Submitted (DEC-2009) to UniProtKB.
CC -!- FUNCTION: In muscle, parvalbumin is thought to be involved in
CC relaxation after contraction. It binds two calcium ions.
CC {ECO:0000269|Ref.1}.
CC -!- MASS SPECTROMETRY: Mass=11232.5; Method=MALDI;
CC Evidence={ECO:0000269|Ref.1};
CC -!- ALLERGEN: Causes an allergic reaction in human. {ECO:0000269|Ref.1}.
CC -!- SIMILARITY: Belongs to the parvalbumin family. {ECO:0000255}.
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DR Allergome; 8150; Onc m 1.
DR Allergome; 9515; Onc m 1.0201.
DR GO; GO:0016528; C:sarcoplasm; IDA:AgBase.
DR GO; GO:0005509; F:calcium ion binding; IDA:AgBase.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR008080; Parvalbumin.
DR PANTHER; PTHR11653; PTHR11653; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 1: Evidence at protein level;
KW Acetylation; Allergen; Calcium; Direct protein sequencing; Metal-binding;
KW Muscle protein; Repeat.
FT CHAIN 1..107
FT /note="Parvalbumin beta 2"
FT /id="PRO_0000391422"
FT DOMAIN 37..72
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 89..107
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 50
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 52
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 54
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 56
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02621"
FT BINDING 58
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02621"
FT BINDING 61
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 89
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 91
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 93
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 95
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 100
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT MOD_RES 1
FT /note="N-acetylserine"
FT /evidence="ECO:0000269|Ref.1"
FT UNSURE 5
FT /note="L or I"
FT /evidence="ECO:0000269|Ref.1"
FT UNSURE 14
FT /note="L or I"
FT /evidence="ECO:0000269|Ref.1"
FT UNSURE 42
FT /note="L or I"
FT /evidence="ECO:0000269|Ref.1"
FT UNSURE 49
FT /note="L or I"
FT /evidence="ECO:0000269|Ref.1"
FT UNSURE 57
FT /note="L or I"
FT /evidence="ECO:0000269|Ref.1"
FT UNSURE 62
FT /note="L or I"
FT /evidence="ECO:0000269|Ref.1"
FT UNSURE 64
FT /note="L or I"
FT /evidence="ECO:0000269|Ref.1"
FT UNSURE 66
FT /note="L or I"
FT /evidence="ECO:0000269|Ref.1"
FT UNSURE 76
FT /note="L or I"
FT /evidence="ECO:0000269|Ref.1"
FT UNSURE 96
FT /note="L or I"
FT /evidence="ECO:0000269|Ref.1"
FT UNSURE 98
FT /note="L or I"
FT /evidence="ECO:0000269|Ref.1"
FT UNSURE 104
FT /note="L or I"
FT /evidence="ECO:0000269|Ref.1"
SQ SEQUENCE 107 AA; 11345 MW; 0B8BAA1331A2EC2F CRC64;
SFAGLNDADV AAALAACAAA DSFNHKAFFA KXXXXXXSPD DLKKXXXXLD QDKSGFLEED
ELKLFLQNFS ASARALTDAE TKXXXXAGDA DGDGMLGLDE FAVLVKQ
