ID   AAC4_DICDI              Reviewed;         678 AA.
AC   P14198; C7FZW0; Q55GW7;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   19-JAN-2010, sequence version 3.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=AAC-rich mRNA clone AAC4 protein;
GN   Name=AAC4; ORFNames=DDB_G0267458;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-312, AND DEVELOPMENTAL STAGE.
RX   PubMed=2511421; DOI=10.1007/bf00332409;
RA   Shaw D.R., Richter H., Giorda R., Ohmachi T., Ennis H.L.;
RT   "Nucleotide sequences of Dictyostelium discoideum developmentally regulated
RT   cDNAs rich in (AAC) imply proteins that contain clusters of asparagine,
RT   glutamine, or threonine.";
RL   Mol. Gen. Genet. 218:453-459(1989).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: The concentration of AAC-rich mRNAs is low in
CC       dormant spores and growing cells, but increases during spore-
CC       germination and multicellular development.
CC       {ECO:0000269|PubMed:2511421}.
CC   -!- MISCELLANEOUS: Several proteins derive from AAC-rich mRNA, which, due
CC       to a frameshift also have ACA and CAA codons and thus are Asn-, Thr- or
CC       Gln-rich.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA34530.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AAFI02000003; EEU04156.1; -; Genomic_DNA.
DR   EMBL; X16523; CAA34530.1; ALT_FRAME; mRNA.
DR   PIR; S05356; S05356.
DR   RefSeq; XP_002649206.2; XM_002649160.1.
DR   AlphaFoldDB; P14198; -.
DR   PaxDb; P14198; -.
DR   GeneID; 8615872; -.
DR   KEGG; ddi:DDB_G0267458; -.
DR   dictyBase; DDB_G0267458; -.
DR   eggNOG; ENOG502S3F1; Eukaryota.
DR   HOGENOM; CLU_405694_0_0_1; -.
DR   InParanoid; P14198; -.
DR   PRO; PR:P14198; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           1..678
FT                   /note="AAC-rich mRNA clone AAC4 protein"
FT                   /id="PRO_0000064414"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          55..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          318..347
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        51
FT                   /note="K -> E (in Ref. 2; CAA34530)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   678 AA;  77544 MW;  A34C8F9C74796DD8 CRC64;
     MSLSNNQTQF VTVFVPIQLS IDVFRKMNNI NSFVNDNLTN FPIVTVDQLI KVVNNNNNNN
     NNNNNNNNNN NNNTSISNNG DINNCLATFE QVQNNCFETC DFKATEREHY FASGKQIQES
     VLPEEEEEKI SVNNFAMVTV EPNNCFVKAQ QINSVAPLSL DNRNCVRRAH REVNTFVQVF
     DVCVFNLKVV NVATNESQVN LFNGGNVENI CFDRSIQMPR SSADDFDWSS QQQSSWYSLA
     LSIIPIYHEI ILVLCNWLVV AFYKYWQHQQ QKQLPPHPLN IIVPNVSKRI AVNLNNQLIS
     LTFTNFLKNI FFLNNNNNNN NNNNNNNNNN NNNNNNNNNN NKTNNNQLNL SKEICNENLN
     FEEFNFEDES VCKYNRLTNS CENISKIQQV NEESELLDWF SDFEEMDSVL LQNGTEFDND
     HPMVKSQAPS ITFKSLDQFI KYLEENNCVD DIEVSPCSKS HTFNRPVSTP RLIIKPTWCV
     YGDSLNTEFF HSCLKDKTCG DIIVDHFEPL VSSPTDFLLS NGGQRILDTP NAGGSSVWSE
     VLSFEVLNQV FGAQLKKTET EIEYAPGSKI TDFSVDINNS HIGVSVVRII NFFDLNGRTY
     KAVFTPEYAR NLLYKKLFGV IASTEAVVDK WEKQILYVWT TSSCVADIIV QEYWKVPAKL
     RSNTLVYVNH ATNSEFLF