PRVU_CHICK
ID PRVU_CHICK Reviewed; 109 AA.
AC P43305;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Parvalbumin, thymic CPV3;
DE AltName: Full=Parvalbumin-3;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Thymus;
RX PubMed=8106513; DOI=10.1016/s0021-9258(17)37686-x;
RA Hapak R.C., Zhao H., Boschi J.M., Henzl M.T.;
RT "Novel avian thymic parvalbumin displays high degree of sequence homology
RT to oncomodulin.";
RL J. Biol. Chem. 269:5288-5296(1994).
RN [2]
RP STRUCTURE BY NMR OF 2-109 OF APOPROTEIN AND IN COMPLEX WITH CALCIUM IONS,
RP AND FUNCTION.
RX PubMed=21287610; DOI=10.1002/prot.22915;
RA Henzl M.T., Tanner J.J., Tan A.;
RT "Solution structures of chicken parvalbumin 3 in the Ca(2+)-free and
RT Ca(2+)-bound states.";
RL Proteins 79:752-764(2011).
CC -!- FUNCTION: Binds two calcium ions. {ECO:0000269|PubMed:21287610}.
CC -!- TISSUE SPECIFICITY: Restricted to the thymic stroma.
CC -!- MISCELLANEOUS: This parvalbumin has an isoelectric point of 4.6.
CC -!- SIMILARITY: Belongs to the parvalbumin family. {ECO:0000305}.
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DR EMBL; U03850; AAA17518.1; -; mRNA.
DR PIR; A53341; A53341.
DR RefSeq; NP_989753.1; NM_204422.1.
DR RefSeq; XP_015149613.1; XM_015294127.1.
DR PDB; 2KYC; NMR; -; A=2-109.
DR PDB; 2KYF; NMR; -; A=2-109.
DR PDBsum; 2KYC; -.
DR PDBsum; 2KYF; -.
DR AlphaFoldDB; P43305; -.
DR BMRB; P43305; -.
DR SMR; P43305; -.
DR STRING; 9031.ENSGALP00000005475; -.
DR PaxDb; P43305; -.
DR Ensembl; ENSGALT00000005485; ENSGALP00000005475; ENSGALG00000003462.
DR GeneID; 386586; -.
DR KEGG; gga:386586; -.
DR CTD; 100485867; -.
DR VEuPathDB; HostDB:geneid_386586; -.
DR eggNOG; KOG0027; Eukaryota.
DR GeneTree; ENSGT00940000163861; -.
DR HOGENOM; CLU_157356_0_0_1; -.
DR InParanoid; P43305; -.
DR OMA; KKFFQVC; -.
DR OrthoDB; 1524081at2759; -.
DR PhylomeDB; P43305; -.
DR TreeFam; TF332342; -.
DR EvolutionaryTrace; P43305; -.
DR PRO; PR:P43305; -.
DR Proteomes; UP000000539; Chromosome 14.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR008080; Parvalbumin.
DR PANTHER; PTHR11653; PTHR11653; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Calcium; Metal-binding; Reference proteome; Repeat.
FT CHAIN 1..109
FT /note="Parvalbumin, thymic CPV3"
FT /id="PRO_0000073627"
FT DOMAIN 39..74
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 78..109
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 52
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 54
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 56
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 63
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 91
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 93
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 95
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 97
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 102
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT STRAND 5..7
FT /evidence="ECO:0007829|PDB:2KYC"
FT HELIX 9..16
FT /evidence="ECO:0007829|PDB:2KYC"
FT TURN 22..24
FT /evidence="ECO:0007829|PDB:2KYC"
FT HELIX 27..30
FT /evidence="ECO:0007829|PDB:2KYC"
FT TURN 31..35
FT /evidence="ECO:0007829|PDB:2KYC"
FT STRAND 41..43
FT /evidence="ECO:0007829|PDB:2KYC"
FT HELIX 44..47
FT /evidence="ECO:0007829|PDB:2KYC"
FT STRAND 49..51
FT /evidence="ECO:0007829|PDB:2KYC"
FT STRAND 56..60
FT /evidence="ECO:0007829|PDB:2KYF"
FT HELIX 61..63
FT /evidence="ECO:0007829|PDB:2KYC"
FT TURN 64..66
FT /evidence="ECO:0007829|PDB:2KYC"
FT HELIX 68..71
FT /evidence="ECO:0007829|PDB:2KYC"
FT STRAND 72..74
FT /evidence="ECO:0007829|PDB:2KYC"
FT TURN 80..83
FT /evidence="ECO:0007829|PDB:2KYC"
FT HELIX 84..87
FT /evidence="ECO:0007829|PDB:2KYC"
FT TURN 88..90
FT /evidence="ECO:0007829|PDB:2KYC"
FT STRAND 93..96
FT /evidence="ECO:0007829|PDB:2KYC"
FT HELIX 102..108
FT /evidence="ECO:0007829|PDB:2KYC"
SQ SEQUENCE 109 AA; 12107 MW; FDA3BB1907D59757 CRC64;
MSLTDILSPS DIAAALRDCQ APDSFSPKKF FQISGMSKKS SSQLKEIFRI LDNDQSGFIE
EDELKYFLQR FECGARVLTA SETKTFLAAA DHDGDGKIGA EEFQEMVQS
