ID   PS11A_DANRE             Reviewed;         421 AA.
AC   F6P3G4; A0AUR6;
DT   31-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   21-SEP-2011, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=26S proteasome non-ATPase regulatory subunit 11A;
DE   AltName: Full=26S proteasome regulatory subunit RPN6-A;
GN   Name=psmd11a;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-421.
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the lid subcomplex of the 26S proteasome, a
CC       multiprotein complex involved in the ATP-dependent degradation of
CC       ubiquitinated proteins. In the complex, psmd11a is required for
CC       proteasome assembly (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the lid subcomplex of the 19S proteasome
CC       regulatory particle complex (also named PA700 complex). The 26S
CC       proteasome consists of a 20S proteasome core and two 19S regulatory
CC       subunits (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytosol
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the proteasome subunit S9 family. {ECO:0000305}.
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DR   EMBL; BC124767; AAI24768.1; -; mRNA.
DR   EMBL; BX890565; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001159710.1; NM_001166238.2.
DR   RefSeq; XP_017209589.1; XM_017354100.1.
DR   AlphaFoldDB; F6P3G4; -.
DR   SMR; F6P3G4; -.
DR   STRING; 7955.ENSDARP00000078883; -.
DR   PaxDb; F6P3G4; -.
DR   Ensembl; ENSDART00000084448; ENSDARP00000078883; ENSDARG00000060150.
DR   Ensembl; ENSDART00000154696; ENSDARP00000129353; ENSDARG00000060150.
DR   GeneID; 503934; -.
DR   KEGG; dre:503934; -.
DR   CTD; 503934; -.
DR   ZFIN; ZDB-GENE-030131-2711; psmd11a.
DR   eggNOG; KOG1463; Eukaryota.
DR   GeneTree; ENSGT00530000063301; -.
DR   InParanoid; F6P3G4; -.
DR   OMA; LYFDTGM; -.
DR   OrthoDB; 1052430at2759; -.
DR   PhylomeDB; F6P3G4; -.
DR   TreeFam; TF106230; -.
DR   PRO; PR:F6P3G4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 3.
DR   Bgee; ENSDARG00000060150; Expressed in blastula and 29 other tissues.
DR   ExpressionAtlas; F6P3G4; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0022624; C:proteasome accessory complex; ISS:UniProtKB.
DR   GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IBA:GO_Central.
DR   GO; GO:0005198; F:structural molecule activity; IBA:GO_Central.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   GO; GO:0043248; P:proteasome assembly; ISS:UniProtKB.
DR   GO; GO:0048863; P:stem cell differentiation; ISS:UniProtKB.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR035295; PSMD11.
DR   InterPro; IPR040780; Rpn6_C_helix.
DR   InterPro; IPR040773; Rpn6_N.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10678:SF6; PTHR10678:SF6; 1.
DR   Pfam; PF01399; PCI; 1.
DR   Pfam; PF18503; RPN6_C_helix; 1.
DR   Pfam; PF18055; RPN6_N; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Proteasome; Reference proteome.
FT   CHAIN           1..421
FT                   /note="26S proteasome non-ATPase regulatory subunit 11A"
FT                   /id="PRO_0000419979"
FT   DOMAIN          227..391
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   421 AA;  47374 MW;  CF35933E98E8489D CRC64;
     MAATAVEFQR AQSLLSTDRN ASIDILHAIV KRDVQDDDEE AVRVKEQSIL ELGGLLAKTG
     QAAELGGLLK YVRPFLNSIS KAKAARLVRS LLDMFLDMEA ATGQEVELCL ECIEWAKSEK
     RTFLRQALEA RLVSLYFDTK RYQEALQLGS QLLQELKKMD DKALLVELQL LESKTYHALS
     NLPKARAALT SARTTANAIY CPPKLQAALD MQSGIIHAAE EKDWKTAYSY FYEAFEGYDS
     IDSPRAITAL KYMLLCKIML NSPEDVQSLI SGKLALRYAG RQTEALKCVA QASKNRSLAD
     FEKALTEYKA ELRDDPIIST HLTKLYDNLL EQNLIRVIEP FSRVQIEHIS ELIKLSKGDV
     ERKLSQMILD QKFHGILDQG EGVLIVFDEP PVDKTYEASL ETIQNMSKVV DSLYNKAKKL
     T