PRY_HUMAN
ID PRY_HUMAN Reviewed; 147 AA.
AC O14603; B7ZLM1; Q14D09;
DT 13-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=PTPN13-like protein, Y-linked;
DE AltName: Full=Testis-specific PTP-BL-related Y protein;
GN Name=PRY; Synonyms=PRY1, PTPN13LY;
GN and
GN Name=PRY2; Synonyms=PTPN13LY2;
GN and
GN Name=PRYP3;
GN and
GN Name=PRYP4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=9381176; DOI=10.1126/science.278.5338.675;
RA Lahn B.T., Page D.C.;
RT "Functional coherence of the human Y chromosome.";
RL Science 278:675-680(1997).
RN [2]
RP SEQUENCE REVISION.
RA Lahn B.T., Page D.C.;
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=12815422; DOI=10.1038/nature01722;
RA Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W.,
RA Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A.,
RA Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R.,
RA Graves T.A., Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R.,
RA McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S.,
RA Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P.,
RA Waterston R.H., Wilson R.K., Rozen S., Page D.C.;
RT "The male-specific region of the human Y chromosome is a mosaic of discrete
RT sequence classes.";
RL Nature 423:825-837(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=11420382; DOI=10.1093/molehr/7.7.603;
RA Stouffs K., Lissens W., Van Landuyt L., Tournaye H., Van Steirteghem A.,
RA Liebaers I.;
RT "Characterization of the genomic organization, localization and expression
RT of four PRY genes (PRY1, PRY2, PRY3 and PRY4).";
RL Mol. Hum. Reprod. 7:603-610(2001).
RN [7]
RP TISSUE SPECIFICITY.
RX PubMed=14665702; DOI=10.1093/molehr/gah010;
RA Stouffs K., Lissens W., Verheyen G., Van Landuyt L., Goossens A.,
RA Tournaye H., Van Steirteghem A., Liebaers I.;
RT "Expression pattern of the Y-linked PRY gene suggests a function in
RT apoptosis but not in spermatogenesis.";
RL Mol. Hum. Reprod. 10:15-21(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O14603-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O14603-2; Sequence=VSP_004068, VSP_004069;
CC -!- TISSUE SPECIFICITY: Expressed in testis. Detected in spermatocytes,
CC spermatids and spermatozoa (at protein level).
CC {ECO:0000269|PubMed:11420382, ECO:0000269|PubMed:14665702}.
CC -!- CAUTION: PRY has multiple identical or highly similar copies on
CC chromosome Y, some of which might be non functional pseudogenes.
CC {ECO:0000305}.
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DR EMBL; AF000988; AAC51835.2; -; mRNA.
DR EMBL; AF517635; AAN06674.1; -; mRNA.
DR EMBL; CH878735; EAW61212.1; -; Genomic_DNA.
DR EMBL; BC113548; AAI13549.1; -; mRNA.
DR EMBL; BC113550; AAI13551.1; -; mRNA.
DR EMBL; BC143893; AAI43894.1; -; mRNA.
DR EMBL; BC171757; AAI71757.1; -; mRNA.
DR CCDS; CCDS14799.1; -. [O14603-1]
DR CCDS; CCDS35482.1; -. [O14603-1]
DR RefSeq; NP_001002758.1; NM_001002758.1. [O14603-1]
DR RefSeq; NP_004667.2; NM_004676.2. [O14603-1]
DR RefSeq; XP_016885577.1; XM_017030088.1. [O14603-1]
DR AlphaFoldDB; O14603; -.
DR BioGRID; 114537; 1.
DR BioGRID; 138577; 1.
DR BioMuta; PRY; -.
DR EPD; O14603; -.
DR PaxDb; O14603; -.
DR PRIDE; O14603; -.
DR Antibodypedia; 58336; 37 antibodies from 9 providers.
DR Antibodypedia; 65672; 17 antibodies from 7 providers.
DR DNASU; 9081; -.
DR Ensembl; ENST00000303728.5; ENSP00000302319.1; ENSG00000169789.10. [O14603-1]
DR Ensembl; ENST00000303804.5; ENSP00000303300.1; ENSG00000169807.10. [O14603-1]
DR Ensembl; ENST00000343584.10; ENSP00000499795.1; ENSG00000169763.15. [O14603-1]
DR Ensembl; ENST00000472391.1; ENSP00000474545.1; ENSG00000169807.10. [O14603-2]
DR Ensembl; ENST00000477123.1; ENSP00000474674.1; ENSG00000169789.10. [O14603-2]
DR GeneID; 442862; -.
DR GeneID; 9081; -.
DR KEGG; hsa:442862; -.
DR KEGG; hsa:9081; -.
DR MANE-Select; ENST00000303728.5; ENSP00000302319.1; NM_004676.2; NP_004667.2.
DR MANE-Select; ENST00000303804.5; ENSP00000303300.1; NM_001002758.1; NP_001002758.1.
DR UCSC; uc004fuy.1; human. [O14603-1]
DR CTD; 442862; -.
DR CTD; 9081; -.
DR DisGeNET; 442862; -.
DR DisGeNET; 9081; -.
DR GeneCards; PRY; -.
DR GeneCards; PRY2; -.
DR GeneCards; PRYP3; -.
DR GeneCards; PRYP4; -.
DR GeneReviews; PRY; -.
DR GeneReviews; PRY2; -.
DR HGNC; HGNC:14024; PRY.
DR HGNC; HGNC:21504; PRY2.
DR HGNC; HGNC:34020; PRYP3.
DR HGNC; HGNC:34021; PRYP4.
DR HPA; ENSG00000169763; Group enriched (brain, epididymis).
DR HPA; ENSG00000169789; Not detected.
DR HPA; ENSG00000169807; Not detected.
DR MalaCards; PRY; -.
DR MalaCards; PRY2; -.
DR MIM; 400019; gene.
DR MIM; 400041; gene.
DR neXtProt; NX_O14603; -.
DR OpenTargets; ENSG00000169763; -.
DR PharmGKB; PA33844; -.
DR VEuPathDB; HostDB:ENSG00000169763; -.
DR VEuPathDB; HostDB:ENSG00000169789; -.
DR VEuPathDB; HostDB:ENSG00000169807; -.
DR GeneTree; ENSGT00390000001812; -.
DR HOGENOM; CLU_1839771_0_0_1; -.
DR InParanoid; O14603; -.
DR OrthoDB; 1577632at2759; -.
DR PhylomeDB; O14603; -.
DR TreeFam; TF341581; -.
DR PathwayCommons; O14603; -.
DR BioGRID-ORCS; 442862; 11 hits in 236 CRISPR screens.
DR BioGRID-ORCS; 9081; 9 hits in 202 CRISPR screens.
DR ChiTaRS; PRY; human.
DR ChiTaRS; PRY2; human.
DR ChiTaRS; PRYP3; human.
DR Pharos; O14603; Tdark.
DR PRO; PR:O14603; -.
DR Proteomes; UP000005640; Chromosome Y.
DR RNAct; O14603; protein.
DR Bgee; ENSG00000169763; Expressed in putamen and 15 other tissues.
DR ExpressionAtlas; O14603; baseline.
DR Genevisible; O14603; HS.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..147
FT /note="PTPN13-like protein, Y-linked"
FT /id="PRO_0000097056"
FT VAR_SEQ 63..71
FT /note="YGKVGCISL -> DGVSPCLPC (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12815422"
FT /id="VSP_004068"
FT VAR_SEQ 72..147
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12815422"
FT /id="VSP_004069"
SQ SEQUENCE 147 AA; 16512 MW; 87C861FC2BEDAE9B CRC64;
MGATGLGFLL SWRQDNLNGT DCQGCNILYF SETTGSMCSE LSLNRGLEAR RKKDLKDSFL
WRYGKVGCIS LPLREMTAWI NPPQISEIFQ GYHQRVHGAD ALSLQTNSLR SRLSSQCLGQ
SFLLRTLERG RGFRALGDIC GHVHEED
