PRY1_CANAL
ID PRY1_CANAL Reviewed; 410 AA.
AC Q59PV6; A0A1D8PE32; Q59PY0;
DT 19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Secreted protein PRY1;
DE AltName: Full=PRY family protein 1;
DE AltName: Full=Pathogenesis-related protein 1;
DE Flags: Precursor;
GN Name=PRY1; OrderedLocusNames=CAALFM_C107580CA;
GN ORFNames=CaO19.10303, CaO19.2787;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP IDENTIFICATION.
RX PubMed=12456000; DOI=10.1128/ec.1.4.514-525.2002;
RA Monteoliva L., Matas M.L., Gil C., Nombela C., Pla J.;
RT "Large-scale identification of putative exported proteins in Candida
RT albicans by genetic selection.";
RL Eukaryot. Cell 1:514-525(2002).
RN [5]
RP INDUCTION.
RX PubMed=14622594; DOI=10.1016/s0092-8674(03)00885-7;
RA Tsong A.E., Miller M.G., Raisner R.M., Johnson A.D.;
RT "Evolution of a combinatorial transcriptional circuit: a case study in
RT yeasts.";
RL Cell 115:389-399(2003).
RN [6]
RP INDUCTION.
RX PubMed=16987174; DOI=10.1111/j.1365-2958.2006.05367.x;
RA Bennett R.J., Johnson A.D.;
RT "The role of nutrient regulation and the Gpa2 protein in the mating
RT pheromone response of C. albicans.";
RL Mol. Microbiol. 62:100-119(2006).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, AND INDUCTION.
RX PubMed=20641015; DOI=10.1002/yea.1775;
RA Sorgo A.G., Heilmann C.J., Dekker H.L., Brul S., de Koster C.G., Klis F.M.;
RT "Mass spectrometric analysis of the secretome of Candida albicans.";
RL Yeast 27:661-672(2010).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, AND INDUCTION.
RX PubMed=22997008; DOI=10.1002/pmic.201200228;
RA Ene I.V., Heilmann C.J., Sorgo A.G., Walker L.A., de Koster C.G.,
RA Munro C.A., Klis F.M., Brown A.J.;
RT "Carbon source-induced reprogramming of the cell wall proteome and
RT secretome modulates the adherence and drug resistance of the fungal
RT pathogen Candida albicans.";
RL Proteomics 12:3164-3179(2012).
RN [9]
RP IDENTIFICATION, AND INDUCTION.
RX PubMed=23136884; DOI=10.1111/mmi.12087;
RA Rohm M., Lindemann E., Hiller E., Ermert D., Lemuth K., Trkulja D.,
RA Sogukpinar O., Brunner H., Rupp S., Urban C.F., Sohn K.;
RT "A family of secreted pathogenesis-related proteins in Candida albicans.";
RL Mol. Microbiol. 87:132-151(2013).
CC -!- FUNCTION: Secreted protein that acts as a virulence factor during
CC infections. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20641015,
CC ECO:0000269|PubMed:22997008}.
CC -!- INDUCTION: Expression is specific to in opaque cells, in presence of
CC lactate, and during hyphal growth. Expression is repressed in response
CC to alpha pheromone. {ECO:0000269|PubMed:14622594,
CC ECO:0000269|PubMed:16987174, ECO:0000269|PubMed:20641015,
CC ECO:0000269|PubMed:22997008, ECO:0000269|PubMed:23136884}.
CC -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
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DR EMBL; CP017623; AOW26405.1; -; Genomic_DNA.
DR RefSeq; XP_711729.1; XM_706637.1.
DR AlphaFoldDB; Q59PV6; -.
DR SMR; Q59PV6; -.
DR STRING; 237561.Q59PV6; -.
DR GeneID; 3646674; -.
DR KEGG; cal:CAALFM_C107580CA; -.
DR CGD; CAL0000185546; PRY1.
DR VEuPathDB; FungiDB:C1_07580C_A; -.
DR eggNOG; KOG3017; Eukaryota.
DR HOGENOM; CLU_035730_3_1_1; -.
DR OrthoDB; 1528782at2759; -.
DR PRO; PR:Q59PV6; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:0005576; C:extracellular region; IDA:CGD.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR Gene3D; 3.40.33.10; -; 1.
DR InterPro; IPR014044; CAP_domain.
DR InterPro; IPR035940; CAP_sf.
DR InterPro; IPR001283; CRISP-related.
DR PANTHER; PTHR10334; PTHR10334; 1.
DR Pfam; PF00188; CAP; 1.
DR PRINTS; PR00837; V5TPXLIKE.
DR SMART; SM00198; SCP; 1.
DR SUPFAM; SSF55797; SSF55797; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..410
FT /note="Secreted protein PRY1"
FT /id="PRO_0000425797"
FT DOMAIN 283..394
FT /note="SCP"
FT REGION 64..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 148..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 410 AA; 41180 MW; 99E659816EC1E115 CRC64;
MKQNYILSII LCYLLANVHS APAIITVWQT VTDAQVAAGP TAAAPAANAN ANVQQAAAAS
APAPAPVASP AAPAPASSAP QSSTPSSSGW LSNLFNSFFG GSDSDSSSGS DTASAAPAST
SPQSSSSSSS SSGNSFLSFL SGLFGSGSSS STPSSISQQQ QQQQGSPASG SNSPNSAQPD
AAAASNPVPQ SNNNQGSGLG SGFGSGFGSG SGSDSDSGSG LPSASSSTII QQQPSSSNIG
SSSTSSSSSS SSSSSSSSSS SGDIYAAISQ CDGIDASFAS EILDAHNKYR AQHKVGDLSW
DVDTYNYAKN NADNYDCSGV LTHTHGKFGE NLAAGFKDGA STVAAWVDEP ISYSDASFVY
NHFTQVIWKG STKVGCAYKD CRKSNWGLYV VCEYDPYGNV IGQGSKNVFP
