ID   PS11B_CAEBR             Reviewed;         411 AA.
AC   A8X379;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Probable 26S proteasome regulatory subunit rpn-6.2 {ECO:0000250|UniProtKB:P34481};
GN   Name=rpn-6.2 {ECO:0000250|UniProtKB:P34481}; ORFNames=CBG06851;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1] {ECO:0000312|EMBL:CAP27089.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Component of the lid subcomplex of the 26S proteasome, a
CC       multiprotein complex involved in the ATP-dependent degradation of
CC       ubiquitinated proteins. In the complex, rpn-6.2 is required for
CC       proteasome assembly (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the lid subcomplex of the 19S proteasome
CC       regulatory particle complex (also named PA700 complex). The 26S
CC       proteasome consists of a 20S proteasome core and two 19S regulatory
CC       subunits (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the proteasome subunit S9 family. {ECO:0000255}.
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DR   EMBL; HE601347; CAP27089.1; -; Genomic_DNA.
DR   RefSeq; XP_002642446.1; XM_002642400.1.
DR   AlphaFoldDB; A8X379; -.
DR   SMR; A8X379; -.
DR   STRING; 6238.CBG06851; -.
DR   EnsemblMetazoa; CBG06851.1; CBG06851.1; WBGene00029056.
DR   GeneID; 8584440; -.
DR   KEGG; cbr:CBG_06851; -.
DR   CTD; 8584440; -.
DR   WormBase; CBG06851; CBP07487; WBGene00029056; Cbr-rpn-6.2.
DR   eggNOG; KOG1463; Eukaryota.
DR   HOGENOM; CLU_029573_2_1_1; -.
DR   InParanoid; A8X379; -.
DR   OMA; KALKYMC; -.
DR   OrthoDB; 1052430at2759; -.
DR   Proteomes; UP000008549; Chromosome III.
DR   GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IBA:GO_Central.
DR   GO; GO:0005198; F:structural molecule activity; IBA:GO_Central.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR040773; Rpn6_N.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01399; PCI; 1.
DR   Pfam; PF18055; RPN6_N; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Proteasome; Reference proteome.
FT   CHAIN           1..411
FT                   /note="Probable 26S proteasome regulatory subunit rpn-6.2"
FT                   /id="PRO_0000399035"
FT   DOMAIN          212..381
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   411 AA;  46472 MW;  88A2B315EB811836 CRC64;
     MSSTPVTLKA VQSEVSARNA KSSEAEVKRC EDLILSYAKQ LAKEKDITGI RTLVKSIQNF
     YDLVGKARAS KLIRDIVEFA LTVEQGKQEK EEKIDLLKNC IEWATSNKRE FLRRSLQARL
     VRLYNDVREF TEGQKLGQEL SKELKKLEDR ELLIEVSIEE SKCAFNLNNL SKAKTALLTA
     KTSSNSAFAS PQLQAAVDMQ SGVLYSAEER DYKTSFSYFY EAFEGYGSIG DKVNATGALK
     YMILCKIMLN ETEQIPAMLS TKEVLPYNTS PRIVAIRAMA DAFRKRSLKD FMKALEEHKK
     ELVEDKVVAV HSQNLERTML EKEISRVIEP YSEIELSYIA RVIGMTVPPT EKAIARMILD
     KKLMGSIDQH GDTVVIYPKA GATKQFTRAL TTIRELTKTV DVSYSRTKVI K