PS1_ARATH
ID PS1_ARATH Reviewed; 1477 AA.
AC B7SY83; Q9C8N3;
DT 29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=FHA domain-containing protein PS1 {ECO:0000305};
DE AltName: Full=Protein PARALLEL SPINDLE 1 {ECO:0000303|PubMed:19043546};
DE Short=AtPS1 {ECO:0000303|PubMed:19043546};
GN Name=PS1 {ECO:0000303|PubMed:19043546};
GN OrderedLocusNames=At1g34355 {ECO:0000312|Araport:AT1G34355};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=19043546; DOI=10.1371/journal.pgen.1000274;
RA d'Erfurth I., Jolivet S., Froger N., Catrice O., Novatchkova M., Simon M.,
RA Jenczewski E., Mercier R.;
RT "Mutations in AtPS1 (Arabidopsis thaliana parallel spindle 1) lead to the
RT production of diploid pollen grains.";
RL PLoS Genet. 4:E1000274-E1000274(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Required for normal spindle orientation at male meiosis II
CC and normal formation of tetrad of microspores. Not involved in female
CC meiosis. {ECO:0000269|PubMed:19043546}.
CC -!- DISRUPTION PHENOTYPE: Diploid pollen grains (dyads of spores instead of
CC tetrads) due to defective meiosis II. Abnormal spindle orientation at
CC meiosis II. {ECO:0000269|PubMed:19043546}.
CC -!- MISCELLANEOUS: Diploid male spores in sp1 mutants give rise to viable
CC diploid pollen grains and spontaneous triploid plants in the next
CC generation. {ECO:0000269|PubMed:19043546}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG51901.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; EU839993; ACJ23185.1; -; mRNA.
DR EMBL; AC023913; AAG51901.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE31701.1; -; Genomic_DNA.
DR PIR; G86467; G86467.
DR RefSeq; NP_564445.1; NM_103158.3.
DR AlphaFoldDB; B7SY83; -.
DR SMR; B7SY83; -.
DR STRING; 3702.AT1G34355.1; -.
DR iPTMnet; B7SY83; -.
DR PaxDb; B7SY83; -.
DR PRIDE; B7SY83; -.
DR ProteomicsDB; 226383; -.
DR EnsemblPlants; AT1G34355.1; AT1G34355.1; AT1G34355.
DR GeneID; 840337; -.
DR Gramene; AT1G34355.1; AT1G34355.1; AT1G34355.
DR KEGG; ath:AT1G34355; -.
DR Araport; AT1G34355; -.
DR TAIR; locus:505006169; AT1G34355.
DR eggNOG; KOG1881; Eukaryota.
DR HOGENOM; CLU_008034_0_0_1; -.
DR InParanoid; B7SY83; -.
DR OrthoDB; 266095at2759; -.
DR PRO; PR:B7SY83; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; B7SY83; baseline and differential.
DR Genevisible; B7SY83; AT.
DR GO; GO:0031965; C:nuclear membrane; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0009555; P:pollen development; IMP:TAIR.
DR CDD; cd00060; FHA; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR002716; PIN_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF13638; PIN_4; 1.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF49879; SSF49879; 1.
DR SUPFAM; SSF88723; SSF88723; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Meiosis; Reference proteome.
FT CHAIN 1..1477
FT /note="FHA domain-containing protein PS1"
FT /id="PRO_0000433007"
FT DOMAIN 64..115
FT /note="FHA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00086"
FT REGION 188..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 588..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 789..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 832..911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 942..979
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1004..1030
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1159..1225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..608
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..818
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..894
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1015..1030
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1159..1191
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1195..1225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1477 AA; 163229 MW; DE16790E1D60B46A CRC64;
MEVKEEKLME EKQRLPEKTI PVFTVLKNGA ILKNIFVVNS RDFSSPERNG STVSDDDGEV
EEILVVGRHP DCDILLTHPS ISRFHLEIRS ISSRQKLFVT DLSSVHGTWV RDLRIEPHGC
VEVEEGDTIR IGGSTRIYRL HWIPLSRAYD LDNPFVSPLD ASTVLEQEEE NRMLEAENLE
VAQHQSLENT TSGDEGVLHL DVTSEGTGSS VPSEDEDTYV TTREMSMPVA SPSVLTLVRD
SVETQKLQFN EDLQTSPKWD LDVIESVAEK LSGSFVRSTQ QSGGDVEGLG CSELFDAAEA
DECDVRGDGG LHLNVISEKM ESSVPNMIEA ENLEVAQHQS LANTALGDDE DLHLDVTSEG
TGSSVPSEDE DTYITTMEIS VPLASPNVLT LARDSIKTQK LQSTQDFQTP TMWDLDVVEA
AAEKPSSSCV LGKKLSGGYV EELGCFELFV AAEADKCDVR GDGSLHLNEI SERMESSMSN
KEDDPFLAAK ETSSLPLSTD FINPETLWLV EDVQASPEFC TSSVKANAEN PSSGCSPSTE
QIDGCFETSG CSAFDLAAEV ESLSLHQEVS EETEFVTKEV MGVSSEPLGK ADIRSHEENG
ESEDSRQVIE VSAEPVAKAD IQSHEENGET EGSRQVIEVS PKSFSEAEPT IEILTGEAQG
IIGSEFPSEL AVETESENLL HQKSIGETKN EIRSHEDYGE TEDYGETECS WPDIAVSPSS
VSPPEPTLEI LTDEARGLLG SEFLSEVTVE TEIENLLHQK SNVETKADIL IHEDYGETEV
SRQIITVSPN SFSKAEPTLE TEDSRQQARG LVGSDSEFQS EVAMKTECEN LLNQKRNGET
KVSSRQASPV SDCLSTPKDR LSSINTDDIQ SLCSSSQPPS ESEVNPATDQ DQESGIISET
EKPKTELLIG SGRSEKYYSL SEIEGEENTD IGRLSRCPIP SALAAKTSED TKLIEELSSS
DSGSQENQTP ETHAVRDDVL CDMDSSSTCN IWSRRGKAAS VLKIRTNKSQ GKQKQTGRQP
KDKLHRKQAL SDKSISLTIH HGAEILEPEI FTPDKENLTP SSHMLKRLQD IGDVKDSKSS
LKLSGKSCSS LVHSSIAVLA SEAFTEPEIF TPDKENLTPS SHMLKRLREF GDIKDTKGSS
SKATRKPFFD IRMEENVMVE QEPEDLHSLG SKSKLKHEPL APKKKAERAP FQPLLEKSSF
QSQSYTEASS TASARNNISR GIRSSSNLSD AKSKMKWTIV LDTSSLLDKE SRKPLQLLQG
LKGTHLVVPR TVLRELNEVK RSRSFLFRRR TEIASSALDW IEECKVNSKW WIQVQSPTEE
TKAIAPTPPV TPQSNGSSAF PFSLHWNNYA PEIDSPTSED QVLECALLYR NRNRDEKLVL
LSNDVTLKIK AMAEGVICET PHEFYESLVN PFSERFMWTE STARGRTWSH LDNDVLRERY
NDRACRRKST YNRGESGAAA KGLKLILLHN SHYGHTH
