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PRVB3_MERPA
ID   PRVB3_MERPA             Reviewed;          95 AA.
AC   P86770;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 1.
DT   03-AUG-2022, entry version 28.
DE   RecName: Full=Parvalbumin beta 3 {ECO:0000303|PubMed:20586483};
DE   Flags: Fragments;
OS   Merluccius paradoxus (Deep-water Cape hake) (Merluccius capensis
OS   paradoxus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Zeiogadaria; Gadariae; Gadiformes; Gadoidei; Merlucciidae; Merluccius.
OX   NCBI_TaxID=89950;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, AND ACETYLATION AT ALA-1.
RC   TISSUE=Muscle {ECO:0000269|PubMed:20586483};
RX   PubMed=20586483; DOI=10.1021/pr100163e;
RA   Carrera M., Canas B., Vazquez J., Gallardo J.M.;
RT   "Extensive de novo sequencing of new parvalbumin isoforms using a novel
RT   combination of bottom-up proteomics, accurate molecular mass measurement by
RT   FTICR-MS, and selected MS/MS ion monitoring.";
RL   J. Proteome Res. 9:4393-4406(2010).
CC   -!- FUNCTION: In muscle, parvalbumin is thought to be involved in
CC       relaxation after contraction. It binds two calcium ions (By
CC       similarity). {ECO:0000250|UniProtKB:P02622,
CC       ECO:0000250|UniProtKB:P02624}.
CC   -!- MISCELLANEOUS: Is regarded as an important allergen.
CC       {ECO:0000250|UniProtKB:P02622, ECO:0000269|PubMed:20586483}.
CC   -!- MISCELLANEOUS: On the 2D-gel the determined pI of this protein is:
CC       3.79, its MW is: 11.32 kDa. {ECO:0000269|PubMed:20586483}.
CC   -!- SIMILARITY: Belongs to the parvalbumin family. {ECO:0000255}.
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DR   AlphaFoldDB; P86770; -.
DR   SMR; P86770; -.
DR   iPTMnet; P86770; -.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR008080; Parvalbumin.
DR   PANTHER; PTHR11653; PTHR11653; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   1: Evidence at protein level;
KW   Acetylation; Allergen; Calcium; Direct protein sequencing; Metal-binding;
KW   Muscle protein; Repeat.
FT   CHAIN           1..>95
FT                   /note="Parvalbumin beta 3"
FT                   /id="PRO_0000399430"
FT   DOMAIN          39..66
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          77..>95
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         44
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P02621,
FT                   ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         46
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P02621,
FT                   ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         48
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P02621,
FT                   ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         50
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P02621"
FT   BINDING         52
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P02621"
FT   BINDING         55
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P02621,
FT                   ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         77
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P02621,
FT                   ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         79
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P02621,
FT                   ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         81
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P02621,
FT                   ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         83
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         88
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P02621,
FT                   ECO:0000255|PROSITE-ProRule:PRU00448"
FT   MOD_RES         1
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          6
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          11
FT                   /note="I or L"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          12
FT                   /note="K or Q"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          15
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          27
FT                   /note="K or Q"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          31
FT                   /note="K or Q"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          35
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          38
FT                   /note="K or Q"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          42
FT                   /note="I or L"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          43
FT                   /note="I or L"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          45
FT                   /note="Q or K"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          51
FT                   /note="I or L"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          56
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          57
FT                   /note="K or Q"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          58
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          60
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          61
FT                   /note="Q or K"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          70
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          76
FT                   /note="K or Q"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          84
FT                   /note="I or L"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          92
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   UNSURE          94
FT                   /note="K or Q"
FT                   /evidence="ECO:0000269|PubMed:20586483"
FT   NON_CONS        38..39
FT                   /evidence="ECO:0000303|PubMed:20586483"
FT   NON_CONS        76..77
FT                   /evidence="ECO:0000303|PubMed:20586483"
FT   NON_TER         95
FT                   /evidence="ECO:0000303|PubMed:20586483"
SQ   SEQUENCE   95 AA;  9959 MW;  98E15C03D8599736 CRC64;
     AFAGVLADAD IKAALAGCAA AESFNYKTFF KACGLAGKFF AIIDQDHSGF IEEDELKLFL
     QTFSAGARAL SDAETKDVDG DGMIGVDEFV ALVKA
 
 
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