PRVB3_MACNO
ID PRVB3_MACNO Reviewed; 83 AA.
AC P86742;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 1.
DT 03-AUG-2022, entry version 26.
DE RecName: Full=Parvalbumin beta 3 {ECO:0000303|PubMed:20586483};
DE Flags: Fragments;
OS Macruronus novaezelandiae (Blue grenadier) (Macruronus novaezelandiae
OS novaezelandiae).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Zeiogadaria; Gadariae; Gadiformes; Gadoidei; Merlucciidae; Macruronus.
OX NCBI_TaxID=248764;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE.
RC TISSUE=Muscle {ECO:0000269|PubMed:20586483};
RX PubMed=20586483; DOI=10.1021/pr100163e;
RA Carrera M., Canas B., Vazquez J., Gallardo J.M.;
RT "Extensive de novo sequencing of new parvalbumin isoforms using a novel
RT combination of bottom-up proteomics, accurate molecular mass measurement by
RT FTICR-MS, and selected MS/MS ion monitoring.";
RL J. Proteome Res. 9:4393-4406(2010).
CC -!- FUNCTION: In muscle, parvalbumin is thought to be involved in
CC relaxation after contraction. It binds two calcium ions (By
CC similarity). {ECO:0000250|UniProtKB:P02622,
CC ECO:0000250|UniProtKB:P02624}.
CC -!- MISCELLANEOUS: Is regarded as an important allergen.
CC {ECO:0000250|UniProtKB:P02622, ECO:0000269|PubMed:20586483}.
CC -!- MISCELLANEOUS: On the 2D-gel the determined pI of this protein is:
CC 3.75, its MW is: 11.35 kDa. {ECO:0000269|PubMed:20586483}.
CC -!- SIMILARITY: Belongs to the parvalbumin family. {ECO:0000255}.
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DR AlphaFoldDB; P86742; -.
DR SMR; P86742; -.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR008080; Parvalbumin.
DR PANTHER; PTHR11653; PTHR11653; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 1: Evidence at protein level;
KW Allergen; Calcium; Direct protein sequencing; Metal-binding;
KW Muscle protein; Repeat.
FT CHAIN <1..>83
FT /note="Parvalbumin beta 3"
FT /id="PRO_0000399404"
FT DOMAIN 13..48
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 52..83
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 26
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 28
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 30
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 32
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02621"
FT BINDING 34
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02621"
FT BINDING 37
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 65
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 67
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 69
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 71
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 76
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT UNSURE 5
FT /note="K or Q"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 9
FT /note="K or Q"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 10
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 13
FT /note="K or Q"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 19
FT /note="K or Q"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 20
FT /note="K or Q"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 25
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 27
FT /note="Q or K"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 29
FT /note="K or Q"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 33
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 38
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 39
FT /note="K or Q"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 40
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 42
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 43
FT /note="Q or K"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 52
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 58
FT /note="K or Q"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 61
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 72
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 78
FT /note="Q or K"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 80
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 82
FT /note="K or Q"
FT /evidence="ECO:0000269|PubMed:20586483"
FT NON_CONS 9..10
FT /evidence="ECO:0000303|PubMed:20586483"
FT NON_TER 1
FT /evidence="ECO:0000303|PubMed:20586483"
FT NON_TER 83
FT /evidence="ECO:0000303|PubMed:20586483"
SQ SEQUENCE 83 AA; 9051 MW; 266A9738C5892DE4 CRC64;
SFNYKTFFKL AAKSNDDVKK AFFVIDQDKS GFIEEDELKL FLQNFSAGAR ALTAGETKTF
LAAGDSDGDG MIGVDEFQAL VKA
