PRXD1_MOUSE
ID PRXD1_MOUSE Reviewed; 169 AA.
AC Q9D820; Q8BFX7;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Prolyl-tRNA synthetase associated domain-containing protein 1;
DE AltName: Full=PrdX deacylase domain-containing protein 1;
GN Name=Prorsd1; Synonyms=Prdxdd1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Heart, Ovary, Small intestine, and Uterus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D820-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D820-2; Sequence=VSP_032962;
CC -!- SIMILARITY: Belongs to the PRORSD1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAI36003.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK008574; BAB25753.1; -; mRNA.
DR EMBL; AK077280; BAC36727.1; -; mRNA.
DR EMBL; AK085965; BAC39579.1; -; mRNA.
DR EMBL; BX284634; CAI36004.1; -; Genomic_DNA.
DR EMBL; BX284634; CAI36003.2; ALT_SEQ; Genomic_DNA.
DR EMBL; BC033930; AAH33930.1; -; mRNA.
DR EMBL; BC115900; AAI15901.1; -; mRNA.
DR CCDS; CCDS24495.1; -. [Q9D820-1]
DR RefSeq; NP_001156926.1; NM_001163454.2.
DR RefSeq; NP_080741.1; NM_026465.3. [Q9D820-1]
DR AlphaFoldDB; Q9D820; -.
DR SMR; Q9D820; -.
DR STRING; 10090.ENSMUSP00000048099; -.
DR iPTMnet; Q9D820; -.
DR PhosphoSitePlus; Q9D820; -.
DR EPD; Q9D820; -.
DR MaxQB; Q9D820; -.
DR PaxDb; Q9D820; -.
DR PeptideAtlas; Q9D820; -.
DR PRIDE; Q9D820; -.
DR ProteomicsDB; 291758; -. [Q9D820-1]
DR ProteomicsDB; 291759; -. [Q9D820-2]
DR DNASU; 67939; -.
DR Ensembl; ENSMUST00000039900; ENSMUSP00000048099; ENSMUSG00000032673. [Q9D820-1]
DR GeneID; 67939; -.
DR KEGG; mmu:67939; -.
DR UCSC; uc007igz.2; mouse. [Q9D820-1]
DR CTD; 67939; -.
DR MGI; MGI:1915189; Prorsd1.
DR VEuPathDB; HostDB:ENSMUSG00000032673; -.
DR eggNOG; ENOG502QT6S; Eukaryota.
DR GeneTree; ENSGT00440000033965; -.
DR HOGENOM; CLU_104635_2_1_1; -.
DR InParanoid; Q9D820; -.
DR OMA; CHPLSND; -.
DR OrthoDB; 907445at2759; -.
DR PhylomeDB; Q9D820; -.
DR TreeFam; TF329697; -.
DR BioGRID-ORCS; 67939; 4 hits in 68 CRISPR screens.
DR ChiTaRS; Prorsd1; mouse.
DR PRO; PR:Q9D820; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9D820; protein.
DR Bgee; ENSMUSG00000032673; Expressed in lobe of prostate and 214 other tissues.
DR ExpressionAtlas; Q9D820; baseline and differential.
DR Genevisible; Q9D820; MM.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR Gene3D; 3.90.960.10; -; 1.
DR InterPro; IPR040285; ProX/PRXD1.
DR InterPro; IPR036754; YbaK/aa-tRNA-synt-asso_dom_sf.
DR InterPro; IPR007214; YbaK/aa-tRNA-synth-assoc-dom.
DR PANTHER; PTHR31423; PTHR31423; 1.
DR Pfam; PF04073; tRNA_edit; 1.
DR SUPFAM; SSF55826; SSF55826; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..169
FT /note="Prolyl-tRNA synthetase associated domain-containing
FT protein 1"
FT /id="PRO_0000329287"
FT VAR_SEQ 1..34
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_032962"
SQ SEQUENCE 169 AA; 18862 MW; C225608758771B7C CRC64;
MAGSELRAEL EQRLGALAIR TEVVEHPEVF TIEEMMPHIQ HLKGAHSKNL FLKDKKKKNY
WLVTVLHDRQ INLNDLGKQL GVGSGNLRFA DETAMLEKLK VGQGCATPLS LFCDDGDVKF
VLDSAFLEGG HEKVYFHPMT NAATMGLSPE DFLIFVKATG HDPIILNFD
