ID   PRW1_SCHPO              Reviewed;         431 AA.
AC   O14021;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 160.
DE   RecName: Full=RbAp48-related WD40 repeat-containing protein prw1;
GN   Name=prw1; ORFNames=SPAC29A4.18;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   PROTEIN SEQUENCE OF 12-24; 36-47 AND 318-349, IDENTIFICATION, FUNCTION,
RP   SUBUNIT, AND SUBCELLULAR LOCATION.
RX   PubMed=12773392; DOI=10.1093/emboj/cdg248;
RA   Nakayama J., Xiao G., Noma K., Malikzay A., Bjerling P., Ekwall K.,
RA   Kobayashi R., Grewal S.I.S.;
RT   "Alp13, an MRG family protein, is a component of fission yeast Clr6 histone
RT   deacetylase required for genomic integrity.";
RL   EMBO J. 22:2776-2787(2003).
CC   -!- FUNCTION: Has a role in chromatin assembly and chromosome segregation.
CC       Involved in the deacetylation of histones.
CC       {ECO:0000269|PubMed:12773392}.
CC   -!- SUBUNIT: Heterotetramer of alp13, clr6, prw1 and pst2.
CC       {ECO:0000269|PubMed:12773392}.
CC   -!- INTERACTION:
CC       O14021; O13919: pst2; NbExp=3; IntAct=EBI-904698, EBI-904686;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12773392}.
CC   -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAB10144.1; -; Genomic_DNA.
DR   PIR; T38471; T38471.
DR   RefSeq; NP_594864.1; NM_001020293.2.
DR   AlphaFoldDB; O14021; -.
DR   SMR; O14021; -.
DR   BioGRID; 278295; 406.
DR   DIP; DIP-29342N; -.
DR   IntAct; O14021; 8.
DR   STRING; 4896.SPAC29A4.18.1; -.
DR   MaxQB; O14021; -.
DR   PaxDb; O14021; -.
DR   PRIDE; O14021; -.
DR   EnsemblFungi; SPAC29A4.18.1; SPAC29A4.18.1:pep; SPAC29A4.18.
DR   GeneID; 2541804; -.
DR   KEGG; spo:SPAC29A4.18; -.
DR   PomBase; SPAC29A4.18; prw1.
DR   VEuPathDB; FungiDB:SPAC29A4.18; -.
DR   eggNOG; KOG0264; Eukaryota.
DR   HOGENOM; CLU_020445_3_1_1; -.
DR   InParanoid; O14021; -.
DR   OMA; CINEEYK; -.
DR   PhylomeDB; O14021; -.
DR   Reactome; R-SPO-3214815; HDACs deacetylate histones.
DR   Reactome; R-SPO-3214847; HATs acetylate histones.
DR   Reactome; R-SPO-8951664; Neddylation.
DR   PRO; PR:O14021; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:1990483; C:Clr6 histone deacetylase complex I''; IPI:PomBase.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; IDA:PomBase.
DR   GO; GO:0033698; C:Rpd3L complex; IDA:PomBase.
DR   GO; GO:0070210; C:Rpd3L-Expanded complex; IDA:PomBase.
DR   GO; GO:0032221; C:Rpd3S/Clr6-CII complex; IDA:PomBase.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0006338; P:chromatin remodeling; IMP:PomBase.
DR   GO; GO:0016575; P:histone deacetylation; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR022052; Histone-bd_RBBP4_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF12265; CAF1C_H4-bd; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Chromatin regulator; Direct protein sequencing; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation;
KW   WD repeat.
FT   CHAIN           1..431
FT                   /note="RbAp48-related WD40 repeat-containing protein prw1"
FT                   /id="PRO_0000051170"
FT   REPEAT          127..159
FT                   /note="WD 1"
FT   REPEAT          182..213
FT                   /note="WD 2"
FT   REPEAT          232..263
FT                   /note="WD 3"
FT   REPEAT          279..310
FT                   /note="WD 4"
FT   REPEAT          323..354
FT                   /note="WD 5"
FT   REPEAT          380..411
FT                   /note="WD 6"
SQ   SEQUENCE   431 AA;  48476 MW;  4AFF1BDA12C4DBC2 CRC64;
     MAVSAVPHPS KQAQASEEGI NQEKCINEEY KIWKKNSPFL YDLIITRALE WPCMSLQWYP
     EQQIFAEHGY TEQKMFLGVR ADVGKYLLAV ASIQLPYLNQ TVPPTTMEGA SAGDESSLRV
     NISNLYSHPE SVCSAKLMPQ DDSCVATVGN YHNDVLVFDK ESFESYSSAS ESPLKPKYRL
     TKHTQPCTSV CWNFLSKGTL VSGSQDATLS CWDLNAYNES DSASVLKVHI SSHEKQVSDV
     RFHYKHQDLL ASVSYDQYLH VHDIRRPDAS TKPARSVHAH SGPIHSVAFN PHNDFILATC
     STDKTIALWD LRNLNQRLHT LEGHEDIVTK ISFSPHEEPI LASTSADRRT LVWDLSRIGE
     DQPAEEAQDG PPELLFMHGG HTSCTIDMDW CPNYNWTMAT AAEDNILQIW TPSRSIWGNE
     QLEEDATAYL S