PS11B_CAEEL
ID PS11B_CAEEL Reviewed; 416 AA.
AC P34481; C0P266; C0P267;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 3.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Probable 26S proteasome regulatory subunit rpn-6.2;
GN Name=rpn-6.2; ORFNames=F59B2.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Component of the lid subcomplex of the 26S proteasome, a
CC multiprotein complex involved in the ATP-dependent degradation of
CC ubiquitinated proteins. In the complex, rpn-6.2 is required for
CC proteasome assembly (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the lid subcomplex of the 19S proteasome
CC regulatory particle complex (also named PA700 complex). The 26S
CC proteasome consists of a 20S proteasome core and two 19S regulatory
CC subunits (By similarity). {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=P34481-1; Sequence=Displayed;
CC Name=b;
CC IsoId=P34481-2; Sequence=VSP_039826;
CC -!- SIMILARITY: Belongs to the proteasome subunit S9 family. {ECO:0000305}.
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DR EMBL; Z11505; CAX51679.1; -; Genomic_DNA.
DR EMBL; Z11505; CAX51680.1; -; Genomic_DNA.
DR PIR; S31125; S31125.
DR RefSeq; NP_001254972.1; NM_001268043.1. [P34481-1]
DR RefSeq; NP_001254973.1; NM_001268044.1. [P34481-2]
DR AlphaFoldDB; P34481; -.
DR SMR; P34481; -.
DR STRING; 6239.F59B2.5a; -.
DR PaxDb; P34481; -.
DR PeptideAtlas; P34481; -.
DR EnsemblMetazoa; F59B2.5a.1; F59B2.5a.1; WBGene00010309. [P34481-1]
DR EnsemblMetazoa; F59B2.5b.1; F59B2.5b.1; WBGene00010309. [P34481-2]
DR GeneID; 176273; -.
DR KEGG; cel:CELE_F59B2.5; -.
DR UCSC; F59B2.5; c. elegans. [P34481-1]
DR CTD; 176273; -.
DR WormBase; F59B2.5a; CE43506; WBGene00010309; rpn-6.2. [P34481-1]
DR WormBase; F59B2.5b; CE43486; WBGene00010309; rpn-6.2. [P34481-2]
DR eggNOG; KOG1463; Eukaryota.
DR GeneTree; ENSGT00530000063301; -.
DR HOGENOM; CLU_029573_2_1_1; -.
DR InParanoid; P34481; -.
DR OMA; KALKYMC; -.
DR OrthoDB; 1052430at2759; -.
DR PhylomeDB; P34481; -.
DR PRO; PR:P34481; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00010309; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IBA:GO_Central.
DR GO; GO:0005198; F:structural molecule activity; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR040773; Rpn6_N.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF01399; PCI; 1.
DR Pfam; PF18055; RPN6_N; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Proteasome; Reference proteome.
FT CHAIN 1..416
FT /note="Probable 26S proteasome regulatory subunit rpn-6.2"
FT /id="PRO_0000065379"
FT DOMAIN 217..386
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT VAR_SEQ 1..203
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_039826"
SQ SEQUENCE 416 AA; 46784 MW; 49A3A44D80F0217C CRC64;
MSATPVTLKA VQSEVSAQTA KSSEAEVKRC EDLILSYSRQ LAKEKDITGI RTLVESIRSF
YDLVGKARAS KLIRDIVEHA LTIDQGVGPA LDHGKKEKID LLTNCIGWAT SNKREFLRRS
LQARLIRLYN DIRDFTNAQK LAQDLSKELK KLEDRELLIE VSVEESKSSF NLNNLAKAKT
ALLTAKTNTN SAFASPQLQA SVDMQSGVLY SAEERDYKTS FSYFYEAFEG FASIGDKINA
TSALKYMILC KIMLNETEQL AGLLAAKEIV AYQKSPRIIA IRSMADAFRK RSLKDFVKAL
AEHKIELVED KVVAVHSQNL ERNMLEKEIS RVIEPYSEIE LSYIARVIGM TVPPVERAIA
RMILDKKLMG SIDQHGDTVV VYPKADAANQ FTRSLKTIRE LTKTVDVSYS RTKHFK
