PRVB3_MERPA
ID PRVB3_MERPA Reviewed; 95 AA.
AC P86770;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 1.
DT 03-AUG-2022, entry version 28.
DE RecName: Full=Parvalbumin beta 3 {ECO:0000303|PubMed:20586483};
DE Flags: Fragments;
OS Merluccius paradoxus (Deep-water Cape hake) (Merluccius capensis
OS paradoxus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Zeiogadaria; Gadariae; Gadiformes; Gadoidei; Merlucciidae; Merluccius.
OX NCBI_TaxID=89950;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, AND ACETYLATION AT ALA-1.
RC TISSUE=Muscle {ECO:0000269|PubMed:20586483};
RX PubMed=20586483; DOI=10.1021/pr100163e;
RA Carrera M., Canas B., Vazquez J., Gallardo J.M.;
RT "Extensive de novo sequencing of new parvalbumin isoforms using a novel
RT combination of bottom-up proteomics, accurate molecular mass measurement by
RT FTICR-MS, and selected MS/MS ion monitoring.";
RL J. Proteome Res. 9:4393-4406(2010).
CC -!- FUNCTION: In muscle, parvalbumin is thought to be involved in
CC relaxation after contraction. It binds two calcium ions (By
CC similarity). {ECO:0000250|UniProtKB:P02622,
CC ECO:0000250|UniProtKB:P02624}.
CC -!- MISCELLANEOUS: Is regarded as an important allergen.
CC {ECO:0000250|UniProtKB:P02622, ECO:0000269|PubMed:20586483}.
CC -!- MISCELLANEOUS: On the 2D-gel the determined pI of this protein is:
CC 3.79, its MW is: 11.32 kDa. {ECO:0000269|PubMed:20586483}.
CC -!- SIMILARITY: Belongs to the parvalbumin family. {ECO:0000255}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; P86770; -.
DR SMR; P86770; -.
DR iPTMnet; P86770; -.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR008080; Parvalbumin.
DR PANTHER; PTHR11653; PTHR11653; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 1: Evidence at protein level;
KW Acetylation; Allergen; Calcium; Direct protein sequencing; Metal-binding;
KW Muscle protein; Repeat.
FT CHAIN 1..>95
FT /note="Parvalbumin beta 3"
FT /id="PRO_0000399430"
FT DOMAIN 39..66
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 77..>95
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 44
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 46
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 48
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 50
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02621"
FT BINDING 52
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02621"
FT BINDING 55
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 77
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 79
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 81
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 83
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 88
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P02621,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT MOD_RES 1
FT /note="N-acetylalanine"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 6
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 11
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 12
FT /note="K or Q"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 15
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 27
FT /note="K or Q"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 31
FT /note="K or Q"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 35
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 38
FT /note="K or Q"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 42
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 43
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 45
FT /note="Q or K"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 51
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 56
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 57
FT /note="K or Q"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 58
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 60
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 61
FT /note="Q or K"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 70
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 76
FT /note="K or Q"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 84
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 92
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:20586483"
FT UNSURE 94
FT /note="K or Q"
FT /evidence="ECO:0000269|PubMed:20586483"
FT NON_CONS 38..39
FT /evidence="ECO:0000303|PubMed:20586483"
FT NON_CONS 76..77
FT /evidence="ECO:0000303|PubMed:20586483"
FT NON_TER 95
FT /evidence="ECO:0000303|PubMed:20586483"
SQ SEQUENCE 95 AA; 9959 MW; 98E15C03D8599736 CRC64;
AFAGVLADAD IKAALAGCAA AESFNYKTFF KACGLAGKFF AIIDQDHSGF IEEDELKLFL
QTFSAGARAL SDAETKDVDG DGMIGVDEFV ALVKA
