PRVB3_MACMG
ID PRVB3_MACMG Reviewed; 74 AA.
AC P86740;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 1.
DT 03-AUG-2022, entry version 22.
DE RecName: Full=Parvalbumin beta 3 {ECO:0000303|PubMed:20586483};
DE Flags: Fragments;
OS Macruronus magellanicus (Patagonian grenadier) (Macruronus novaezelandiae
OS magellanicus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Zeiogadaria; Gadariae; Gadiformes; Gadoidei; Merlucciidae; Macruronus.
OX NCBI_TaxID=92050;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE.
RC TISSUE=Muscle {ECO:0000269|PubMed:20586483};
RX PubMed=20586483; DOI=10.1021/pr100163e;
RA Carrera M., Canas B., Vazquez J., Gallardo J.M.;
RT "Extensive de novo sequencing of new parvalbumin isoforms using a novel
RT combination of bottom-up proteomics, accurate molecular mass measurement by
RT FTICR-MS, and selected MS/MS ion monitoring.";
RL J. Proteome Res. 9:4393-4406(2010).
CC -!- FUNCTION: In muscle, parvalbumin is thought to be involved in
CC relaxation after contraction. It binds two calcium ions (By
CC similarity). {ECO:0000250|UniProtKB:P02622,
CC ECO:0000250|UniProtKB:P02624}.
CC -!- MISCELLANEOUS: Is regarded as an important allergen.
CC {ECO:0000250|UniProtKB:P02622, ECO:0000269|PubMed:20586483}.
CC -!- SIMILARITY: Belongs to the parvalbumin family. {ECO:0000255}.
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DR AlphaFoldDB; P86740; -.
DR SMR; P86740; -.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR008080; Parvalbumin.
DR PANTHER; PTHR11653; PTHR11653; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 1: Evidence at protein level;
KW Allergen; Calcium; Direct protein sequencing; Metal-binding;
KW Muscle protein; Repeat.
FT CHAIN <1..>74
FT /note="Parvalbumin beta 3"
FT /id="PRO_0000399401"
FT DOMAIN 4..39
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 43..>74
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 17
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 19
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 21
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 23
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02621"
FT BINDING 25
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02621"
FT BINDING 28
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 56
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 58
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 60
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 62
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 67
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT UNSURE 4
FT /note="K or Q"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 10
FT /note="K or Q"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 11
FT /note="K or Q"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 16
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 18
FT /note="Q or K"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 20
FT /note="K or Q"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 24
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 29
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 30
FT /note="K or Q"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 31
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 33
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 34
FT /note="Q or K"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 43
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 49
FT /note="K or Q"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 52
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 63
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 69
FT /note="Q or K"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 71
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 73
FT /note="K or Q"
FT /evidence="ECO:0000269|PubMed:20586483"
FT NON_CONS 4..5
FT /evidence="ECO:0000303|PubMed:20586483"
FT NON_TER 1
FT /evidence="ECO:0000303|PubMed:20586483"
FT NON_TER 74
FT /evidence="ECO:0000303|PubMed:20586483"
SQ SEQUENCE 74 AA; 8028 MW; 593C76134B7AD69A CRC64;
TFFKSNDDVK KAFFVIDQDK SGFIEEDELK LFLQNFSAGA RALTAGETKT FLAAGDSDGD
GMIGVDEFQA LVKA