PRVB_TRAJP
ID PRVB_TRAJP Reviewed; 107 AA.
AC Q3C2C4;
DT 05-JUN-2019, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Parvalbumin beta {ECO:0000305};
DE AltName: Full=Dark muscle parvalbumin {ECO:0000303|PubMed:16436146, ECO:0000312|EMBL:BAE46763.1};
DE Short=aji-DPA {ECO:0000312|EMBL:BAE46763.1};
DE AltName: Full=White muscle parvalbumin {ECO:0000303|PubMed:16436146, ECO:0000312|EMBL:BAE46762.1};
DE Short=aji-WPA {ECO:0000312|EMBL:BAE46762.1};
DE AltName: Allergen=Tra j 1 {ECO:0000305};
OS Trachurus japonicus (Japanese jack mackerel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Trachurus.
OX NCBI_TaxID=83875 {ECO:0000312|EMBL:BAE46763.1};
RN [1] {ECO:0000312|EMBL:BAE46763.1}
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND ALLERGEN.
RC TISSUE=Muscle {ECO:0000303|PubMed:16436146};
RX PubMed=16436146; DOI=10.1111/j.1398-9995.2006.00966.x;
RA Kobayashi A., Tanaka H., Hamada Y., Ishizaki S., Nagashima Y., Shiomi K.;
RT "Comparison of allergenicity and allergens between fish white and dark
RT muscles.";
RL Allergy 61:357-363(2006).
CC -!- FUNCTION: In muscle, parvalbumin is thought to be involved in
CC relaxation after contraction. It binds two calcium ions.
CC {ECO:0000250|UniProtKB:P86432}.
CC -!- TISSUE SPECIFICITY: Expressed in both white and dark muscles (at
CC protein level). About five times lower expression in the dark muscle
CC than in the white muscle (at protein level).
CC {ECO:0000269|PubMed:16436146}.
CC -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE in
CC patients allergic to fish parvalbumin. {ECO:0000269|PubMed:16436146}.
CC -!- SIMILARITY: Belongs to the parvalbumin family. {ECO:0000255,
CC ECO:0000305}.
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DR EMBL; AB211364; BAE46762.1; -; mRNA.
DR EMBL; AB211365; BAE46763.1; -; mRNA.
DR AlphaFoldDB; Q3C2C4; -.
DR SMR; Q3C2C4; -.
DR Allergome; 2713; Tra j 1.
DR GO; GO:0005509; F:calcium ion binding; ISS:UniProtKB.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR008080; Parvalbumin.
DR PANTHER; PTHR11653; PTHR11653; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 1: Evidence at protein level;
KW Allergen; Calcium; Metal-binding; Muscle protein; Repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P09227"
FT CHAIN 2..107
FT /note="Parvalbumin beta"
FT /id="PRO_0000447296"
FT DOMAIN 37..72
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 76..107
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 50
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P59747,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 52
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P59747,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 54
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P59747,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 56
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P59747"
FT BINDING 61
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P59747,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 89
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P59747,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 91
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P59747,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 93
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P59747,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 95
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P59747,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 100
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P59747,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
SQ SEQUENCE 107 AA; 11340 MW; 8BCFCF7BAC76472B CRC64;
MAFKGVLNDA DVTAALDGCK SAFDHKAFFK ACGLAAKSAD DIKKAFAIID QDKSGFIEED
ELKLFLQNFC AGARALSDAE TKAFLKAGDS DGDGKIGVDE FAAMVKH
